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Cor pulmonale

Right-sided heart failure; Pulmonary heart disease

 

Cor pulmonale is a condition that causes the right side of the heart to fail. Long-term high blood pressure in the arteries of the lung and right ventricle of the heart can lead to cor pulmonale.

Causes

 

High blood pressure in the arteries of the lungs is called pulmonary hypertension . It is the most common cause of cor pulmonale.

In people who have pulmonary hypertension, changes in the small blood vessels inside the lungs can lead to increased blood pressure in the right side of the heart. This makes it harder for the heart to pump blood to the lungs. If this high pressure continues, it puts a strain on the right side of the heart. That strain can cause cor pulmonale.

Lung conditions that cause a low blood oxygen level in the blood over a long time can also lead to cor pulmonale. Some of these are:

  • Autoimmune diseases that damage the lungs, such as scleroderma
  • Chronic obstructive pulmonary disease (COPD)
  • Chronic blood clots in the lungs
  • Cystic fibrosis (CF)
  • Scarring of the lung tissue ( interstitial lung disease )
  • Severe curving of the upper part of the spine ( kyphoscoliosis )
  • Obstructive sleep apnea , which causes stops in breathing because of airway inflammation
  • Idiopathic (no specific cause) tightening (constriction) of the blood vessels of the lungs

 

Symptoms

 

Shortness of breath or lightheadedness during activity is often the first symptom of cor pulmonale. You may also have a fast heartbeat and feel like your heart is pounding.

Over time, symptoms occur with lighter activity or even while you are at rest. Symptoms you may have are:

  • Fainting spells during activity
  • Chest discomfort, usually in the front of the chest
  • Chest pain
  • Swelling of the feet or ankles
  • Symptoms of lung disorders, such as wheezing or coughing
  • Bluish lips and fingers (cyanosis)

 

Exams and Tests

 

Your health care provider will perform a physical exam and ask about your symptoms. The exam may find:

  • Fluid buildup in your belly
  • Abnormal heart sounds
  • Bluish skin
  • Liver swelling
  • Swelling of the neck veins, which is a sign of high pressure in the right side of the heart
  • Ankle swelling

These tests may help diagnose cor pulmonale:

  • Blood antibody tests
  • Blood test to check for a substance called brain natriuretic peptide ( BNP )
  • Chest x-ray
  • CT scan of the chest , with or without an injection of a contrast fluid (dye)
  • Echocardiogram
  • ECG
  • Lung biopsy (rarely done)
  • Measurement of blood oxygen by checking arterial blood gas ( ABG )
  • Pulmonary (lung) function tests
  • Right heart catheterization
  • Ventilation and perfusion scan of the lungs (V/Q scan)
  • Tests for autoimmune lung disease

 

Treatment

 

The goal of treatment is to control symptoms. It is important to treat medical problems that cause pulmonary hypertension, because they can lead to cor pulmonale.

Many treatment options are available. In general, the cause of your cor pulmonale will determine which treatment you receive.

If your provider prescribes medicines, you may take them by mouth (oral), receive them through a vein (intravenous or IV), or breathe them in (inhaled). You will be closely monitored during treatment to watch for side effects and to see how well the medicine works for you. Never stop taking your medicines without first talking to your doctor.

Other treatments may include:

  • Blood thinners to reduce the risk of blood clots
  • Medicines to manage heart failure symptoms
  • Oxygen therapy at home
  • A lung or heart-lung transplant, if medicine does not work

Important tips to follow:

  • Avoid strenuous activities and heavy lifting.
  • Avoid traveling to high altitudes.
  • Get a yearly flu vaccine, as well as other vaccines, such as the pneumonia vaccine.
  • If you smoke, stop.
  • Use oxygen if your doctor prescribes it.
  • Women should not get pregnant.

 

Outlook (Prognosis)

 

How well you do depends on the cause of your cor pulmonale.

As your illness gets worse, you will need to make changes to your home so that you can manage as well as possible. You will also need help around your house.

 

Possible Complications

 

Cor pulmonale may lead to:

  • Life-threatening shortness of breath
  • Severe fluid buildup in your body
  • Shock
  • Death

 

When to Contact a Medical Professional

 

Call your provider if you have shortness of breath or chest pain.

 

Prevention

 

Do not smoke. Smoking causes lung disease, which can lead to cor pulmonale.

 

 

References

Ferri FF. Cor pulmonale. In: Ferri FF, ed. Ferri's Clinical Advisor 2016. Philadelphia, PA: Elsevier Mosby; 2016:368-370.

McLaughlin VV, Humbert M. Pulmonary hypertension. In: Mann DL, Zipes DP, Libby P, Bonow RO, Braunwald E, eds. Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine. 10th ed. Philadelphia, PA: Elsevier Saunders; 2015:chap 74.

 
  • Sarcoid, stage IV - chest X-ray - illustration

    This film shows advanced sarcoid, scarring of the lungs (the light streaking), and cavity formation (the dark areas in the upper right side of the picture).

    Sarcoid, stage IV - chest X-ray

    illustration

  • Acute vs. chronic conditions - illustration

    Acute conditions are severe and sudden in onset. This could describe anything from a broken bone to an asthma attack. A chronic condition, by contrast is a long-developing syndrome, such as osteoporosis or asthma. Note that osteoporosis, a chronic condition, may cause a broken bone, an acute condition. An acute asthma attack occurs in the midst of the chronic disease of asthma. Acute conditions, such as a first asthma attack, may lead to a chronic syndrome if untreated.

    Acute vs. chronic conditions

    illustration

  • Cor pulmonale - illustration

    Chronically low blood levels of oxygen may lead to pulmonary hypertension (high blood pressure in the lungs), and possibly to cor pulmonale. Cor pulmonale is also called right-sided heart failure, and is characterized by enlargement of the right ventricle. Treatment targets the underlying illness and may include supplemental oxygen, a low-salt diet or calcium channel blockers.

    Cor pulmonale

    illustration

  • Respiratory system - illustration

    Air is breathed in through the nasal passageways, travels through the trachea and bronchi to the lungs.

    Respiratory system

    illustration

    • Sarcoid, stage IV - chest X-ray - illustration

      This film shows advanced sarcoid, scarring of the lungs (the light streaking), and cavity formation (the dark areas in the upper right side of the picture).

      Sarcoid, stage IV - chest X-ray

      illustration

    • Acute vs. chronic conditions - illustration

      Acute conditions are severe and sudden in onset. This could describe anything from a broken bone to an asthma attack. A chronic condition, by contrast is a long-developing syndrome, such as osteoporosis or asthma. Note that osteoporosis, a chronic condition, may cause a broken bone, an acute condition. An acute asthma attack occurs in the midst of the chronic disease of asthma. Acute conditions, such as a first asthma attack, may lead to a chronic syndrome if untreated.

      Acute vs. chronic conditions

      illustration

    • Cor pulmonale - illustration

      Chronically low blood levels of oxygen may lead to pulmonary hypertension (high blood pressure in the lungs), and possibly to cor pulmonale. Cor pulmonale is also called right-sided heart failure, and is characterized by enlargement of the right ventricle. Treatment targets the underlying illness and may include supplemental oxygen, a low-salt diet or calcium channel blockers.

      Cor pulmonale

      illustration

    • Respiratory system - illustration

      Air is breathed in through the nasal passageways, travels through the trachea and bronchi to the lungs.

      Respiratory system

      illustration

    A Closer Look

     

      Self Care

       

      Tests for Cor pulmonale

       

         

        Review Date: 1/30/2016

        Reviewed By: Denis Hadjiliadis, MD, MHS, Associate Professor of Medicine, Pulmonary, Allergy, and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team.

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