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    Ectopic ADH secretion

    SIADH; Syndrome of inappropriate antidiuretic hormone secretion

    Ectopic ADH secretion is the release of Antidiuretic hormone (ADH), or vasopressin, from an abnormalplace inthe body. ADH is a substance produced naturally by the hypothalamus and released by the pituitary gland. This hormone controls the amount of water your body removes.

    Ectopic means "out of place."

    Causes

    The most common cause of ectopic ADH secretion is cancer. Certain lung cancers, as well as some head and neck tumors, are the most common cancers that cause this problem. In rare cases, many other tumors may cause ectopic ADH secretion.

    See also:

    • ADH test

    Symptoms

    The abnormal release of ADH makes it harder for the body to remove water. Fluid builds up in the body. Low blood sodium levels (hyponatremia) can occur.

    Often, there are no symptoms from low sodium levels. However, changes in mental status and even seizures may occur.

    Treatment

    Treatment is aimed at removing the cause of the problem (for example, surgery to remove a tumor producing ADH).

    Limiting fluid intake is another common treatment. This helps prevent excess water from building up in the body.

    Patients in the hospital with ectopic ADH that does not respond to other treatments may be given tolvaptan by mouth (orally) and conivaptan through a vein (intravenous). These treatments block the effects of ADH.

    References

    Stewart PM, Krone NP. The adrenal cortex. In: Kronenberg HM, Melmed S, Polonsky KS, Larsen PR, eds. Williams Textbook of Endocrinology. 12th ed. Philadelphia, Pa: Saunders Elsevier; 2011:chap 15.

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            Tests for Ectopic ADH secretion

              Review Date: 12/11/2011

              Reviewed By: Nancy J. Rennert, MD, Chief of Endocrinology & Diabetes, Norwalk Hospital, Associate Clinical Professor of Medicine, Yale University School of Medicine, New Haven, CT. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

              The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.
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              St. Luke's Hospital - 232 South Woods Mill Road - Chesterfield, MO 63017 Main Number: 314-434-1500 Emergency Dept: 314-205-6990 Patient Billing: 888-924-9200
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