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    Cystinuria

    Stones - cystine; Cystine stones

    Cystinuria is a rare condition in which stones made from an amino acid called cystine form in the kidney, ureter, and bladder. The condition is passed down through families.

    See also: Nephrolithiasis

    Causes

    To have the symptoms of cystinuria, you must inherit the faulty gene from both parents. Your children will also inherit a copy of the faulty gene from you.

    Cystinuria is caused by too much of an amino acid called cystine in the urine. After entering the kidneys, most cystine normally dissolves and goes back into the bloodstream. But people with cystinuria have a genetic defect that interferes with this process. As a result, cystine builds up in the urine and forms crystals or stones, which may get stuck in the kidneys, ureters, or bladder.

    About one in every 10,000 people have cystinuria. Cystine stones are most common in young adults under age 40. Less than 3% of urinary tract stones are cystine stones.

    Symptoms

    • Blood in the urine
    • Flank pain or pain in the side or back. Pain is usually on one side; it is rarely felt on both sides. Pain is often severe. It may get worse over days. You may also feel pain in the pelvis, groin, genitals, or between the upper abdomen and back.

    Exams and Tests

    The disorder is usually diagnosed after an episode of kidney stones. Testing the stones shows that they are made of cystine.

    Tests that may be done to detect stones and diagnose this condition include:

    • 24-hour urine collection
    • Abdominal CT scan, MRI, or ultrasound
    • Intravenous pyelogram (IVP)
    • Urinalysis

    Treatment

    The goal of treatment is to relieve symptoms and prevent more stones. A person with severe symptoms may need to be admitted to a hospital.

    Treatment involves drinking plenty of fluids, especially water, to produce large amounts of urine. You should drink at least 6 - 8 glasses per day.

    In some cases, fluids may need to be given through a vein (by IV).

    Medications may be prescribed to help dissolve the cystine crystals. Eating less salt can also decrease cystine release and stone formation.

    You may need pain relievers to control pain in the kidney or bladder area when you pass stones. Smaller stones usually pass through the urine on their own. Larger stones may need extra treatments. Some large stones may need to be removed with surgery:

    • Extracorporeal shock wave lithotripsy (ESWL) -- Sound waves are passed through the body and are focused on the stones to break them into small, passable fragments.ESWL may not work well forcystine stones because theyare very hard as compared withother types of stones.
    • Percutaneous nephrostolithotomy or nephrolithotomy-- A small tube is placed through the flank directly into the kidney. A telescope is then passed through the tube to fragment the stone under direct vision.
    • Ureteroscopy, for stones in the lower urinary tract.

    Outlook (Prognosis)

    Cystinuria is a chronic, lifelong condition. Stones commonly return. However, the condition rarely results in kidney failure, and it does not affect other organs.

    • Bladder injury from stone
    • Kidney injury from stone
    • Kidney infection
    • Ureteral obstruction
    • Urinary tract infection

    When to Contact a Medical Professional

    Call your health care provider if you have symptoms ofurinary tract stones.

    Prevention

    There are medications that can be taken so cystine does not form a stone. Ask your health care provider about these medications and their side effects. Any person with a known history of stones in the urinary tract should drink plenty of fluids to regularly produce a high amount of urine. This allows stones and crystals to leave the body before they become large enough to cause symptoms.

    References

    Elder JS. Urinary lithiasis. In: Kliegman RM, Stanton BF, St. Geme JW III, et al.,eds. Nelson Textbook of Pediatrics. 19th ed. Philadelphia, PA:Elsevier Saunders; 2011:chap 541.

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    • Female urinary tract

      illustration

    • Male urinary tract

      illustration

    • Cystinuria

      illustration

    • Nephrolithiasis

      illustration

      • Female urinary tract

        illustration

      • Male urinary tract

        illustration

      • Cystinuria

        illustration

      • Nephrolithiasis

        illustration

      Tests for Cystinuria

        Review Date: 10/2/2013

        Reviewed By: Scott Miller, MD, Urologist in private practice in Atlanta, Georgia. Also reviewed by David Zieve, MD, MHA, Bethanne Black, and the A.D.A.M. Editorial team.

        The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.
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