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    Polymyositis - adult

    Polymyositis is a rare inflammatory disease that leads to muscle weakness, swelling tenderness, and tissue damage. It is part of a larger group of diseases called myositis.

    Causes

    Polymyositis affects the skeletal muscles. It is also known as idiopathic inflammatory myopathy. The exact cause is unknown, but it may be related to an autoimmune reaction or infection.

    Polymyositis can affect people at any age. It most common in adults between ages 50 and 70, and in children ages 5 to 15. It affects women twice as often as men. It is more common in African Americans than Caucasians.

    Symptoms

    Polymyositis is a systemic disease, which means it affects the whole body. Muscle weakness and tenderness can be signs of polymyositis. A rash is a sign of a similar condition, dermatomyositis.

    Common symptoms include:

    • Difficulty swallowing
    • Muscle pain
    • Muscle weakness in the proximal muscles (shoulders, hips, etc.) this can make it hard to raise the arms over the head, get up from a sitting position, or climb stairs
    • Problems with the voice (caused by weak throat muscles)
    • Shortness of breath

    You may also have:

    • Fatigue
    • Fever
    • Joint pain
    • Loss of appetite
    • Morning stiffness
    • Weight loss

    Exams and Tests

    Tests may include:

    • Autoimmune antibodies and inflammation tests
    • CPK
    • Electromyography
    • MRI of affected muscles
    • Muscle biopsy
    • Myoglobin in the urine
    • Serum aldolase

    People with this condition also must be watched carefully for signs of cancer.

    Treatment

    The main treatment is with corticosteroid medicines. The dose of medicine is slowly tapered off as muscle strength improves. This takes about 4-6 weeks. You will stay on a low dose of a corticosteroid medicine after that. Medicines to suppress the immune system, such as methotrexate and azathioprine, may be used for people who do not respond to corticosteroids.

    Intravenous gamma globulin has been tried, with mixed results. Biologic drugs also may play in part in treating this condition but it is too soon to know.

    If the condition is associated with a tumor, it may improve if the tumor is removed.

    Outlook (Prognosis)

    Response to treatment varies based on the complications. The 5-year mortality rate can be as high as 1 in 5 patients.

    Many people, especially children, a period when no symptoms are present and recover. For most other people, immunosuppressant drugs can control the disease.

    In adults, death may result from:

    • Malnutrition
    • Pneumonia
    • Respiratory failure
    • Severe, long-term muscle weakness

    The major causes of death are cancer and lung disease.

    Possible Complications

    • Calcium deposits in the affected muscles, especially in children with the disease
    • Cancer
    • Heart disease, lung disease, or abdominal complications

    When to Contact a Medical Professional

    Call your health care provider if you have symptoms of this disorder. Seek emergency treatment if you have shortness of breath and difficulty swallowing.

    References

    Nagaraju K, Lundberg IE. Inflammatory Diseases of Muscle and Other Myopathies. In: Firestein GS, Budd RC, Gabriel SE, et al, eds. Kelley's Textbook of Rheumatology. 9th ed. Philadelphia, Pa: Saunders Elsevier;2012:chap 85.

    Miller FW, Polymyositis and Dermatomyositis. In: Goldman L, Schafer AI, eds. Cecil Medicine. 24th ed. Philadelphia, Pa: Saunders Elsevier; 2011:chap 277.

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              Review Date: 3/22/2013

              Reviewed By: Ariel D. Teitel, MD, MBA, Clinical Associate Professor of Medicine, NYU Langone Medical Center. Review provided by VeriMed Healthcare Network. Also reviewed by A.D.A.M. Health Solutions, Ebix, Inc., Editorial Team: David Zieve, MD, MHA, Bethanne Black, Stephanie Slon, and Nissi Wang.

              The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.
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