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    Factor XII (Hageman factor) deficiency

    Factor XII deficiency is an inherited disorder that affects a protein (factor XII) involved in blood clotting.

    Causes

    When you bleed, the body launches a series of reactions that help the blood clot. This is called the coagulation cascade. The process involves special proteins called coagulation factors. (Factor XII is a coagulation factor in this series of reactions.)

    Each factor has a reaction that triggers the next reaction. The final product of the coagulation cascade is the blood clot. When one or more of these clotting factors are missing, there is usually a higher chance of bleeding.

    A lack of factor XII does not cause the affected person to bleed abnormally, but the blood takes longer than normal to clot in a test tube.

    Factor XII deficiency is a rare inherited disorder.

    Symptoms

    There are usually no symptoms.

    Exams and Tests

    Factor XII deficiency is usually found when clotting tests are done for routine screening.

    Tests may include:

    • Factor XII assay
    • Partial thromboplastin time (PTT)

    Treatment

    Treatment is usually not needed.

    Outlook (Prognosis)

    The outcome is expected to be good without treatment.

    Possible Complications

    There are usually no complications.

    When to Contact a Medical Professional

    The health care provider usually discovers this condition after noticing prolonged clotting in the process of running other laboratory tests.

    Prevention

    This is an inherited disorder. There is no known way to prevent it.

    References

    Gailani D, Neff AT. Rare coagulation factor deficiencies. In: Hoffman R, Benz EJ Jr, Shattil SJ, et al, eds. Hoffman Hematology: Basic Principles and Practice. 5th ed. Philadelphia, Pa: Churchill Livingstone Elsevier;2008:chap 127.

    Kessler C. Hemorrhagic disorders: Coagulation factor deficiencies. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier;2007:chap 180.

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    • Blood clots

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      • Blood clots

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      A Closer Look

        Tests for Factor XII (Hageman factor) deficiency

        Review Date: 2/28/2011

        Reviewed By: David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine; and Yi-Bin Chen, MD, Leukemia/Bone Marrow Transplant Program, Massachusetts General Hospital. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

        The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.
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        St. Luke's Hospital - 232 South Woods Mill Road - Chesterfield, MO 63017 Main Number: 314-434-1500 Emergency Dept: 314-205-6990 Patient Billing: 888-924-9200
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