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    Factor V deficiency

    Parahemophilia; Owren's disease

    Factor V deficiency is a condition that is passed down through families whichaffects the ability of the blood to clot.

    Causes

    Blood clotting is a complex process involving as many as 20 different proteins in blood plasma. These proteins are calledblood coagulation factors.

    Factor V deficiency is caused by a lack of the Factor V. When certain blood clotting factors are low or missing, your blood does not clot properly.

    Factor V deficiency is rare. It may be caused by:

    • Adefective Factor V gene pass down through families (inherited)
    • Anantibody that interferes with normal Factor V function

    You can may get an antibody that interferes withFactor V:

    • After giving birth
    • After being treated with a certain type of fibrin glue
    • After surgery
    • With autoimmune diseases and certain cancers

    Sometimes the cause is unknown.

    The disease is similar to hemophilia, except bleeding into joints is less common. In the inherited form of Factor V deficiency, a family history of a bleeding disorder is a risk factor.

    Symptoms

    • Bleeding into the skin
    • Bleeding of the gums
    • Excessive bruising
    • Nosebleeds
    • Prolonged or excessive loss of blood with surgery or trauma
    • Umbilical stump bleeding

    Exams and Tests

    • Factor V assay
    • Blood clotting tests, includingpartial thromboplastin time (PTT) andprothrombin time
    • Bleeding time

    Treatment

    You will be givenfresh blood plasma or fresh frozen plasma infusions during a bleeding episode or after surgery. These treatments will correct the deficiency temporarily.

    Outlook (Prognosis)

    The outlook is good with diagnosis and proper treatment.

    Possible Complications

    Severe bleeding (hemorrhage) could occur.

    When to Contact a Medical Professional

    Go to the emergency room or call the local emergency number (such as 911) if you have an unexplained or prolonged loss of blood.

    References

    Ragni MV. Hemorrhagic disorders: coagulation factor deficiencies. In: Goldman L, Schafer AI, eds. Cecil Medicine. 24th ed. Philadelphia, Pa: Saunders Elsevier; 2011:chap 167.

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    • Blood clot formation

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    • Blood clots

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      • Blood clot formation

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      • Blood clots

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      A Closer Look

        Self Care

          Tests for Factor V deficiency

          Review Date: 2/16/2012

          Reviewed By: Todd Gersten, MD, Hematology/Oncology, Palm Beach Cancer Institute, West Palm Beach, FL. Review provided by VeriMed Healthcare Network. Also reviewed by Linda J. Vorvick, MD, Medical Director and Director of Didactic Curriculum, MEDEX Northwest Division of Physician Assistant Studies, Department of Family Medicine, UW Medicine, School of Medicine, University of Washington; David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

          The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.
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          St. Luke's Hospital - 232 South Woods Mill Road - Chesterfield, MO 63017 Main Number: 314-434-1500 Emergency Dept: 314-205-6990 Patient Billing: 888-924-9200
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