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    Hereditary ovalocytosis

    Ovalocytosis - hereditary

    Hereditary ovalocytosis is rare condition passed down through families (inherited) in which blood cells are slightly oval-shaped instead of round. It is a form of hereditary elliptocytosis.

    Causes

    Ovalocytosis is mainly found in Southeast Asian populations.

    Symptoms

    Newborn infants with ovalocytosis may have anemia and jaundice. Adults usually do not show symptoms and are known as asymptomatic.

    Exams and Tests

    An examination by your health care provider may occasionally show an enlarged spleen.

    This condition is diagnosed by looking at the shape of blood cells under a microscope. The following tests may also be done:

    • Complete blood count (CBC) to check for anemia or red blood cell destruction
    • Blood smear to determine cell shape
    • Bilirubin level (may be high)
    • Lactate dehydrogenase level (may be high)
    • Ultrasound of the abdomen (may show gallstones)

    Treatment

    In severe cases, the disease may be treated by removal of the spleen (splenectomy).

    Possible Complications

    The condition may be associated with gallstones or kidney problems.

    References

    Golan DE. Hemolytic anemias: red cell membrane and metabolic defects. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 165.

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    • Ovalocytoses

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    • Blood cells

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      • Ovalocytoses

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      • Blood cells

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      Tests for Hereditary ovalocytosis

        Review Date: 2/5/2010

        Reviewed By: David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine; Yi-Bin Chen, MD, Leukemia/Bone Marrow Transplant Program, Massachusetts General Hospital. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

        The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.
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