Hemoglobin C disease
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Hemoglobin C disease

Definition

Hemoglobin C disease is a blood disorder passed down through families. It leads to a type of anemia, which occurs when red blood cells break down earlier than normal.

Alternative Names

Clinical hemoglobin C

Causes

Hemoglobin C is an abnormal type of hemoglobin, the protein in red blood cells that carries oxygen. It is a type of hemoglobinopathy. The disease is caused by problem with a gene called beta globin.

The disease most often occurs in African Americans. You are more likely to have hemoglobin C disease if someone in your family has had it.

Symptoms

Most people do not have symptoms. Occasionally, jaundice may occur. Some persons with this disease may develop gallstones that require treatment.

Exams and Tests

Physical examination may show an enlarged spleen.

Tests that may be done include:

Treatment

Usually no treatment is needed. Folic acid supplementation may help your body produce normal red blood cells and improve the symptoms of the anemia.

Outlook (Prognosis)

People with hemoglobin C disease can expect to lead a normal life.

Possible Complications

Complications include anemia, gall bladder disease, and enlargement of the spleen.

When to Contact a Medical Professional

Call your health care provider if you have symptoms of hemoglobin C disease.

Prevention

Genetic counseling may be appropriate for high-risk couples who wish to have a baby.

References

Steinberg MH. Sickle cell disease and associated hemoglobinopathies. In: Goldman L, Schafer AI, eds. Cecil Medicine. 24th ed. Philadelphia, Pa: Saunders Elsevier; 2011:chap 166.


Review Date: 2/8/2012
Reviewed By: Todd Gersten, MD, Hematology/Oncology, Palm Beach Cancer Institute, West Palm Beach, FL. Review provided by VeriMed Healthcare Network; Linda J. Vorvick, MD, Medical Director and Director of Didactic Curriculum, MEDEX Northwest Division of Physician Assistant Studies, Department of Family Medicine, UW Medicine, School of Medicine, University of Washington. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.
The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.
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