Lamellar ichthyosis
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Lamellar ichthyosis

Definition

Lamellar ichthyosis is a rare skin condition. It appears at birth and continues throughout life.

Causes

Lamellar ichthyosis is passed down through families (inherited). Both parents must have at least one abnormal gene to pass the condition to their children.

Symptoms

A baby with this condition is born with a shiny, waxy layer of skin called a collodian membrane. The membrane sheds within the first 2 weeks of life. The underneath is red as scaly skin remains underneath. It resembles the surface of a fish.

Treatment

Moisturizers containing medicines such as urea, ammonium lactate, or other alpha-hydroxy acids may help shed dead skin layers. Also, retinoid medications such as tazarotene may be applied to the skin.

Possible Complications

Babies are at risk for infection when the collodian membrane is shed.

Eye problems may occur later in life because the eyes cannot close completely.

References

Morelli JG. Disorders of keratinization. In: Kliegman RM, Behrman RE, Jenson HB, Stanton BF, eds. Nelson Textbook of Pediatrics. 18th ed. Philadelphia, Pa: Saunders Elsevier;2007:chap 657.


Richard G, Rigpfeil F.  Ichthyoses, Erythrokeratodermas and Related Disorders. In: Bolognia JL, Jorizzo JL, Schaffer JV, et al, eds.Dermatology. 3rd ed. Philadelphia, Pa: Mosby Elsevier; 2012:chap 57.



 


Review Date: 11/20/2012
Reviewed By: Kevin Berman, MD, PhD, Atlanta Center for Dermatologic Disease, Atlanta, GA. Review provided by VeriMed Healthcare Network. Also reviewed by A.D.A.M. Health Solutions, Ebix, Inc., Editorial Team: David Zieve, MD, MHA, David R. Eltz, Stephanie Slon, and Nissi Wang.
The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.
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