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    Acanthosis nigricans

    Acanthosis nigricans is a skin disorder in which there is darker, thick, velvety skin in body folds and creases.

    Causes

    Acanthosis nigricans can affect otherwise healthy people, or it can be related to medical problems. Some cases are genetically inherited. The condition is most commonly seen among people of African descent, in part because it is easier to see in darker skin.

    Obesity can lead to acanthosis nigricans, as can some endocrine disorders. It is often found in people with obesity-related insulin resistance.

    Some medicines, particularly hormones such as human growth hormone orbirth control pills,can also cause acanthosis nigricans.

    People with lymphoma or cancers of the gastrointestinal or genitourinary tracts can also develop severe cases of acanthosis nigricans.

    Symptoms

    Acanthosis nigricans usually appears slowly and doesn't cause any symptoms other than skin changes.

    Eventually, dark, velvety skin with very visible markings and creases appears in the armpits, groin and neck folds, and over the joints of the fingers and toes.

    Less commonly, the lips, palms, soles of the feet, or other areas may be affected. These symptoms are more common in people with cancer.

    Exams and Tests

    Your health care provider can usually diagnose acanthosis nigricans by looking at your skin. A skin biopsy may be needed in unusual cases.

    If there is no clear cause of acanthosis nigricans, your doctor may order tests. This may include:

    • Blood tests to check blood sugar level
    • Endoscopy
    • X-rays

    Treatment

    Because acanthosis nigricans usually only changes the skin's appearance, no treatment is needed.

    It is important, however, to treat any underlying medical problem that may be causing these skin changes. When acanthosis nigricans is related to obesity, losing weight often improves the condition.

    Outlook (Prognosis)

    Acanthosis nigricans often fades if the cause can be found and treated.

    When to Contact a Medical Professional

    Call your health care provider if you develop areas of thick, dark, velvety skin.

    References

    Habif TP. Cutaneous manifestations of internal disease. In: Habif TP, ed. Clinical Dermatology. 5th ed. Philadelphia, Pa: Mosby Elsevier;2009:chap 26.

    Morelli JG. Diseases of the epidermis. In: Kliegman RM, Behrman RE, Jenson HB, Stanton BF, eds. Nelson Textbook of Pediatrics. 18th ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap. 656.

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      Review Date: 7/11/2012

      Reviewed By: Kevin Berman, MD, PhD, Atlanta Center for Dermatologic Disease, Atlanta, GA. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

      The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.
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