Fibrous dysplasia
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Fibrous dysplasia

Definition

Fibrous dysplasia is a bone disease that destroys and replaces normal bone with fibrous bone tissue. One or more bones can be affected.

Alternative Names

Inflammatory fibrous hyperplasia; Idiopathic fibrous hyperplasia

Causes

Fibrous dysplasia occurs in childhood, usually between ages 3 - 15. The condition does not run in families (not hereditary), and the cause is unknown.

Symptoms

  • Bone pain
  • Bone sores (lesions)
  • Difficulty walking
  • Endocrine gland problems
  • Fractures or bone deformities (rare)
  • Unusual skin color (pigmentation)

The bone lesions may stop when the child reaches puberty.

Exams and Tests

The doctor will perform a physical examination. X-rays of bones are taken.

Treatment

There is no cure for fibrous dysplasia. Bone fractures or deformities are treated as appropriate. The patient is screened for endocrine disorders as needed.

Outlook (Prognosis)

The outlook depends on the severity of the condition and the symptoms that occur.

Possible Complications

  • Cushing's disease
  • Gigantism or acromegaly
  • Heart rhythm disturbance
  • Hyperthyroidism
  • Rickets

When to Contact a Medical Professional

Call your health care provider if your child has symptoms of this condition, such as repeated bone fractures and unexplained bone deformity.

Specialists in orthopedics, endocrinology, and genetics may be involved in your child's diagnosis and care.

Prevention

There is no known way to prevent fibrous dysplasia. Treatment aims to prevent complications, such as recurrent bone fractures, to help make the condition less severe.

References

Heck RS Jr. Benign bone tumors and nonneoplastic conditions simulating bone tumors. In: Canale ST, Beaty JH, eds. Campbell's Operative Orthopaedics. 11th ed. Philadelphia, Pa: Mosby Elsevier; 2007:chap 20.

Arndt CAS. Benign tumors and tumor-like processes of bone. In: Kliegman RM, Behrman RE, Jenson HB, Stanton BF, eds. Nelson Textbook of Pediatrics. 19th ed. Philadelphia, Pa: Saunders Elsevier; 2011:chap 495.2.


Review Date: 11/13/2011
Reviewed By: Neil K. Kaneshiro, MD, MHA, Clinical Assistant Professor of Pediatrics, University of Washington School of Medicine. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.
The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.
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St. Luke's Hospital - 232 South Woods Mill Road - Chesterfield, MO 63017 Main Number: 314-434-1500 Emergency Dept: 314-205-6990 Patient Billing: 888-924-9200
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