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    Takayasu arteritis

    Pulseless disease

    Takayasu arteritis is an inflammation of the aorta -- the artery that carries blood from the heart to the rest of the body -- and its major branches.

    See also: Aortic arch syndrome

    Causes

    The cause of Takayasu arteritis is unknown. The disease occurs mainly in children and women younger than 30, especially those who are of Asian or African descent.

    It appears to be an autoimmune condition, where immune cells are wrongly targeted against the body's own tissues, and it may involve other systems.

    Symptoms

    • Arm weakness or pain with use
    • Chest pain
    • Dizziness
    • Fatigue
    • Fever
    • Lightheadedness
    • Muscle or joint pain
    • Skin rash
    • Night sweats
    • Vision changes
    • Weight loss

    Exams and Tests

    • Decreased radial pulses (at the wrist)
    • Difference in blood pressure between the two arms
    • High blood pressure (hypertension)

    There may also be signs of inflammation (pericarditis or pleuritis).

    Tests:

    • Arteriogram
    • Angiogram
    • Complete blood count (CBC)
    • C-reactive protein (CRP)
    • Electrocardiogram (ECG)
    • Erythrocyte sedimentation rate (ESR)
    • Magnetic resonance angiography (MRA)
    • Magnetic resonance imaging (MRI)
    • Ultrasound
    • X-ray of the chest

    Treatment

    Treatment of Takayasu arteritis is difficult, but patients who do have the right treatment can see positive results. Early detection is important.

    Most patients are treated with steroids and immunosuppressive drugs. Surgery is reserved for complications caused by narrowed arteries.

    Surgery to bypass narrowed arteries -- angioplasty or stent placement -- may be needed to supply blood or open up the constriction.

    Outlook (Prognosis)

    This disease can be fatal. However, with a combination of aggressive medical and surgical treatment, death rates have dropped dramatically.

    In well managed cases of Takayasu arteritis, the long-term survival rate is greater than 90%. The survival rate is better for adults than for children.

    Possible Complications

    • Blood clot
    • Heart attack
    • Heart failure
    • Pericarditis
    • Pleuritis
    • Stroke

    When to Contact a Medical Professional

    Call your health care provider if you have symptoms of this condition. Weak pulse, chest pain, and breathing difficulty require immediate care.

    References

    Maksimowicz-McKinnon K, Hoffman GS. Takayasu arteritis: what is the long-term prognosis? Rheum Dis Clin North Am. 2007;33:777-786.

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        Tests for Takayasu arteritis

          Review Date: 2/2/2012

          Reviewed By: Ariel D. Teitel, MD, MBA, Clinical Associate Professor of Medicine, NYU Langone Medical Center. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

          The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.
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