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    Reye syndrome

    Reye syndrome is sudden (acute) brain damage and liver function problems of unknown cause.

    The syndrome has occurred in children who have been givenaspirin when they have chicken pox or the flu. Reye syndrome has become very uncommon since aspirin is no longer recommended for routine use in children.


    Reye syndrome is most often seen inchildren ages 4 - 12. Most cases that occur with chickenpox are in children ages 5 - 9. Cases that occur with the flu are usually in children ages 10 - 14.


    Children with Reye syndrome get sick very suddenly. The syndrome often begins with vomiting, which lasts for many hours. The vomiting is quickly followed by irritable and aggressive behavior. As the condition gets worse, the child may be unable to stay awake and alert.

    Other symptoms of Reye syndrome:

    • Confusion
    • Lethargy
    • Loss of consciousness or coma
    • Mental changes
    • Nausea and vomiting
    • Seizures
    • Unusual placement of arms and legs (decerebrate posture) -- the arms are extended straight and turned toward the body, the legs are held straight, and the toes are pointed downward

    Other symptoms that can occur with this disorder include:

    • Double vision
    • Hearing loss
    • Muscle function loss or paralysis of the arms or legs
    • Speech difficulties
    • Weakness in the arms or legs

    Exams and Tests

    The following tests may be used to diagnose Reye syndrome:

    • Blood chemistry tests
    • Head CT or head MRI scan
    • Liver biopsy
    • Liver function tests
    • Serum ammonia test
    • Spinal tap


    There is no specific treatment for this condition. The health care provider will monitor the pressure in the brain, blood gases, and blood acid-base balance (pH).

    Treatments may include:

    • Breathing support (a breathing machine may be needed during a deep coma)
    • Fluids by IV to provide electrolytes and glucose
    • Steroids to reduce swelling in the brain

    Outlook (Prognosis)

    How well a person does depends on the severity of any coma, as well as other factors.

    The outcome for those who survive an acute episode may be good.

    Possible Complications

    • Coma
    • Permanent brain damage
    • Seizures

    Untreated, seizures and coma may be life-threatening.

    When to Contact a Medical Professional

    Go to the emergency room or call the local emergency number (such as 911) immediately if your child has confusion, lethargy, or other mental changes.


    Never give a child aspirin unless told to do so by your doctor.

    When a child must take aspirin, take care to reduce the child's risk of catching a viral illness such as the flu and chickenpox. Avoid aspirin for several weeks after the child has received a varicella (chickenpox) vaccine.

    Note: Other over-the-counter medications, such as Pepto-Bismol and substances with oil of wintergreen also contain aspirin compounds called salicylates. Do not give these to a child who has a cold or fever.


    Cohen J, Powderly WG. Infectious Diseases. 2nd ed. New York, NY: Elsevier; 2004:310-311.

    Goetz CG. Textbook of Clinical Neurology. 2nd ed. St. Louis, Mo: WB Saunders; 2003:656-657.

    Ferri FF. Reye’s syndrome. In: Ferri FF, ed. Ferri’s Clinical Advisor 2011. 1st ed. Philadelphia, Pa: Mosby Elsevier; 2010:section 1.

    Noble J. Textbook of Primary Care Medicine. 3rd ed. St. Louis, Mo: Mosby; 2001:46-47.

    Michaels MG. Reye syndrome. In: Long SS, Pickering LK, Prober CG, eds. Principles and Practice of Pediatric Infectious Diseases. 2nd ed. Philadelphia, Pa: Churchill Livingstone; 2003:chap 50.

    Johnston MV. Encephalopathies. In: Kliegman RM, Behrman RE,Jenson HB, Stanton BF, eds. Nelson Textbook of Pediatrics. 19th ed. Philadelphia ,Pa: Saunders Elsevier; 2011:chap 591.


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          Tests for Reye syndrome

            Review Date: 8/1/2012

            Reviewed By: Neil K. Kaneshiro, MD, MHA, Clinical Assistant Professor of Pediatrics, University of Washington School of Medicine. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M. Health Solutions, Ebix, Inc.

            The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.

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