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    Transposition of the great vessels

    Transposition of the great arteries; TGA; d-TGA

    Transposition of the great vessels is a heart defect that occurs from birth (congenital).The two major vessels that carry blood away from the heart -- the aorta and the pulmonary artery -- are switched (transposed).

    Causes

    The cause of most congenital heart defects is unknown.

    Factors in the mother that may increase the risk of this condition include:

    • Age over 40
    • Alcoholism
    • Diabetes
    • Poor nutrition during pregnancy (prenatal nutrition)
    • Rubella or other viral illness during pregnancy

    Transposition of the great vessels is a cyanotic heart defect. This means there is decreased oxygen in the blood that is pumped from the heart to the rest of the body.

    In normal hearts, blood that returns from the body goes through the right side of the heart and pulmonary artery to the lungs to get oxygen. The blood then comes back to the left side of the heart and travels out the aorta to the body.

    In transposition of the great vessels, the blood goes to the lungs, picks up oxygen, returns to the heart, and then flows right back to the lungs without ever going to the body. Blood from the body returns to the heart and goes back to the body without ever picking up oxygen in the lungs.

    Symptoms appear at birth or very soon afterward. How bad the symptoms are depends on the type and size of heart defects (such as atrial septal defect or patent ductus arteriosus) and how much oxygen moves through the body's general blood flow.

    The condition is the second most common cyanotic heart defect.

    Symptoms

    • Blueness of the skin
    • Clubbing of the fingers or toes
    • Poor feeding
    • Shortness of breath

    Exams and Tests

    The health care provider may detect a heart murmur while listening to the chest with a stethoscope. The baby's mouth and skin will be a blue color.

    Tests often include the following:

    • Cardiac catheterization
    • Chest x-ray
    • ECG
    • Echocardiogram (if done before birth, it is called a fetal echocardiogram)
    • Pulse oximetry (to check blood oxygen level)

    Treatment

    The baby will immediately receive a medicine called prostaglandin through an IV (intravenous line). This medicine helps keep a blood vessel called the the ductus arteriosus open, allowing some mixing of the two blood circulations.

    A procedure using a long, thin flexible tube (balloon atrial septostomy) may be needed to create a large hole in the atrial septum to allow blood to mix.

    A surgery called an arterial switch procedure is used to permanently correct the problem within the baby's first week of life. This surgery switches the great arteries back to the normal position and keeps the coronary arteries attached to the aorta.

    Outlook (Prognosis)

    The child's symptoms will improve after surgery to correct the defect. Most infants who undergo arterial switch do not have symptoms after surgery and live normal lives. If corrective surgery is not performed, the life expectancy is only months.

    Possible Complications

    • Coronary artery problems
    • Heart valve problems
    • Irregular heart rhythms (arrhythmias)

    When to Contact a Medical Professional

    This condition can be diagnosed before birth using a fetal echocardiogram. If not, it is usually diagnosed soon after a baby is born.

    Go to the emergency room or call the local emergency number (such as 911) if your baby's skin develops a bluish color, especially in the face or trunk.

    Call your health care provider if your baby has this condition and new symptoms develop, get worse, or continue after treatment.

    Prevention

    Women who plan to become pregnant should be immunized against rubella if they are not already immune. Eating well, avoiding alcohol, and controlling diabetes both before and during pregnancy may be helpful.

    References

    Webb GD, Smallhorn JF, Therrien J, Redington AN. Congenital heart disease. In: Bonow RO, Mann DL, Zipes DP, Libby P, Libby P, eds. Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine, 9th ed. Philadelphia, Pa:Saunders Elsevier; 2011:chap 65.

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      A Closer Look

        Self Care

          Tests for Transposition of the great vessels

            Review Date: 12/28/2011

            Reviewed By: Kurt R. Schumacher, MD, Pediatric Cardiology, University of Michigan Congenital Heart Center, Ann Arbor, MI. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

            The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.
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