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    Niacin

    Nicotinic acid; Vitamin B3

    Niacin is a type of B vitamin. It is water-soluble, which means it is not stored in the body. Water-soluble vitamins dissolve in water. Leftover amounts of the vitamin leave the body through the urine. That means you need a continuous supply of such vitamins in your diet.

    Function

    Niacin helps the digestive system, skin, and nerves to function. It is also important for converting food to energy.

    Food Sources

    Niacin (also known as vitamin B3) is found in:

    • Dairy products
    • Eggs
    • Enriched breads and cereals
    • Fish
    • Lean meats
    • Legumes
    • Nuts
    • Poultry

    Niacin and Cardiovascular Disease

    For many years, doses of 1 - 3 grams of nicotinic acid per day has been a treatment option for low HDL cholesterol and high LDL cholesterol and triglyceride levels.

    Side Effects

    A deficiency of niacin causes pellagra. The symptoms include:

    • Digestive problems
    • Inflamed skin
    • Mental impairment

    Large doses of niacin can cause:

    • Increased blood sugar (glucose) level)
    • Liver damage
    • Peptic ulcers
    • Skin rashes

    Even normal doses can be associated with feeling warmth, redness, itching or tingling of the face, neck, arms or upper chest. This is called “flushing” and it usually improves after taking niacin on a regular basis for awhile. To prevent flushing, do not drink hot beverages or alcohol at the same time you take niacin. New forms of nicotinic acid reduce this side effect. Nicotinamide does not cause these side effects.

    Recommendations

    Reference Intakes

    Recommendations for niacin and other nutrients are provided in the Dietary Reference Intakes (DRIs), which are developed by the Food and Nutrition Board at the Institute of Medicine. DRI is the term for a set of reference values that are used to plan and assess the nutrient intakes of healthy people. These values, which vary by age and gender, include:

    • Recommended Dietary Allowance (RDA): average daily level of intake that is enough to meet the nutrient requirements of nearly all (97 - 98%) healthy people.
    • Adequate Intake (AI): when there is not enough evidence to develop an RDA, the AI is set at a level that is thought to ensure enough nutrition.

    Dietary Reference Intakes for Niacin:

    Infants

    • 0 - 6 months: 2* milligrams per day (mg/day)
    • 7 - 12 months: 4* mg/day

    *Adequate Intake (AI)

    Children

    • 1 - 3 years: 6 mg/day
    • 4 - 8 years: 8 mg/day
    • 9 - 13 years: 12 mg/day

    Adolescents and Adults

    • Males age 14 and older: 16 mg/day
    • Females age 14 and older: 14 mg/day

    Specific recommendations depend on age, gender, and other factors (such as pregnancy). Women who are pregnant or breast-feeding need higher amounts. Ask your health care provider which amount is best for you.

    The best way to get the daily requirement of essential vitamins is to eat a balanced diet that contains a variety of foods.

    References

    Escott-Stump S, ed. Nutrition and Diagnosis-Related Care. 6th ed. Philadelphia, Pa: Lippincott Williams & Wilkins; 2008.

    Sarubin Fragaakis A, Thomson C. The Health Professional's Guide to Popular Dietary Supplements. 3rd ed. Chicago, Il: American Dietetic Association; 2007.

    Institute of Medicine. Food and Nutrition Board. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, PantothenicAcid, Biotin, and Choline. National Academy Press, Washington, DC, 1998.

    Cervantes-Laurean D, McElvaney NG, Moss J. Niacin. In: Shils ME, Olson JA, Shike M, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, Md. Williams & Wilkins; 1999:401-411.

    AIM-HIGH Investigators. The role of niacin in raising high-density lipoprotein cholesterol to reduce cardiovascular events in patients with atherosclerotic cardiovascular disease and optimally treated low-density lipoprotein cholesterol Rationale and study design. The Atherothrombosis Intervention in Metabolic syndrome with low HDL/high triglycerides: Impact on Global Health outcomes (AIM-HIGH). Am Heart J. 2011 Mar;161(3):471-477.e2.

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    • Vitamin B3 benefit

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    • Vitamin B3 deficit

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    • Vitamin B3 source

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      • Vitamin B3 benefit

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      • Vitamin B3 deficit

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      • Vitamin B3 source

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      A Closer Look

      Review Date: 2/18/2013

      Reviewed By: Alison Evert, MS, RD, CDE, Nutritionist, University of Washington Medical Center Diabetes Care Center, Seattle, Washington. Also reviewed by A.D.A.M. Health Solutions, Ebix, Inc., Editorial Team: David Zieve, MD, MHA, David R. Eltz, Stephanie Slon, and Nissi Wang.

      The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.
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