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    Bence-Jones protein - quantitative

    Immunoglobulin light chains - urine; Urine Bence-Jones protein

    A quantitative Bence-Jones protein test measures the specific level of abnormal proteins (Bence-Jones proteins) in your urine.

    How the Test is Performed

    A clean-catch (midstream) urine sample is needed.

    Men or boys should first wipe clean the head of the penis. Women or girls need to wash the area between the lips of the vagina with soapy water and rinse well.

    As you start to urinate, allow a small amount to fall into the toilet bowl (this clears the urethra of contaminants). Then, in a clean container, catch about 1 to 2 ounces of urine and remove the container from the urine stream. Give the container to the health care provider or assistant.

    In infants, thoroughly wash the area around the urethra. Open a urine collection bag (a plastic bag with an adhesive paper on one end), and place it on your infant. For boys, the entire penis can be placed in the bag and the adhesive attached to the skin. For girls, the bag is placed over the labia. Place a diaper over the infant (bag and all).

    Check your baby frequently and remove the bag after the infant has urinated into it. For active infants, this procedure may take a couple of attempts -- lively infants can displace the bag. The urine is drained into a container for transport back to the health care provider.

    How the Test Will Feel

    The test involves only normal urination, and there is no discomfort.

    Why the Test is Performed

    Bence-Jones proteins are a part of regular antibodies, called light chains.Sometimes, when your body makes too many antibodies, the level of light chains also rises. These proteins arerelatively small and filtered out by the kidneys. They spill over into the urine.

    Your doctor may order this test:

    • To diagnosehealth conditions that lead to protein in the urine
    • If youhave a lot of protein in your urine
    • If you have signs of multiple myeloma

    Normal Results

    A normal result means no Bence-Jones proteins are found in your urine.

    What Abnormal Results Mean

    Bence-Jones proteins are rarely found in urine. If they are, it is usually associated with multiple myeloma.

    An abnormal result may also be due to:

    • Amyloidosis
    • Chronic lymphocytic leukemia
    • Lymphoma
    • Monoclonal gammopathy of unknown significance (MGUS)
    • Waldenstrom's macroglobulinemia

    Considerations

    Urine immunofixation is a better test for detecting Bence-Jones proteins.

    References

    McPherson RA, Massey HD. Laboratory evaluation of immunoglobulin function and humoral immunity. In McPherson RA, Pincus MR, eds. Henry's Clinical Diagnosis and Management by Laboratory Methods. 22nd ed. Philadelphia,Pa: Saunders Elsevier; 2011:chap 46.

    Perry MC. Plasma cell disorders. In Goldman L, Schafer AI,eds. Cecil Medicine. 24th ed. Philadelphia, PA: Saunders Elsevier; 2011: chap193.

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    • Male urinary system

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      • Male urinary system

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          Tests for Bence-Jones protein - quantitative

          Review Date: 6/5/2012

          Reviewed By: David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine. Yi-Bin Chen, MD, Leukemia/Bone Marrow Transplant Program, Massachusetts General Hospital. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M. Health Solutions, Ebix, Inc.

          The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.
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