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    Euglobulin lysis time

    Euglobulin clot lysis; Fibrinolysis/euglobulin lysis; ELT

    Euglobulin lysis time (ELT) is a blood test that looks at how fast clots break down in the blood.

    How the Test is Performed

    A blood sample is needed. For information on how this is done, see Venipuncture

    The laboratory specialist will run tests on the blood sample to see how fast blood clots dissolve. The dissolving of blood clots is called fibrinolysis.

    How to Prepare for the Test

    No special preparation is usually needed.

    How the Test Will Feel

    When the needle is inserted to draw blood, some people feel moderate pain, while others feel only a prick or stinging sensation. Afterward, there may be some throbbing.

    Why the Test is Performed

    This is one of the best tests to tell the difference between primary fibrinolysis and disseminated intravascular coagulation.

    The test can also be used to monitor patients who are on streptokinase or urokinase therapy for acute MI (heart attack).

    Normal Results

    A normal value will range from 90 minutes to 6 hours. Euglobulin clot lysis is normally complete within 2 to 4 hours.

    Note: Normal value ranges may vary slightly among different laboratories. Talk to your doctor about the meaning of your specific test results.

    What Abnormal Results Mean

    A longer-than-normal ELT time may be due to:

    • Diabetes
    • Prematurity

    A shorter-than-normal ELT time may be due to:

    • Blood vessel injury or surgery
    • Cancer of the prostate
    • Cirrhosis
    • Fibrinogen deficiency
    • Leukemia
    • Pregnancy complications (for example, antepartum hemorrhage, hydatidiform mole, amniotic embolism)
    • Shock
    • Thrombocytopenia purpura

    The test may also be done to diagnose or rule out:

    • Spontaneous abortion
    • Primary thrombocythemia

    Risks

    There is very little risk involved with having your blood taken. Veins and arteries vary in size from one patient to another and from one side of the body to the other. Taking blood from some people may be more difficult than from others.

    Other risks associated with having blood drawn are slight but may include:

    • Excessive bleeding
    • Fainting or feeling light-headed
    • Hematoma (blood accumulating under the skin)
    • Infection (a slight risk any time the skin is broken)

    Considerations

    Heavy exercise can cause a shorter-than-normal ELT time.

    Increasing age and certain medicines, including corticosteroids, ACTH, streptokinase, and urokinase can cause a longer-than-normal ELT time.

    References

    Lijnen HR, Collen D. Molecular and cellular basis of fibrinolysis. In: Hoffman R, Benz EJ Jr., Shattil SJ, et al, eds. Hoffman Hematology: Basic Principles and Practice. 5th ed. Philadelphia, Pa: Churchill Livingstone Elsevier; 2008:chap 119.

    Schafer A. Hemorrhagic disorders: Disseminated intravascular coagulation, liver failure, and vitamin K deficiency. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 181.

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            Tests for Euglobulin lysis time

            Review Date: 2/28/2011

            Reviewed By: David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine; and Yi-Bin Chen, MD, Leukemia/Bone Marrow Transplant Program, Massachusetts General Hospital. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

            The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.
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