St. Luke's Hospital
Main Number: 314-434-1500 Emergency Dept: 314-205-6990 Patient Billing: 888-924-9200
Find a Physician Payment Options Locations & Directions
Follow us on: facebook twitter Mobile Email Page Email Page Print Page Print Page Increase Font Size Decrease Font Size Font Size
America's 50 Best Hospitals
Meet the Doctor
Spirit of Women
Community Health Needs Assessment
Home > Health Information

Multimedia Encyclopedia

    Print-Friendly
    Bookmarks

    Protein C

    Protein C is a substance that prevents blood clotting. A blood test can be done to see how much of this protein you have in your blood.

    How the Test is Performed

    A blood sample is needed. For information on how this is done, see: Venipuncture

    How to Prepare for the Test

    Certain drugs can interfere with this test. Be sure to tell your doctor about all medications and supplements you are taking before having this test.

    Some medicines that prevent blood clots from forming (anticoagulants), such as warfarin (Coumadin), decrease protein C and protein S levels. Your doctor may ask you to stop taking these medications for a time before the test.

    How the Test Will Feel

    When the needle is inserted to draw blood, some people feel moderate pain. Others feel only a prick or stinging sensation. Afterward, there may be some throbbing.

    Why the Test is Performed

    Your doctor may order this test if you have an unexplained blood clot, or a family history of blood clots. Protein C and protein S help regulate blood clotting. A lack of these proteins may cause blood clots to form in veins.

    The test is also used to screen relatives of patients with a known protein C deficiency. It may also be done to find the reason for repeated miscarriages.

    Normal Results

    Normal values are 60 - 150% inhibition.

    Note: Normal value ranges may vary slightly among different laboratories. Talk to your doctor about the meaning of your specific test results.

    The examples above show the common measurements for results for these tests. Some laboratories use different measurements or may test different specimens.

    What Abnormal Results Mean

    A lack (deficiency) of protein C can lead to excess clotting. These clots tend to form in veins, not arteries.

    Protein C deficiency can be passed down through families (inherited) or it can develop with other conditions, such as:

    • Chemotherapy use
    • Disseminated intravascular coagulation (DIC)
    • Liver disease
    • Long-term antibiotic use
    • Warfarin (Coumadin) use

    Protein C levels rise with age, but this does not cause any health problems.

    Risks

    There is very little risk involved with having your blood taken. Veins and arteries vary in size from one patient to another and from one side of the body to the other. Taking blood from some people may be more difficult than from others.

    Other risks associated with having blood drawn are slight but may include:

    • Excessive bleeding
    • Fainting or feeling light-headed
    • Hematoma (blood accumulating under the skin)
    • Infection (a slight risk any time the skin is broken)

    References

    Bauer KB. Hypercoagulable states. In: Hoffman R, Benz EJ Jr., Shattil SJ, et al, eds. Hoffman Hematology: Basic Principles and Practice. 5th ed. Philadelphia, Pa: Churchill Livingstone Elsevier; 2008:chap 134.

    Schafer A. Thrombotic disorders: Hypercoagulable states. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 182.

    BACK TO TOP

          A Closer Look

            Talking to your MD

              Self Care

                Tests for Protein C

                Review Date: 2/28/2011

                Reviewed By: David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine; and Yi-Bin Chen, MD, Leukemia/Bone Marrow Transplant Program, Massachusetts General Hospital. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

                The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.
                adam.com

                A.D.A.M. content is best viewed in IE9 or above, Fire Fox and chrome browser.


                Back  |  Top
                About Us
                Contact Us
                History
                Mission
                Locations & Directions
                Quality Reports
                Annual Reports
                Honors & Awards
                Community Health Needs
                Assessment

                Newsroom
                Services
                Brain & Spine
                Cancer
                Heart
                Maternity
                Orthopedics
                Pulmonary
                Sleep Medicine
                Urgent Care
                Women's Services
                All Services
                Patients & Visitors
                Locations & Directions
                Find a Physician
                Tour St. Luke's
                Patient & Visitor Information
                Contact Us
                Payment Options
                Financial Assistance
                Send a Card
                Mammogram Appointments
                Health Tools
                My Personal Health
                mystlukes
                Spirit of Women
                Health Information & Tools
                Clinical Trials
                Health Risk Assessments
                Employer Programs -
                Passport to Wellness

                Classes & Events
                Classes & Events
                Spirit of Women
                Donate & Volunteer
                Giving Opportunities
                Volunteer
                Physicians & Employees
                For Physicians
                Remote Access
                Medical Residency Information
                Pharmacy Residency Information
                Physician CPOE Training
                Careers
                Careers
                St. Luke's Hospital - 232 South Woods Mill Road - Chesterfield, MO 63017 Main Number: 314-434-1500 Emergency Dept: 314-205-6990 Patient Billing: 888-924-9200
                Copyright © St. Luke's Hospital Website Terms and Conditions  |  Privacy Policy  |  Patient Notice of Privacy Policies PDF Sitemap St. Luke's Mobile