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    Sickle cell test

    Sickledex; Hgb S test

    A sickle cell test looks for the abnormal hemoglobin in the blood that causes sickle cell anemia.

    How the Test is Performed

    A blood sample is needed. For information on how this is done, see: Venipuncture

    How the Test Will Feel

    When the needle is inserted to draw blood, some people feel moderate pain, while others feel only a prick or stinging sensation. Afterward, there may be some throbbing.

    Why the Test is Performed

    This test is done to tell if you have abnormal hemoglobin that causes sickle cell disease and sickle cell trait.

    In sickle cell disease, a person has two abnormal hemoglobin S genes. A person with sickle cell trait has only one of these abnormal genes and no symptoms, or only mild ones.

    This test does not tell the difference between these two conditions. Another test, called hemoglobin electrophoresis, will be done.

    Normal Results

    A negative test result is normal.

    Normal value ranges may vary slightly among different laboratories. Some labs use different measurements or test different samples.Talk to your doctor about the meaning of your specific test results.

    What Abnormal Results Mean

    • Sickle cell anemia
    • Sickle cell trait

    Risks

    Veins and arteries vary in size from one patient to another and from one side of the body to the other. Obtaining a blood sample from some people may be more difficult than from others.

    Other risks associated with having blood drawn are slight but may include:

    • Excessive bleeding
    • Fainting or feeling light-headed
    • Hematoma (blood accumulating under the skin)
    • Infection (a slight risk any time the skin is broken)

    Considerations

    Iron deficiency or blood transfusions within the past 3 months can cause a false negative result.

    References

    Steinberg MH. Sickle cell disease and associated hemoglobinopathies. In: Goldman L, Schafer AI, eds. Cecil Medicine. 24th ed. Philadelphia, Pa: Saunders Elsevier; 2011:chap 166.

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      A Closer Look

      Self Care

        Tests for Sickle cell test

        Review Date: 2/28/2011

        Reviewed By: Todd Gersten, MD, Hematology/Oncology, Palm Beach Cancer Institute, West Palm Beach, FL. Review provided by VeriMed Healthcare Network. Also reviewed by Linda J. Vorvick, MD, Medical Director and Director of Didactic Curriculum, MEDEX Northwest Division of Physician Assistant Studies, Department of Family Medicine, UW Medicine, School of Medicine, University of Washington; David Zieve, MD, MHA, Medical Director, A.D.A.M. Health Solutions, Ebix, Inc.

        The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.
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        St. Luke's Hospital - 232 South Woods Mill Road - Chesterfield, MO 63017 Main Number: 314-434-1500 Emergency Dept: 314-205-6990 Patient Billing: 888-924-9200
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