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    Erythropoietin test

    Serum erythropoietin; EPO

    The erythropoietin test measures the amount of a hormone called erythropoietin (EPO) in blood.

    The hormone tells stem cells in the bone marrow to make more red blood cells. EPO is made by cells in the kidney. These cells release more EPO when blood oxygen levels are low.

    See also: Reticulocyte count

    How the Test is Performed

    A blood sample is needed. For information on how this is done, see: Venipuncture

    How to Prepare for the Test

    No special preparation is necessary.

    How the Test Will Feel

    When the needle is inserted to draw blood, some people feel moderate pain, while others feel only a prick or stinging sensation. Afterward, there may be some throbbing.

    Why the Test is Performed

    This test may be used to help determine the cause of anemia, polycythemia (high red blood cell count) or other bone marrow disorders.

    A change in red blood cells will affect the release of EPO. For example, persons with anemia have too few red blood cells, so more EPO is produced.

    Normal Results

    The normal range is 0-19 milliunits per milliliter (mU/mL).

    The examples above are common measurements for results of these tests. Normal value ranges may vary slightly among different laboratories. Some labs use different measurements or test different samples. Talk to your doctor about the meaning of your specific test results.

    What Abnormal Results Mean

    Increased EPO levels may be due to secondary polycythemia, an overproduction of red blood cells that occurs in response to an event such as low blood oxygen levels. This may happen at high altitudes or, rarely, because of a tumor that releases EPO.

    Lower-than-normal EPO levels may be seen in chronic kidney failure, anemia of chronic disease, or polycythemia vera.

    Risks

    Veins and arteries vary in size from one patient to another and from one side of the body to the other. Obtaining a blood sample from some people may be more difficult than from others.

    Other risks associated with having blood drawn are slight but may include:

    • Excessive bleeding
    • Fainting or feeling light-headed
    • Hematoma (blood accumulating under the skin)
    • Infection (a slight risk any time the skin is broken)

    References

    Hoffman R, Xu M, Finazzi G, Barbui T. The polycythemias. In: Hoffman R, Benz EJ Jr, Shattil SJ, et al, eds. Hoffman Hematology: Basic Principles and Practice. 5th ed. Philadelphia, Pa: Churchill Livingstone Elsevier; 2008:chap 68.

    Kaushansky K. Hematopoiesis and hematopoietic growth factors. In: Goldman L, Schafer AI, eds. Cecil Medicine. 24th ed. Philadelphia, Pa: Saunders Elsevier; 2011:chap 159.

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              Review Date: 8/14/2011

              Reviewed By: David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

              The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.
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