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    T3RU test

    Resin T3 uptake; T3 resin uptake; Thyroid hormone-binding ratio

    The T3RU test measures the level of proteins that carry thyroid hormone in the blood. This can help your health care provider interpret the results of T3 and T4 blood tests. However, because the free T4 blood test is available, the T3RU test is rarely used anymore.

    How the Test is Performed

    A blood sample is needed. For information on how this is done, see: Venipuncture

    How to Prepare for the Test

    Your health care provider will tell you, if needed, to stop taking drugs that may interfere with the test.

    Drugs that can increase T3RU levels include:

    • Anabolic steroids
    • Heparin
    • Phenytoin
    • Salicylates (high dose)
    • Warfarin

    The following can increase thyroxin binding globulin (TBG) levels:

    • Male hormones (androgens)
    • Serious illness
    • Kidney disease

    Drugs that can decrease T3RU levels include:

    • Antithyroid medications
    • Birth control pills
    • Clofibrate
    • Estrogen
    • Thiazides

    Pregnancy can also decrease T3RU levels.

    How the Test Will Feel

    When the needle is inserted to draw blood, some people feel moderate pain, while others feel only a prick or stinging sensation. Afterward, there may be some throbbing.

    Why the Test is Performed

    This test is done to check your thyroid function. Thyroid function is complex and depends on the action of many different hormones, including thyroid-stimulating hormone (TSH), T3, and T4.

    This test helps see how much thyroxin binding globulin (TBG) is available. TBG is a protein that carries most of the T3 and T4 in the blood.

    The higher the level of TBG, the lower thelevel of T3RU. A higher T3RUlevel means less TBG is available. This may be caused by hyperthyroidism.

    Your doctor may order this test if you have signs of a thyroid disorder, including:

    • Hyperthyroidism
    • Hypothyroidism - primary
    • Hypothyroidism - secondary
    • Thyrotoxic periodic paralysis

    Normal Results

    Normal values range from 24 - 37%.

    The examples above are common measurements for resultsof these tests. Normal value ranges may vary slightly among different laboratories. Some labs use different measurements or test different samples.Talk to your doctor about the meaning of your specific test results.

    What Abnormal Results Mean

    Higher-than-normal levels may indicate:

    • Kidney failure
    • Overactive thyroid (hyperthyroidism)
    • Nephrotic syndrome
    • Protein malnutrition

    Lower-than-normal levels may indicate:

    • Acute hepatitis
    • Pregnancy
    • Underactive thyroid (hypothyroidism, primary hypothyroidism, or secondary hypothyroidism)
    • Use of estrogen

    Abnormal results may also be due to an inherited condition of high TBG levels. Usually thyroid function is normal in people with this condition.

    This test may also be done for:

    • Chronic thyroiditis (Hashimoto's disease)
    • Drug-induced hypothyroidism
    • Graves disease
    • Subacute thyroiditis
    • Thyrotoxic periodic paralysis
    • Toxic nodular goiter

    Risks

    Veins and arteries vary in size from one patient to another and from one side of the body to the other. Obtaining a blood sample from some people may be more difficult than from others.

    Other risks associated with having blood drawn are slight but may include:

    • Excessive bleeding
    • Fainting or feeling light-headed
    • Hematoma (blood accumulating under the skin)
    • Infection (a slight risk any time the skin is broken)

    References

    Kim M, Ladenson P. Thyroid. In: Goldman L, Schafer AI, eds. Cecil Medicine. 24th ed. Philadelphia, Pa: Saunders Elsevier; 2011:chap 233.

    Salvatore D, Davies TF, Schlumberger MJ, Hay ID, Larsen PR. Thyroid physiology and diagnostic evaluation of patients with thyroid disorders. In: Melmed S, Polonsky KS, Larsen PR, Kronenberg HM, eds. Williams Textbook of Endocrinology. 12th ed. Philadelphia, Pa: Saunders Elsevier; 2011:chap 11.

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              Tests for T3RU test

              Review Date: 6/26/2012

              Reviewed By: Shehzad Topiwala, MD, Chief Consultant Endocrinologist, Premier Medical Associates, The Villages, FL. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M. Health Solutions, Ebix, Inc.

              The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.
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