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    Secretin stimulation test

    Pancreatic function test

    The secretin stimulation test measures the ability of the pancreas to respond to a hormone called secretin. The small intestine produces secretin when partially digested food into the area from the stomach.

    How the Test is Performed

    The doctor insertsa tubethrough yournose and intoyour stomach. The tube is then moved into the first part of the small intestine (duodenum). You are give secretin through a vein (intravenously). The contents of the material released from the pancreas into the duodenum are removed through the tube over the next 1 - 2 hours.

    How to Prepare for the Test

    You will be asked to not eat or drink anything, including water, for 12 hours before the test.

    How the Test Will Feel

    You may have a gaggingfeeling as the tube is inserted.

    Why the Test is Performed

    Secretin causes the pancreas to release a fluid that containsdigestive enzymes. These enzymes break down food and help the body absorb nutrients.

    The secretin stimulation test is done to check the digestive function of the pancreas. The following diseases may prevent the pancreas from working properly:

    • Chronic pancreatitis
    • Cystic fibrosis
    • Pancreatic cancer

    In these conditions, there may be a lack of digestive enzymes or other chemicals in the fluid that comes from the pancreas. This can reduce the body's ability to digest food and absorb nutrients.

    Normal Results

    Normal value ranges may vary slightly depending on the lab doing the test. Talk to your doctor about the meaning of your specific test results.

    What Abnormal Results Mean

    Abnormal values may mean that the pancreas is not working properly.

    Risks

    There is a slight risk of the tube being placed through the windpipe and into the lungs, instead of through the esophagus and into the stomach.

    References

    Semrad CE. Approach to the patient with diarrhea and malabsorption. In: Goldman L, Schafer AI, eds. Cecil Medicine. 24th ed. Philadelphia, Pa: Saunders Elsevier; 2011: chap 142.

    Rao SSC. Pancreatic secretion. In: Feldman M, Friedman LS, Brandt LJ, eds. Sleisenger and Fordtran's Gastrointestinal and Liver Disease. 9th ed. Philadelphia, Pa: Saunders Elsevier; 2010:chap 56.

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          Review Date: 10/8/2012

          Reviewed By: George F. Longstreth, MD, Department of Gastroenterology, Kaiser Permanente Medical Care Program, San Diego, California. Also reviewed by A.D.A.M. Health Solutions, Ebix, Inc., Editorial Team: David Zieve, MD, MHA, David R. Eltz, and Stephanie Slon.

          The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.
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          St. Luke's Hospital - 232 South Woods Mill Road - Chesterfield, MO 63017 Main Number: 314-434-1500 Emergency Dept: 314-205-6990 Patient Billing: 888-924-9200
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