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    Aging changes in the heart and blood vessels

    Heart disease - aging; Atherosclerosis - aging

    Information

    Some changes in the heart and blood vessels normally occur with age, but many other changes that are common with aging are due to modifiable factors that, if not treated, can lead to heart disease.

    BACKGROUND

    The heart has two sides. The right side pumps blood to the lungs to receive oxygen and get rid of carbon dioxide. The left side pumps oxygen-rich blood to the body.

    Blood flows out of the heart through arteries, which branch out and get smaller and smaller as they go into the tissues. In the tissues, they become tiny capillaries.

    Capillaries are where the blood gives up oxygen and nutrients to the tissues, and receives carbon dioxide and wastes back from the tissues. Then, the vessels begin to collect together into larger and larger veins, which return blood to the heart.

    AGING CHANGES

    Heart

    • The heart has a natural pacemaker system that controls the heartbeat. Some of the pathways of this system may develop fibrous tissue and fat deposits. The natural pacemaker (the SA node) loses some of its cells. These changes may result in a slightly slower heart rate.
    • A slight increase in the size of the heart, especially the left ventricle, is not uncommon. The heart wall thickens, so the amount of blood that the chamber can hold may actually decrease despite the increased overall heart size. The heart may fill more slowly.
    • Heart changes cause the ECG of a normal, healthy older person to be slightly different than the ECG of a healthy younger adult. Abnormal rhythms (arrhythmias) such as atrial fibrillation are more common in older people. They may be caused by heart disease.
    • Normal changes in the heart include deposits of the "aging pigment," lipofuscin. The heart muscle cells degenerate slightly. The valves inside the heart, which control the direction of blood flow, thicken and become stiffer. A heart murmur caused by valve stiffness is fairly common in the elderly.

    Blood vessels

    • Receptors called baroreceptors monitor the blood pressure and make changes to help maintain a fairly constant blood pressure when a person changes positions or activities. The baroreceptors become less sensitive with aging. This may explain why many older people have orthostatic hypotension, a condition in which the blood pressure falls when a person goes from lying or sitting to standing. This causes dizziness because there is less blood flow to the brain.
    • The capillary walls thicken slightly. This may cause a slightly slower rate of exchange of nutrients and wastes.
    • The main artery from the heart (aorta) becomes thicker, stiffer, and less flexible. This is probably related to changes in the connective tissue of the blood vessel wall. This makes the blood pressure higher and makes the heart work harder, which may lead to thickening of the heart muscle (hypertrophy). The other arteries also thicken and stiffen. In general, most elderly people have a moderate increase in blood pressure.

    Blood

    • The blood itself changes slightly with age. Normal aging causes a reduction in total body water. As part of this, there is less fluid in the bloodstream, so blood volume decreases.
    • The speed with which red blood cells are produced in response to stress or illness is reduced. This creates a slower response to blood loss and anemia.
    • Most of the white blood cells stay at the same levels, although certain white blood cells important to immunity (neutrophils) decrease in their number and ability to fight off bacteria. This reduces the ability to resist infection.

    EFFECT OF CHANGES

    Normally, the heart continues to pump enough blood to supply all parts of the body. However, an older heart may not be able to pump blood as well when you make it work harder.

    Some of the things that make your heart work harder are:

    • Certain medications
    • Emotional stress
    • Extreme physical exertion
    • Illness
    • Infections
    • Injuries

    COMMON PROBLEMS

    • Angina (chest pain caused by temporarily reduced blood flow to the heart muscle), shortness of breath with exertion, and heart attack can result from coronary artery disease.
    • Abnormal heart rhythms (arrhythmias) of various types can occur.
    • Anemia may occur, possibly related to malnutrition, chronic infections, blood loss from the gastrointestinal tract, or as a complication of other diseases or medications.
    • Arteriosclerosis (hardening of the arteries) is very common. Fatty plaque deposits inside the blood vessels cause them to narrow and can totally block blood vessels.
    • Congestive heart failure is also very common in the elderly. In people older than 75, congestive heart failure occurs 10 times more often than in younger adults.
    • Coronary artery disease is fairly common. It is often a result of arteriosclerosis.
    • High blood pressure and orthostatic hypotension are more common with older age.
    • Heart valve diseases are fairly common. Aortic stenosis, or narrowing of the aortic valve, is the most common valve disease in the elderly.
    • Transient ischemic attacks (TIA) or strokes can occur if blood flow to the brain is disrupted.

    Other problems with the heart and blood vessels include the following:

    • Blood clots
      • Deep vein thrombosis
      • Thrombophlebitis
    • Peripheral vascular disease, resulting in intermittent pain in the legs when walking (claudication)
    • Varicose veins

    PREVENTION

    You can help your circulatory system (heart and blood vessels). Heart disease risk factors that you have some control over include high blood pressure, cholesterol levels, diabetes, obesity, and smoking.

    • Eat a heart-healthy diet with reduced amounts of saturated fat and cholesterol, and control your weight. Follow your health care provider's recommendations for treating high blood pressure, high cholesterol, or diabetes. Reduce or stop smoking.
    • Exercise may help prevent obesity, and it helps people with diabetes control their blood sugar.
    • Exercise may help you maintain your abilities as much as possible and it reduces stress.
    • Have regular check-ups for your heart:
      • Have your blood pressure checked every year. If you have diabetes, heart disease, kidney problems, or certain other conditions, your blood pressure may need to be monitored more closely.
      • If your cholesterol level is normal, have it rechecked every 5 years. If you have diabetes, heart disease, kidney problems, or certain other conditions, your cholesterol may need to be monitored more closely.
    • Moderate exercise is one of the best things you can do to keep your heart, and the rest of your body, healthy. Consult with your health care provider before beginning a new exercise program. Exercise moderately and within your capabilities, but do it regularly.
    • People who exercise usually have less body fat and smoke less than people who do not exercise. They also tend to have fewer blood pressure problems and less heart disease.

    References

    Minaker KL. Common clinical sequelae of aging. In Goldman L, Schafer AI, eds. Cecil Medicine. 24th ed. Philadelphia, Pa: Saunders Elsevier;2011:chap 24.

    Schwartz JB, Zipes DP. Cardiovascular disease in the elderly. In: Bonow RO, Mann DL, Zipes DP, Libby P, eds. Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine. 9th ed. Philadelphia, Pa:Saunders; 2011:chap 80.

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    • Blood flow

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    • Atherosclerosis overview

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    • Taking your carotid puls...

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    • Circulation of blood thr...

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    • Radial pulse

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    • Normal heart anatomy (cu...

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    • Effects of age on blood ...

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    • Blood flow

      Animation

    • Atherosclerosis overview

      Animation

    • Taking your carotid puls...

      illustration

    • Circulation of blood thr...

      illustration

    • Radial pulse

      illustration

    • Normal heart anatomy (cu...

      illustration

    • Effects of age on blood ...

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    A Closer Look

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        Tests for Aging changes in the heart and blood vessels

          Review Date: 9/4/2012

          Reviewed By: David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M. Health Solutions, Ebix, Inc.

          The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.
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