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    Fuchs' dystrophy

    Fuchs' endothelial dystrophy, Fuchs' corneal dystrophy

    Fuchs' (pronounced Fooks) dystrophy is an eye disease in which cells lining the inner surface of the cornea slowly start to die off. The disease usually affects both eyes.


    Fuchs' dystrophy can be inherited, which means it can be passed down from parents to children. If either of your parents has the disease, you have a 50% chance of developing the condition.

    However, the condition may also occur in persons without a known family history of the disease.

    Fuchs' dystrophy is more common in women than in men. Vision problems usually do not appear before age 50, although doctors may be able to see signs of the disease in affected persons at an earlier age, usually in their 30s and 40s.

    Fuchs' dystrophy affects the thin layer of cells that line the back part of the cornea. These cells help pump excess fluid out of the cornea. As more and more cells are lost, fluid begins to build up in the cornea, causing swelling and a cloudy cornea.

    At first, fluid may build up only during sleep, when the eye is closed. As the disease gets worse, small blisters may form. The blisters get bigger and may eventually break, causing eye pain. Fuchs' dystrophy can also cause the shape of the cornea to change, causing further vision problems.


    • Eye pain
    • Eye sensitivity to lightand glare
    • Foggy or blurred vision, at first only in the mornings
    • Seeing colored halos around lights
    • Worsening vision throughout the day

    Exams and Tests

    A doctor can diagnose Fuchs' dystrophy during a slit-lamp examination.

    Additional tests that may be done include:

    • Pachymetry -- measures the thickness of the cornea
    • Specular microscope examination -- allows the doctor to look at thin layer of cells that line the back part of the cornea
    • Visual acuity test


    Eye drops or ointments that draw fluid out of the cornea are used to relieve symptoms of Fuchs' dystrophy.

    If painful sores develop on the cornea, soft contact lenses or surgery to create flaps over the sores may help reduce pain.

    The only cure for Fuchs' dystrophy is a corneal transplant.

    Deep lamellar keratoplasty (DLK) is an alternative to a traditional transplant. In this procedure, only the deep layers of the cornea are replaced with donor tissue. The procedure requires no stitches. Recovery time is faster and there are fewer complications, such as rejection.

    Outlook (Prognosis)

    Fuchs' dystrophy gets worse over time. Without a corneal transplant, a patient with severe Fuchs' dystrophy may become blind or have severe pain and very reduced vision.

    Mild cases of Fuchs' dystrophy often worsen after cataract surgery. A cataract surgeon will evaluate this risk and may modify the technique or the timing of your cataract surgery.

    Possible Complications

    When to Contact a Medical Professional

    Call your health care provider if you have:

    • Eye pain
    • Eye sensitivity to light
    • The feeling that something is in your eye when there is nothing there
    • Vision problems such as seeing halos or cloudy vision
    • Worsening vision



    Cockerham GC, Kenyon KR. The corneal dystrophies. In: Tasman W, Jaeger EA, eds. Duane’s Ophthalmology. 15th ed. Philadelphia, Pa: Lippincott Williams & Wilkins; 2009:chap 16.

    Vanmeter WS, Lee WB, Katz DG. Corneal edema. In: Tasman W, Jaeger EA, eds. Duane’s Ophthalmology. 15th ed. Philadelphia, Pa: Lippincott Williams & Wilkins; 2009:chap 16A.


          Tests for Fuchs' dystrophy

            Review Date: 9/17/2012

            Reviewed By: David Zieve, MD, MHA, Medical Director, A.D.A.M. Health Solutions, Ebix, Inc. Franklin W. Lusby, MD, Ophthalmologist, Lusby Vision Institute, La Jolla, California.

            The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.

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