If you are currently being treated with any of the following medications, you should not use lipase without first talking to your health care provider.
Orlistat -- Orlistat (Xenical, also available as alli in non-prescription form) interferes with the activity of lipase supplements. Orlistat is a medication used to treat obesity that blocks the ability of lipase to break down fats.
Digestive enzymes -- Digestive enzymes, including papain, pepsin, betaine HCL, and hydrochloric acid, can destroy the lipase enzymes. However, enteric-coated lipase enzyme products are protected against destruction by stomach acid.