Autism
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Autism

Also listed as: Pervasive developmental disorder

Signs and Symptoms
Causes
Risk Factors
Diagnosis
  
Treatment Approach
Treatment Options
Prognosis/Possible Complications
Following Up
Other Considerations
Supporting Research

Children with autism have trouble with social and communication skills -- most often, social interactions, language, and behavior, including repeating a behavior over and over. Autism is among a group of complex developmental disorders called autism spectrum disorders. Autism appears in the first 3 years of life, although it is sometimes diagnosed much later.

Researchers don’t know what causes autism. Although there has been a lot of press about whether vaccines can trigger autism, many well-designed studies have found no link between autism and vaccines.

Autism has no cure, but early and aggressive intervention may help parents and children learn to manage symptoms and improve their quality of life.

Signs and Symptoms

The symptoms may vary from moderate to severe. Each child’s behavior is different, but here are some common signs in the three areas most likely to be affected -- language, social interaction, and behavior:

Communication:

  • Can’t start or keep a social conversation going
  • Develops language slowly or not at all
  • Repeats words or memorized passages, like commercials, but doesn’t understand them
  • Doesn’t refer to self correctly -- for example, says "you want water" when the child means "I want water"
  • Uses nonsense rhyming
  • Uses gestures instead of words

Social interaction:

  • Doesn’t seem aware of others’ feelings
  • Is withdrawn
  • Prefers to spend time alone, rather than with others
  • May not respond to eye contact or smiles
  • May avoid eye contact
  • Doesn’t like to be held
  • Doesn’t respond to his name

Behavior:

  • Repeats body movements
  • May find normal noises painful and hold hands over ears
  • May be sensitive to light
  • May find even slight touch to be overstimulating
  • Rubs surfaces, mouths or licks objects
  • Doesn’t like even the smallest changes in routine; needs everything to be the same
  • "Acts up" with intense tantrums

Causes

Researchers don’t know what causes autism, and there may be several causes. It may run in some families, and research shows that a number of genes may be involved.

Many other possible causes have been suspected, but not proven. Some researchers believe that damage to a specific part of the brain, called the amygdala, may be involved. Other researchers are looking at whether a virus may trigger symptoms.

Some parents have heard that the measles, mumps, and rubella (MMR) vaccine that children receive may cause autism. Several major studies have found no connection between the vaccine and autism. The American Academy of Pediatrics and the Centers for Disease Control and Prevention report that there is no link between autism and the MMR vaccine.

Some doctors think the increase in the number of children with autism is due to better diagnosis and newer definitions of autism. The term “autism spectrum disorders” now includes a wider range of developmental problems.

Risk Factors

Autism is four times more likely to develop in boys than in girls, and it may be inherited. In fact, about 50% of all boys with autism have a parent with the disease.

Autism occurs more often in children with rare genetic disorders and other medical conditions, such as tuberous sclerosis, phenylketonuria, neurofibromatosis, and epilepsy.

Some research suggests that children born to older fathers (over age 40) may be more likely to develop autism.

Diagnosis

There is no specific test to diagnose autism. Children develop at different rates, and your child's pediatrician will look at your child’s development during regular check-ups. Your child may need further evaluation if the child:

  • Isn’t babbling by 12 months
  • Doesn’t gesture (pointing, waving bye-bye) by 12 months
  • Isn’t saying single words by 16 months
  • Doesn’t say two-word spontaneous phrases by 24 months (not just echoing)
  • Loses any language or social skills at any age

Children with known or suspected autism will often have genetic testing to look for chromosome abnormalities and perhaps metabolic testing.

Treatment Approach

Children with autism do best with an early, intensive, appropriate treatment program. An experienced specialist or team should create a program specifically for your child. Many effective therapies are available. The best treatment plan may use a combination of these.

Teaching Programs

There are many types of educational programs for children with autism. Many children do well with very structured programs that reinforce the learning and practice of certain skills. When started early (pre-school) these programs may help a child advance in development and learn to function well.

Medications

Medicines are often used to treat behavior or emotional problems that people with autism may have. These include hyperactivity, impulsiveness, attention problems, irritability, mood swings, outbursts, tantrums, aggression, sleep problems, and anxiety.

Treatment Options

Diet

Some children with autism seem to respond to a gluten-free or a casein-free diet. Gluten is found in foods containing wheat, rye, and barley. Casein is found in milk, cheese, and other dairy products.

Not all experts agree that changing a child's diet will make a difference, and a review of studies in 2008 found no evidence that the diets helped. However, some parents say they do see a difference in their children’s behavior. If you want to try a special diet, talk to a registered dietitian who has experience working with children with autism.

Some studies have suggested that vitamin B6 and vitamin C may help some children with autism. The studies examining whether vitamin B6 may help used doses that are higher than the recommended amount -- enough to be potentially toxic. Do not give these doses except under a doctor’s supervision.

Some doctors suggest adding magnesium to vitamin B6 because they think the combination may work better, although two studies did not find any benefit.

One small study found that vitamin C supplements may help improve behavior in children with autism. The amounts used were high enough to possibly cause diarrhea. More research is needed on vitamin C and autism.

One small study found that taking a multivitamin improved sleep and digestive problems in children with autism.

If you are considering these supplements, it is important to talk with your doctor, a gastroenterologist (doctor who specializes in the digestive system), and a registered dietitian. You want to be sure that your child is still receiving enough calories, nutrients, and a balanced diet, and is not taking too much of a supplement.

Touch Therapy and Massage

Research shows that some children with autism have fewer symptoms after several weeks of touch therapy. In one clinical study, after 16 weeks of massage therapy for their children, parents said they felt physically and emotionally closer to their children and the children gave a range of cues to start massage at home.

Several clinical studies have found that children who had Qigong massage, a type of massage that focuses on energy, showed an improvement in behavior and an increase in language development. They also had improvement in motor skills, sensory function, and general health.

Art, Music, and Pet Therapy

Art therapy, music therapy, animal therapy, and sensory integration therapy provide opportunities for children who have autism to develop social and communication skills.

Art therapy offers a child a way to express his or her feelings without using words.

Music therapy including singing helps develop speech and language skills. In fact, research shows that any music therapy may reduce symptoms for children and adolescents with autism.

Animal therapy may include therapeutic horse riding programs and swimming with dolphins. These types of therapies can help improve motor skills, while also building self-confidence. Some studies suggest that children who interact with dolphins learn faster and retain more information than children who learned in a classroom setting.

Sensory integration focuses on helping children reorganize and integrate what they perceive with their senses so they can better understand the outside world.

While there is little scientific evidence to say these therapies work, many parents and therapists say their child’s behavior and communication skills improve, and that the children seem to enjoy these therapies.

Prognosis/Possible Complications

Autism is a challenging condition for children and their families, but the outlook is much better than it was a generation ago. Today, doctors and therapists can help manage many of the symptoms of autism, though most people will still have some symptoms throughout their lives.

Autism can be associated with other disorders that affect the brain, such as mental disability or fragile X syndrome. Some people with autism may have seizures.

Many families find a support group helps them cope with the challenges of autism.

Following Up

You will need a team of educational and medical professionals to help treat a child with autism. It is important to find teachers, doctors, and behavioral specialists who can help you navigate the medical and educational landscape. They can help you find out what legal and financial options exist for schooling and treating children with disabilities.

Other Considerations

Viral infection during the first three months of pregnancy -- particularly with rubella -- is a suspected cause of autism.

Supporting Research

Abbey D. Helping families find the best evidence: CAM therapies for autism spectrum disorders and Asperger's Disorder. J Spec Pediatr Nurs. 2009 Jul;14(3):200-2.

Adams JB et al., Pilot study of a moderate dose multivitamin-mineral supplement for children with autistic spectrum disorder. J Altern Complement Med. 2004 Dec;10(6):1033-9.

Adams et al, Abnormally high plasma levels of vitamin B6 in children with autism not taking supplements compared to controls not taking supplements. J Altern Complement Med. 2006 Jan-Feb;12(1):59-63.

Angley M, Semple S, Hewton C, Paterson F. Children and autism - management with complementary medicines and dietary interventions. Aust Fam Physician. 2007 Oct;36(10):827-30.

Cullen L, Barlow J. Kiss, cuddle, squeeze: the experiences and meaning of touch among parents of children with autism attending a Touch Therapy Programme. J Child Health Care. 2002;6(3):171-181.

Smeeth L, Cook C, Fombonne E, et al. MMR vaccination and pervasive developmental disorders: a case-control study. Lancet. 2004;364: 963–969.

Cullen-Powell LA, Barlow JH, Cushway D. Exploring a massage intervention for parents and their children with autism: the implications for bonding and attachment. J Child Health Care. 2005;9(4):245-55.

Cullen LA, Barlow JH, Cushway D. Positive touch, the implications for parents and their children with autism: an exploratory study. Complement Ther Clin Pract. 2005;11(3):182-9.

Elder JH, Shankar M, Shuster J, Theriaque D, Burns S, Sherrill L. The gluten-free, casein-free diet in autism: results of a preliminary double blind clinical trial. J Autism Dev Disord. 2006 Apr;36(3):413-20.

Gillberg C, Cederlund M. Asperger syndrome: familiar and pre- and perinatal factors. J Autism Dev Disord. 2005;35(2):159-166.

Kim J, Wigram T, Gold C. Emotional, motivational and interpersonal responsiveness of children with autism in improvisational music therapy. Autism. 2009 Jul;13(4):389-409.

Larsson HJ, Eaton WW, Madsen, KM, Vestergaard M, Olsen AV, Agerbo E, Schendel D, Thorsen P, Mortensen PB. Risk factors for autism: perinatal factors, parental psychiatric history and socioeconomic status. Am. J Epidemiol. 2005;161(10):916-925.

Malone RP, Gratz SS, Delaney MA, Hyman SB. Advances in drug treatments for children and adolescents with autism and other pervasive developmental disorders. CNS Drugs. 2005;19(11):923-34.

McGinnis WR. Oxidative stress in autism. Altern Ther Health Med. 2004;10(6):22-36.

Myers SM. The status of pharmacotherapy for autism spectrum disorders. Expert Opin Pharmacother. 2007 Aug;8(11):1579-603.

Nye C, Brice A, Nye C. Combined vitamin B6-magnesium treatment in autism spectrum disorder. Cochrane Database Syst Rev. 2005;(4):CD003497.

Potts M, Bellows B. Autism and diet. J Epidemiol Community Health. 2006 May;60(5):375.

Rossignol DA. Novel and emerging treatments for autism spectrum disorders: a systematic review. Ann Clin Psychiatry. 2009 Oct-Dec;21(4):213-36.

Schuchardt JP, Huss M, Stauss-Grabo M, Hahn A. Significance of long-chain polyunsaturated fatty acids (PUFAs) for the development and behaviour of children. Eur J Pediatr. 2009 Aug 12. [Epub ahead of print]

Silva LM, Cignolini A. A medical qigong methodology for early intervention in autism spectrum disorder: a case series. Am J Chin Med. 2005;33(2):315-27.

Silva LM, Cignolini A, Warren R, Budden S, Skowron-Gooch A. Improvement in sensory impairment and social interaction in young children with autism following treatment with an original Qigong massage methodology. Am J Chin Med. 2007;35(3):393-406.

Silva LM, Schalock M, Ayres R, Bunse C, Budden S. Qigong massage treatment for sensory and self-regulation problems in young children with autism: a randomized controlled trial. Am J Occup Ther. 2009 Jul-Aug;63(4):423-32.

Volkmar FR, Wiesner LA, Westphal A. Healthcare issues for children on the autism spectrum. Curr Opin Psychiatry. 2006 Jul;19(4):361-6.

Wills S, Cabanlit M, Bennett J, Ashwood P, Amaral D, Van de Water J. Autoantibodies in autism spectrum disorders (ASD). Ann N Y Acad Sci. 2007 Jun;1107:79-91.

Whipple J. Music intervention for children and adolescents with autism: a meta-analysis. J Music Ther. 2004;41(2):90-106.


Review Date: 12/30/2011
Reviewed By: Steven D. Ehrlich, NMD, Solutions Acupuncture, a private practice specializing in complementary and alternative medicine, Phoenix, AZ. Review provided by VeriMed Healthcare Network.
The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.
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