Locations Main Campus: Chesterfield, MO 63017   |   Locations
314-434-1500 314-434-1500   |   Contact Us

Multimedia Encyclopedia

E-mail Form
Email Results


MMRV (measles, mumps, rubella, and varicella) vaccine - what you need to know


All content below is taken in its entirety from the CDC MMRV (Measles, Mumps, Rubell and Varicella) Vaccine Information Statement (VIS): www.cdc.gov/vaccines/hcp/vis/vis-statements/mmrv.html

CDC review information for the MMRV VIS:

  • Page last reviewed: June 13, 2014
  • Page last updated: June 18, 2013
  • Issue date of VIS: May 21, 2010

Content source: National Center for Immunization and Respiratory Diseases


Measles, Mumps, Rubella & Varicella

Measles, Mumps, Rubella, and Varicella (chickenpox) can be serious diseases:


  • Causes rash, cough, runny nose, eye irritation, fever.
  • Can lead to ear infection, pneumonia, seizures, brain damage, and death.


  • Causes fever, headache, swollen glands.
  • Can lead to deafness, meningitis (infection of the brain and spinal cord covering), infection of the pancreas, painful swelling of the testicles or ovaries, and, rarely, death.

Rubella (German Measles)

  • Causes rash and mild fever; and can cause arthritis, (mostly in women).
  • If a woman gets rubella while she is pregnant, she could have a miscarriage or her baby could be born with serious birth defects.

Varicella (Chickenpox)

  • Causes rash, itching, fever, tiredness.
  • Can lead to severe skin infection, scars, pneumonia, brain damage, or death.
  • Can re-emerge years later as a painful rash called shingles.

These diseases can spread from person to person through the air. Varicella can also be spread through contact with fluid from chickenpox blisters.

Before vaccines, these diseases were very common in the United States.

MMRV Vaccine

MMRV vaccine may be given to children from 1 through 12 years of age to protect them from these four diseases.

Two doses of MMRV vaccine are recommended:

  • The first dose at 12 through 15 months of age
  • The second dose at 4 through 6 years of age

These are recommended ages. But children can get the second dose up through 12 years as long as it is at least 3 months after the first dose.

Children may also get these vaccines as 2 separate shots: MMR (measles, mumps and rubella) and varicella vaccines.

1 Shot (MMRV) or 2 Shots (MMR & Varicella)?

  • Both options give the same protection.
  • One less shot with MMRV.
  • Children who got the first dose as MMRV have had more fevers and fever-related seizures (about 1 in 1,250) than children who got the first dose as separate shots of MMR and varicella vaccines on the same day (about 1 in 2,500).

Your doctor can give you more information, including the Vaccine Information Statements for MMR and Varicella vaccines.

Anyone 13 or older who needs protection from these diseases should get MMR and varicella vaccines as separate shots.

MMRV may be given at the same time as other vaccines.

Some children should not get MMRV vaccine or should wait.

Children should not get MMRV vaccine if they:

  • Have ever had a life-threatening allergic reaction to a previous dose of MMRV vaccine, or to either MMR or varicella vaccine.
  • Have ever had a life-threatening allergic reaction to any component of the vaccine, including gelatin or the antibiotic neomycin. Tell the doctor if your child has any severe allergies.
  • Have HIV/AIDS, or another disease that affects the immune system.
  • Are being treated with drugs that affect the immune system, including high doses of oral steroids for 2 weeks or longer.
  • Have any kind of cancer
  • Are being treated for cancer with radiation or drugs

Check with your doctor if the child:

  • Has a history of seizures, or has a parent, brother or sister with a history of seizures.
  • Has a parent, brother or sister with a history of immune system problems.
  • Has ever had a low platelet count, or another blood disorder.
  • Recently had a transfusion or received other blood products.
  • Might be pregnant.

Children who are moderately or severely ill at the time the shot is scheduled should usually wait until they recover before getting MMRV vaccine. Children who are only mildly ill may usually get the vaccine.

Ask your doctor for more information.

What are the risks from MMRV vaccine?

A vaccine, like any medicine, is capable of causing serious problems, such as severe allergic reactions. The risk of MMRV vaccine causing serious harm, or death, is extremely small.

Getting MMRV vaccine is much safer than getting measles, mumps, rubella, or chickenpox.

Most children who get MMRV vaccine do not have any problems with it.

Mild problems

  • Fever (about 1 child out of 5).
  • Mild rash (about 1 child out of 20).
  • Swelling of glands in the cheeks or neck (rare).

If these problems happen, it is usually within 5 to 12 days after the first dose. They happen less often after the second dose.

Moderate problems

  • Seizure caused by fever (about 1 child in 1,250 who get MMRV), usually 5 to 12 days after the first dose. They happen less often when MMR and varicella vaccines are given at the same visit as separate shots (about 1 child in 2,500 who get these two vaccines), and rarely after a 2nd dose of MMRV.
  • Temporary low platelet count, which can cause a bleeding disorder (about 1 child out of 40,000).

Severe problems (very rare)

Several severe problems have been reported following MMR vaccine, and might also happen after MMRV. These include severe allergic reactions (fewer than 4 per million), and problems such as:

  • Deafness.
  • Long-term seizures, coma, lowered consciousness.
  • Permanent brain damage.

Because these problems occur so rarely, we can't be sure whether they are caused by the vaccine or not.

What if there is a serious reaction?

What should I look for?

  • Look for anything that concerns you, such as signs of a severe allergic reaction, very high fever, or behavior changes.

Signs of a severe allergic reaction can include hives, swelling of the face and throat, difficulty breathing, a fast heartbeat, dizziness, and weakness. These would start a few minutes to a few hours after the vaccination.

What should I do?

  • If you think it is a severe allergic reaction or other emergency that can't wait, call 9-1-1 or get the person to the nearest hospital. Otherwise, call your doctor.
  • Afterward, the reaction should be reported to the Vaccine Adverse Event Reporting System (VAERS). Your doctor might file this report, or you can do it yourself through the VAERS website or by calling 1-800-822-7967 .

VAERS is only for reporting reactions. They do not give medical advice.

The National Vaccine Injury Compensation Program

The National Vaccine Injury Compensation Program (VICP) is a federal program that was created to compensate people who may have been injured by certain vaccines.

Persons who believe they may have been injured by a vaccine can learn about the program and about filing a claim by calling 1-800-338-2382 or visiting the VICP website .

How can I learn more?



Vaccine information statement: MMRV vaccine (measles, mumps, rubella, and varicella). Centers for Disease Control and Prevention Web site. www.cdc.gov/vaccines/hcp/vis/vis-statements/mmrv.html . Accessed April 15, 2016.


        A Closer Look


        Talking to your MD


          Self Care


            Tests for MMRV (measles, mumps, rubella, and varicella) vaccine - what you need to know



              Review Date: 4/15/2016

              Reviewed By: David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team.

              The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.




              A.D.A.M. content is best viewed in IE9 or above, Firefox and Google Chrome browser.

              Content is best viewed in IE9 or above, Firefox and Google Chrome browser.