Obstructive sleep apnea
Obstructive Sleep Apnea
Obstructive sleep apnea is a common sleep disorder. It occurs when tissues in the upper airways come too close to each other during sleep, temporarily blocking the inflow of air.
Who Is At Risk
Obstructive sleep apnea can develop in anyone at any age but most often occurs in people who are:
- Age 40 and older
Sleep Apnea Symptoms
Symptoms of sleep apnea include:
- Excessive daytime sleepiness
- Morning headaches
- Impaired emotional or mental functioning
Patients with sleep apnea may find these lifestyle changes helpful:
- Sleep on your side, not your back. Special pillows can help maintain this position.
- If you smoke, quit.
- Do not drink alcohol within 4 hours of bedtime.
- If you are overweight, reduce. Even a small amount of weight loss may improve sleep apnea symptoms.
The treatment of obstructive sleep apnea depends in part on the severity of the condition. Treatment options include:
- Breathing devices. Continuous positive airway pressure (CPAP) devices are the most common treatment for moderate-to-severe obstructive sleep apnea. Although these devices can take some time to get used to, they are a very effective treatment.
- Dental devices. Dental devices, also called oral appliances, are custom-made mouthpieces that help position the lower jaw and tongue during sleep. Dental devices may be helpful for mild cases of obstructive sleep apnea.
- Surgery. Various surgical procedures may be recommended for very severe cases of obstructive sleep apnea but there is limited evidence for their effectiveness.
Obstructive sleep apnea (OSA) is a disorder in which a person temporarily stops breathing during the night, perhaps hundreds of times. These gaps in breathing are called apneas. The word apnea means absence of breath. An obstructive apnea episode is defined as the absence of airflow for at least 10 seconds.
Sleep apnea is usually accompanied by snoring, disturbed sleep, and daytime sleepiness. People might not even know they have the condition.
Obstructive sleep apnea (OSA) occurs when tissues in the upper throat relax and come together during sleep, temporarily blocking the passage of air. In general, OSA occurs as follows:
- On its way to the lungs, air passes through the nose, mouth, and throat (the upper airway).
- Under normal conditions, the back of the throat is soft and tends to collapse inward as a person breathes.
- Dilator (widening) muscles work against this collapse to keep the airway open. Interference or abnormalities in this process cause air turbulence.
- If the tissues at the back of the throat collapse and momentarily block the airway, apnea occurs. Breath is temporarily stopped. In most cases the person is unaware of it, although sometimes they awaken and gasp for breath.
- In some cases, the interference is incomplete (called obstructive hypopnea) and causes continuous but slow and shallow breathing. In response, the throat vibrates and makes the sound of snoring. Snoring can occur whether a person breathes through the mouth or the nose. (Snoring often occurs without apnea.)
- Apnea decreases the amount of oxygen in the blood, and eventually this lack of oxygen triggers the lungs to suck in air.
- At this point, the patient may make a gasping or snorting sound but does not usually fully wake up.
Obstructive sleep apnea is defined as five or more episodes of apnea or hypopnea per hour of sleep (called apnea-hypopnea index or AHI) in individuals who have excessive daytime sleepiness. Patients with 15 or more episodes of apnea or hypopnea per hour of sleep are considered to have moderate sleep apnea.
- Central sleep apnea is much less common. It is caused by a problem in the central nervous system, most often a failure of the brain to signal the airway muscles to breathe. In such cases, oxygen levels drop abruptly and usually the sleeper wakes with a start. Often people with central sleep apnea recall waking up. They generally experience less sleepiness during the day than people with obstructive sleep apnea. Heart disease, and, in particular, heart failure, is the most common cause of central sleep apnea.
- Mixed apnea is the term used when central and obstructive sleep apneas occur together.
- Upper airway resistance syndrome (UARS) is a condition in which patients snore, wake frequently during the night, and have excessive daytime sleepiness. However, patients do not have the breathing abnormalities that characterize sleep apnea and they do not show a reduction in blood oxygen levels. Unlike apnea, UARS is more likely to occur in women than in men. Treatments are similar to those of sleep apnea.
All of the muscles in the body relax during sleep. In people without obstructive sleep apnea, the throat muscles relax but do not block the airways. In patients with obstructive sleep apnea, the airways do become temporarily blocked or narrowed during sleep, reducing air pressure and preventing air from flowing normally into the lungs.
Certain physical characteristics of the face, skull, and neck can affect the size of the airway.
Large Neck. A large neck (17 inches or greater in men and 16 inches or greater in women) is a risk factor for sleep apnea. While some people’s necks are naturally larger than others, being overweight or obese can contribute to having a large neck.
Facial and Skull Characteristics. Structural abnormalities in the face and skull contribute to many cases of sleep apnea. These include:
- Undersized or receding lower jaw or chin (micrognathia)
- Jutting lower jaw (retrognathia)
- Narrow upper jaw
- Enlarged tongue
- Enlarged tonsils
Soft Palate Characteristics. Some people have specific abnormalities in the soft area (palate) at the back of the mouth and throat that may lead to sleep apnea. These abnormalities include:
- The soft palate is stiffer, larger than normal, or both. An enlarged soft palate may be a significant risk factor for sleep apnea.
- The soft palate and the walls of the throat around it collapse easily.
Muscle Weakness. Abnormalities or weakness in the muscles that surround the airway can also contribute to obstructive sleep apnea.
Sleep apnea occurs in about 2% of children and can occur even in very young children. The most likely causes include:
- Facial or skull abnormalities in infants such as brachycephaly, a birth defect in which the head tends to be shorter or wider than average.
- Overgrown tonsils, adenoids, or both in small children. (Removal of tonsils or adenoids can free the airways and may solve the problem.)
- Neuromuscular disorders that affect the muscles in the airways.
Obstructive sleep apnea is more common in men than in women. Men tend to have larger necks and weigh more than women. However, women tend to gain weight and develop larger necks after menopause, which increases their risk of developing sleep apnea.
Sleep apnea is most common in adults ages 40 - 60 years old. Middle age is also when symptoms are worse. Nevertheless, sleep apnea can affect people of all ages.
African-Americans face a higher risk for sleep apnea than any other ethnic group in the United States. Other groups at increased risk include Pacific Islanders and Mexicans.
People with a family history of obstructive sleep apnea are at increased risk of developing the condition.
Obesity is a particular risk factor for sleep apnea, even in adolescents and children. Obesity can contribute to sleep apnea when fat deposits fill throat tissue.
Smoking. Smokers are at higher risk for apnea. Those who smoke more than two packs a day have a risk 40 times greater than nonsmokers.
Alcohol. Alcohol use may be associated with apnea. Patients diagnosed with sleep apnea are recommended not to drink alcohol before bedtime.
Diabetes. Diabetes is associated with sleep apnea and snoring. It is not clear if there is an independent relationship between the two conditions or whether obesity is the only common factor.
Gastroesophageal Reflux Disease (GERD). GERD is a condition caused by acid backing up into the esophagus. It is a common cause of heartburn. GERD and sleep apnea often coincide. Research suggests that the backup of stomach acid in GERD may produce spasms in the vocal cords (larynx), thereby blocking the flow of air to the lungs and causing apnea. Apnea itself may also cause pressure changes that trigger GERD. Obesity is common in both conditions, and more research is needed to clarify the association.
Polycystic Ovary Syndrome (PCOS). Obstructive sleep apnea and excessive daytime sleepiness appear to be associated with polycystic ovary syndrome (PCOS), a female endocrine disorder. About half of patients with PCOS also have diabetes. Obesity and diabetes are associated with both sleep apnea and PCOS and may be the common factors.
Sleep apnea can lead to a number of complications, ranging from daytime sleepiness to possible increased risk of death. Sleep apnea has a strong association with several diseases, particularly those related to the heart and circulation.
Daytime sleepiness is the most noticeable, and one of the most serious, complications of sleep apnea. It interferes with mental alertness and quality of life. Daytime sleepiness can also increase the risk for accident-related injuries. Several studies have suggested that people with sleep apnea have two to three times as many car accidents, and five to seven times the risk for multiple accidents. Undertreated sleep apnea is a major risk factor for injury at factory and construction work sites.
Sleep-disordered breathing is very common among patients with heart problems such as high blood pressure, heart failure, stroke, heart attack, and atrial fibrillation. This link may be because both cardiovascular conditions and sleep apnea share a common risk factor of obesity. However, increasing evidence suggests that severe OSA is an independent risk factor that may cause or worsen a number of heart-related conditions.
High Blood Pressure. Moderate-to-severe sleep apnea definitely increases the risk for high blood pressure (hypertension) even when obesity is not a factor. Doctors are not certain whether treating OSA with CPAP reduces the risk for high blood pressure, but studies indicate that CPAP may help prevent or decrease high blood pressure.
Coronary Artery Disease and Heart Attack. Sleep apnea appears to be associated with heart disease regardless of the presence of high blood pressure or other heart risk factors. Studies suggest that patients with moderate-to-severe obstructive sleep apnea have a higher risk for heart attack.
Stroke. Sleep apnea may increase the risk of death in patients who have previously had a stroke.
Heart Failure. Up to a third of patients with heart failure also have sleep apnea. Central sleep apnea often results from heart failure. Obstructive sleep apnea can cause heart damage that worsens heart failure and increases the risk for death.
Atrial Fibrillation. Sleep apnea may be a cause of atrial fibrillation (irregular heartbeat).
Sleep apnea is associated with a higher incidence of many medical conditions, besides heart and circulation. The links between apneas and these conditions are unclear.
- Diabetes. Severe obstructive sleep apnea is associated with type 2 diabetes.
- Obesity. When it comes to sleep apnea and obesity, it is not always clear which condition is responsible for the other. For example, obesity is often a risk factor and possibly a cause of sleep apnea, but it is also likely that sleep apnea increases the risk for weight gain.
- Pulmonary hypertension (high pressure in the arteries of the lungs).
- Asthma. Sleep apnea may worsen asthma symptoms and interfere with the effectiveness of asthma medications. Treating the apnea may help asthma control.
- Seizures, epilepsy, and other nerve disorders. There may be an association between seizures and obstructive sleep apnea, especially in older adults. Some studies have shown treatment of obstructive sleep apnea may help in the control of refractory seizures.
- Headaches. Sleep disorders, including apnea, may be the underlying causes of some chronic headaches. In some patients with both chronic headaches and apnea, treating the sleep disorder may cure the headache.
- High-risk pregnancies. Sleep apnea may increase the risk of pregnancy complications, including gestational diabetes and high blood pressure.
- Eye disorders, including glaucoma, floppy eyelid syndrome, optic neuropathy conjunctivitis, dry eye, and various other infections and irritations. Some of these latter symptoms may be associated with CPAP treatments for sleep apnea.
Studies report an association between severe apnea and psychological problems. The risk for depression rises with increasing severity of sleep apnea. Sleep-related breathing disorders can also worsen nightmares and post-traumatic stress disorder.
Because sleep apnea so often includes noisy snoring, the condition can adversely affect the sleep quality of the bed partner. Spouses or partners may also suffer from sleeplessness and fatigue. In some cases, the snoring can disrupt relationships. Diagnosis and treatment of sleep apnea in the patient can help eliminate these problems.
Failure to Thrive. Small children with undiagnosed sleep apnea may "fail to thrive," that is, they do not gain weight or grow at a normal rate and they have low levels of growth hormone. In severe cases, this may affect the heart and central nervous system.
Attention Deficits and Hyperactivity. Problems in attention and hyperactivity are common in children with sleep apnea. There is some evidence that such children may be misdiagnosed with attention-deficit hyperactivity disorder. Even children who snore and do not have sleep apnea may be at higher risk for poor concentration.
People with sleep apnea usually do not remember waking during the night.
Symptoms may include:
- Excessive daytime sleepiness. Generally, patients risk falling asleep during the day while performing routine activities such as reading, watching TV, sitting inactively, lying down, or riding in a car while a passenger or stopped for a few minutes in traffic. Usually, these brief episodes of sleep do not relieve their overall sense of sleepiness.
- Morning headaches.
- Irritability and impaired mental or emotional functioning. These types of symptoms are directly related to interrupted sleep.
- Snoring. Bed partners may report very loud and interrupted snoring. Patients experience snoring associated with choking or gasps. This often occurs in a crescendo pattern with the loudest noises occurring at the very end. Snoring is more likely to occur when lying on the back. Patients often suffer from frequent arousals during sleep because of snoring.
Sleep apnea occurs in about 2% of children. They may have symptoms that differ from adults, including:
- Longer total sleep time than normal in some children, especially obese children or those with severe apnea.
- More effort in breathing (flaring nostrils, heaving chests, sweating). The chest may have an inward motion during sleep.
- Behavioral difficulties without any obvious cause, such as hyperactivity and inattention.
- Morning headaches
- Failure to grow and gain weight
The symptoms of obstructive sleep apnea are not very specific. This means that most people who snore at night or who feel tired during the day probably do not have sleep apnea. Other medical reasons for daytime sleepiness should be considered by your doctor before referral to a sleep center for diagnostic sleep tests. They include:
- Having to work excessive hours or varying shifts (nights, weekends)
- Medications (tranquilizers, sleeping pills, antihistamines beta blockers, many others)
- Alcohol abuse
- Medical conditions (such as underactive thyroid, abnormal blood sodium levels, high blood calcium levels)
- Self-imposed short sleep time
- Other sleep disorders, such as narcolepsy, insomnia, or restless legs syndrome
- Chronic fatigue syndrome
- Depression or dysthymia
Symptoms or findings that make the need for evaluation by a sleep specialist include:
- Sleepiness is affecting patient's quality of life
- Sleepiness on-the-job places the patient or others in danger
- Others have observed apnea or breath-holding episodes while asleep
- Other medical illnesses that may be worsened by obstructive sleep apnea are present.
- Children who are snoring a lot and are irritable, not thriving or growing well, or having behavioral issues
If symptoms suggest obstructive sleep apnea or other sleep disorders, further diagnostic testing will be performed. A sleep specialist or sleep disorders center will perform an in-depth medical and sleep history and physical exam. Centers should be accredited by the American Academy of Sleep Medicine.
To help determine the presence of sleep apnea, the doctor will ask the following questions:
- Are you taking any medications?
- Do you ever feel tired, feel sleepy, or lack energy during the day? If so, how often during the day? When does this usually occur?
- How restful is sleep?
- Do you frequently have morning headaches?
- Are you taking or withdrawing from stimulants, such as coffee or tobacco?
- How much alcohol do you drink each day?
- Do you have any problems with mental or emotional functioning?
- Do you suffer from heartburn?
- What is your normal sleeping position (back, side, or stomach)?
- If you have a bed partner, does he or she complain about your snoring, thrashing, or gasping for breath?
- Do you fall asleep almost as soon as your head hits the pillow? (May be a sign of sleep deprivation.)
To diagnose sleep apnea, the doctor will check for physical indications of sleep apnea, including:
- Abnormalities in the soft palate or upper airways, including enlarged tonsils
- Upper body obesity
- A wide neck measurement (over 17 inches in men or 16 inches in women)
If sleep apnea is not obvious after a physical examination and history, the doctor will need to rule out any other problems. These include sleep disorders (such as narcolepsy, insomnia, or restless legs disorder) or any medical or psychologic conditions (such as chronic fatigue syndrome or depression) that may be causing daytime sleepiness.
Sleep testing is recommended for patients who are considered at high risk for complications of obstructive sleep apnea. These include people who are obese, and those who have heart failure, coronary artery disease, or disturbances in heart rhythm.
Polysomnography is the technical term for an overnight sleep study that involves recording brain waves and other sleep-related activity. Polysomnography involves many measurements and is typically performed at a sleep center.
The patient arrives about 2 hours before bedtime without having made any changes in daily habits. Polysomnography electronically monitors the patient as he or she passes, or fails to pass, through the various sleep stages.
Overnight polysomnography has been the gold standard for diagnosing obstructive sleep apnea in both adults and children. It is very labor-intensive and expensive, however, and also misses snoring-induced arousals. After the diagnosis of sleep apnea is made, the patient must come back to the sleep center for another night in order to have CPAP started (CPAP titration).
Split-night polysomnography is an alternative option to overnight polysomnography. In split-night polysomnography, patients who have been diagnosed with obstructive sleep apnea in the first part of the evening, receive titration for CPAP during the second part of the night.
Diagnostic testing at home with portable monitors may be an option for patients who appear, based on history and physical exam, to have a high likelihood of moderate-to-severe OSA but who do not have other major medical disorders or other sleep disorders, such as narcolepsy.
Portable monitors should only be used if the patient receives a comprehensive sleep evaluation by a board-certified sleep specialist. The monitors use nasal and respiratory sensors to record airflow, respiratory effort, and blood oxygen levels. The patient needs to be educated in how to use them by an experienced sleep technician.
Patients are shown how to use these devices and then sent home. Many of these devices are also capable of titrating CPAP levels (see Treatment section).
Body position greatly affects the number and severity of episodes of obstructive sleep apnea, with at least twice as many apneas occurring in people who lay on their back as in those who sleep on their side. This may be due to the effects of gravity, which cause the throat to narrow when a person lies on the back. (Indeed, astronauts show a marked reduction in apneas and snoring in the weightlessness of space.) Positional sleep apnea affects people of all ages, including young children.
As a first step in dealing with sleep apnea, the patient should simply try rolling over onto the side. Patients who sleep on their backs and have 50 - 80 apneas per hour can sometimes nearly eliminate them when they shift to one side or the other. (Changing positions is less effective the more overweight a person is, but it still helps.)
Here are some suggestions that might help a person maintain a low-risk sleeping position:
- Sew a small pocket to the back of the pajamas and place a tennis ball or other small ball into it.
- A special pillow that helps to stretch the neck may reduce snoring and improve sleep for people with mild sleep apnea.
- Sleeping in an upright position may improve oxygen levels in overweight people with sleep apnea. Elevating the head of the bed may help.
All patients with obstructive sleep apnea who are overweight should attempt a weight-reducing program. Weight loss certainly reduces snoring and apnea/hypopnea episodes in many people, sometimes stopping it completely. It also improves sleep and significantly reduces daytime sleepiness.
- Smokers should quit, since smoking worsens apnea
- Avoid alcohol within 4 hours of sleep
- Avoid sedatives and sleeping medications
Treatment for sleep apnea depends on the severity of the problem. Given the data on the long-term complications of sleep apnea, it is important for patients to treat the problem as they would any chronic disease. Simply trying to treat snoring will not treat sleep apnea. Because of its association with heart problems and stroke, sleep apnea that does not respond to lifestyle measures should be treated by a doctor, ideally a sleep disorders specialist.
At this time, the most effective treatments for sleep apnea are devices that deliver slightly pressurized air to keep the throat open during the night. There are a number of such devices available.
The best treatment for obstructive sleep apnea is a system known as continuous positive airflow pressure (CPAP). It is safe and effective for people of all ages, including children. Patients with obstructive sleep apnea who use CPAP feel better rested, have less daytime sleepiness, and have improved concentration and memory. In addition, CPAP may potentially reduce the risks for heart problems such as high blood pressure. For maximum benefit, CPAP should be used for at least 6 - 7 hours each night.
CPAP works in the following way:
- The device itself is a machine weighing about 3 pounds that fits on a bedside table.
- A mask containing a tube connects to the device and fits over just the nose.
- The machine supplies a steady stream of air through a tube and applies sufficient air pressure to prevent the tissues from collapsing during sleep
The standard CPAP machine delivers a fixed, constant flow of air. Variations on CPAP include:
- Autotitrating positive airway pressure (APAP) devices automatically respond to changes in the sleeper’s breathing patterns by adjusting and varying the air pressure flow throughout the night. Some patients find this makes CPAP easier to tolerate.
- Bilevel positive airway pressure (BPAP) systems deliver two different pressures, a higher one for inhalation (breathing in) and a lower one for exhalation (breathing out).
CPAP works well but it can take some time to get used to, especially for the first few nights. Here are some tips to help you adjust:
- Masks are available in many different styles ranging from full face masks with adjustable straps to half masks with nasal pillows. Masks also come in different sizes. When selecting a mask, try on different styles and sizes to see which feels most comfortable.
- Make sure your doctor or CPAP service provider shows you how to adjust the mask for the best fit. A poor-fitting mask can cause skin irritation or sores. Let your doctor know if you develop any skin problems.
- When beginning CPAP treatment, it may help to wear your mask for short periods while you’re awake so you get used to how it feels. For the first few nights of treatment, begin with low air pressure and then use the ramp setting to gradually increase the pressure.
- Patients on CPAP often complain of nasal congestion and dry mouth. Many CPAP machines now come with a heated humidifier attachment. Chin straps (to keep the mouth closed) and nasal saline sprays can also help with these problems.
- To help ensure a good night’s sleep, follow sleep hygiene practices such as avoiding alcohol and caffeine before bedtime.
- Be sure to clean and maintain your equipment and mask on a daily basis. Your doctor may need to periodically readjust the air pressure settings.
In general, drugs are not very helpful except for specific situations. Medications that treat accompanying disorders associated with sleep apnea may be helpful. They include:
- Modafinil (Provigil), which is also used to treat narcolepsy, was approved by the FDA as the first drug to treat the sleepiness associated with obstructive sleep apnea. However, modanifil is meant to be used in combination with -- not as a substitute for -- standard apnea treatments such as CPAP. Sleep doctors stress that patients who take modafinil should adhere to CPAP treatment as the drug treats only the symptom of sleepiness, not the underlying obstructive sleep apnea. (Modafinil can cause rare, but serious, side effects such as life-threatening rash.)
- Thyroid hormone may help sleep apnea in those with low thyroid levels (hypothyroidism).
- Some small preliminary studies have suggested that intranasal corticosteroids may be helpful for children with obstructive sleep apnea.
Note on Sedatives. Sedatives, narcotics, antidepressants, and anti-anxiety drugs can actually worsen the breathing disturbances and arousal conditions that occur with sleep apnea. These substances cause the soft tissues in the throat to sag and diminish the body's ability to inhale. Apnea sufferers should never use sleeping pills or tranquilizers. Apnea patients undergoing surgery should be sure that their surgeons, anesthesiologists, and other doctors are aware of their sleeping disorder in considering sedatives, anesthetics, and medications taken to relieve pain due to surgery.
Oral appliances, also called dental appliances or devices, may be an option for patients who cannot tolerate CPAP. The American Academy of Sleep Medicine recommends dental devices for patients with mild-to-moderate obstructive sleep apnea who are not appropriate candidates for CPAP or who have not been helped by it. (CPAP should be used for patients with moderate-to-severe sleep apnea whenever possible.)
Several different dental devices are available. A trained dental professional such as a dentist or orthodontist should fit these devices. Devices include:
- Mandibular advancement device (MAD). This is the most widely used dental device for sleep apnea. It is similar in appearance to a sports mouth guard. MAD forces the lower jaw forward and down slightly, which keeps the airway open.
- Tongue retraining device (TRD). This is a splint that holds the tongue in place to keep the airway as open as possible.
Patients fitted with one of these devices should have a check-up early on to see if it is working; short-term success usually predicts long-term benefits. It may need to be adjusted or replaced periodically.
Benefits of Dental Devices. Dental devices seem to offer the following benefits:
- Significant reduction in apneas for those with mild-to-moderate apnea, particularly if patients sleep either on their backs or stomachs. They do not work as well if patients lie on their side. The devices may also improve airflow for some patients with severe apnea.
- Improvement in sleep in many patients
- Improvement and reduction in the frequency of snoring and loudness of snoring in most (but not all) patients
- Few or no complications
Disadvantages of Dental Devices. Dental devices are not as effective as CPAP therapy. The cost of these devices tends to be high. Side effects associated with dental devices include:
- Nighttime pain, dry lips, tooth discomfort, and excessive salivation. In general, these side effects are mild, although over the long term they cause nearly half of patients to stop using dental devices. Devices made of softer materials may produce fewer side effects.
- Permanent changes in the position of the teeth or jaw can sometimes occur with long-term use. Patients should have regular visits with a health professional to check the devices and make adjustments.
- In a small number of patients, the treatment may worsen apnea.
An orthodontic treatment called rapid maxillary expansion, in which a screw device is temporarily applied to the upper teeth and tightened regularly, may help patients with sleep apnea and a narrow upper jaw. This nonsurgical procedure helps to reduce nasal pressure and improve breathing.
Surgery is sometimes recommended, usually by ear, nose, and throat specialists, for severe obstructive sleep apnea. A patient should be sure to seek a second opinion from a specialist in sleep disorders. Few randomized clinical trials, the gold standard of medical research, have been conducted to verify the long-term efficacy of sleep apnea surgery.
The Procedure. Surgery known as uvulopalatopharyngoplasty (UPPP) removes soft tissue on the back of the throat. Such tissue includes all or part of the uvula (the soft flap of tissue that hangs down at the back of the mouth) and parts of the soft palate and the throat tissue behind it. If tonsils and adenoids are present, they are removed. The surgery typically requires a stay in the hospital.
The Goal of Surgery. The goal of UPPP is threefold:
- Increase the width of the airway at the throat's opening
- Block some of the muscle action in order to improve the ability of the airway to remain open
- Improve the movement and closure of the soft palate
Success Rates. The American Academy of Sleep Medicine does not endorse UPPP as a sole procedure for treating OSA. The AASM recommends that patients considering this surgery first try CPAP or dental devices.
There is limited evidence as to the effectiveness of UPPP. Studies suggest that success rates for sleep apnea surgery are rarely higher than 65% and often deteriorate with time, averaging about 50% or less over the long term. Few studies have been conducted on which patients make the best candidates. Some studies suggest that surgery is best suited for patients with abnormalities in the soft palate. Results are poor if the problems involve other areas or the full palate. In such cases, CPAP is superior and should always be tried first. Many or most patients with moderate or severe sleep apnea will likely still require CPAP treatment after surgery.
Complications. Uvulopalatopharyngoplasty is among the most painful treatments for sleep apnea, and recovery takes several weeks. The procedure also has a number of potentially serious complications including:
- Impaired function in the soft palate and muscles of the throat (called velopharyngeal insufficiency), which can make it difficult to keep liquids out of the airway
- Mucus in the throat
- Changes in voice frequency
- Swallowing problems
- Regurgitation of fluids through the nose or mouth
- Impaired sense of smell
- Failure and recurrence of apnea. In such cases, CPAP is often less effective afterward.
In general, only a small percentage of patients experience serious complications. Many of these complications can be avoided with proper technique and experienced surgeon. A patient's health status, including presence of obesity and other health conditions, may also affect outcomes.
A variation on UPPP called laser-assisted uvulopalatoplasty (LAUP) is being increasingly performed to reduce snoring. It removes less tissue at the back of the throat than UPPP and can be done in a doctor's office. At this time, however, long-term success rates in the treatment of obstructive sleep apnea with LAUP are very modest, particularly for reducing apneas. Some doctors, in fact, are concerned that if LAUP eliminates snoring, they may miss a diagnosis of apnea in patients who have the more serious condition.
More than half of patients complain of throat dryness after surgery. Throat narrowing and scarring have also been reported. In a minority of patients, snoring becomes worse afterward.
According to recent guidelines from the American Academy of Sleep Medicine (AASM), LAUP is not routinely recommended as treatment for obstructive sleep apnea. According to the AASM, this surgery generally does not help improve symptoms and may actually worsen the condition.
The pillar palatal implant is a noninvasive surgical treatment for mild-to-moderate sleep apnea and snoring. However, the main focus of the procedure is a reduction in snoring. The implant helps reduce the vibration and movement of the soft palate. In this procedure, a doctor inserts 3 short pieces of polyester string into the soft palate. The procedure can be performed in a doctor’s office and takes about 10 minutes. Unlike uvulopalatopharyngoplasty (UPPP), the pillar procedure requires only local anesthesia and has less pain and quicker recovery time. There is still not enough evidence to determine whether it is an effective treatment for obstructive sleep apnea.
Tracheostomy used to be the only treatment for sleep apnea. It is quite straightforward:
- The surgeon makes an opening through the neck into the windpipe and inserts a tube.
- It is almost 100% successful, but it requires a quarter-size opening in the throat. This produces a number of medical and psychological problems associated with recovery.
Today, this operation is performed rarely, usually only if sleep apnea is life threatening.
Other surgical procedures may be appropriate to correct facial abnormalities or obstructions that cause sleep apnea. They may be used alone or combined with each other or with UPPP. Most are invasive and reserved for patients with severe sleep apnea who fail to respond to or comply with CPAP. Overall, there is limited evidence as to their effectiveness in treating OSA. These procedures include:
- Radiofrequency ablation (RFA) for tongue or palate reduction.
- Maxillomandibular advancement (MMA), which moves the upper (maxilla) or lower (mandible) jawbone forward.
- Genioglossus (tongue advancement), in which an opening is cut where the tongue joins the jawbone and the area is pulled forward.
- Genioplasty, which is plastic surgery on the chin.
- Hyoid advancement surgery, in which the movable bone underneath the chin is moved forward, pulling the tongue muscle along with it.
- Surgery for nasal obstructions (such as a deviated septum) that contribute to snoring and other symptoms.
Adenotonsillectomy, or surgical removal of the tonsils and adenoids, is a first-line treatment for children and adolescents with sleep apnea proven by sleep studies. It cures or improves the condition in most patients.
Complications include respiratory illness, which occurs in about 25% of children after the surgery. The highest risk for respiratory complications is associated with:
- Age under 3 years old
- Severe sleep apnea
- Heart complications
- Failure to thrive
- Recent lung infections
- Certain facial structures
- Neuromuscular disease
The procedure may fail to improve apnea in some patients, such as those with very severe disease. Such children are candidates for continuous positive airway pressure (CPAP) therapy.
Removal of the tonsils and adenoids alone is not an effective treatment for adults with sleep apnea, although the procedure may be effective when combined with UPPP surgery.
Adult Obstructive Sleep Apnea Task Force of the American Academy of Sleep Medicine, Epstein LJ, Kristo D, Strollo PJ Jr, Friedman N, Malhotra A, et al. Clinical guideline for the evaluation, management and long-term care of obstructive sleep apnea in adults. J Clin Sleep Med. 2009 Jun 15;5(3):263-76.
Aurora RN, Casey KR, Kristo D, Auerbach S, Bista SR, Chowdhuri S, et al. Practice parameters for the surgical modifications of the upper airway for obstructive sleep apnea in adults. Sleep. 2010 Oct;33(10):1408-13.
Ballard RD. Management of patients with obstructive sleep apnea. J Fam Pract. 2008 Aug;57(8 Suppl):S24-30.
Barbé F, Durán-Cantolla J, Sánchez-de-la-Torre M, Martínez-Alonso M, Carmona C, Barceló A, et al. Effect of continuous positive airway pressure on the incidence of hypertension and cardiovascular events in nonsleepy patients with obstructive sleep apnea: a randomized controlled trial. JAMA. 2012 May 23;307(20):2161-8.
Basner RC. Continuous positive airway pressure for obstructive sleep apnea. N Engl J Med. 2007 Apr 26;356(17):1751-8.
Bradley TD, Floras JS. Obstructive sleep apnoea and its cardiovascular consequences. Lancet. 2009 Jan 3;373(9657):82-93. Epub 2008 Dec 26.
Campos-Rodriguez F, Martinez-Garcia MA, de la Cruz-Moron I, Almeida-Gonzalez C, Catalan-Serra P, Montserrat JM. Cardiovascular mortality in women with obstructive sleep apnea with or without continuous positive airway pressure treatment: a cohort study. Ann Intern Med. 2012 Jan 17;156(2):115-22.
Caples SM, Rowley JA, Prinsell JR, Pallanch JF, Elamin MB, Katz SG, et al. Surgical modifications of the upper airway for obstructive sleep apnea in adults: a systematic review and meta-analysis. Sleep. 2010 Oct;33(10):1396-407.
Chan AS, Lee RW, Cistulli PA. Dental appliance treatment for obstructive sleep apnea. Chest. 2007 Aug;132(2):693-9.
Collop NA, Anderson WM, Boehlecke B, Claman D, Goldberg R, Gottlieb DJ, et al. Clinical guidelines for the use of unattended portable monitors in the diagnosis of obstructive sleep apnea in adult patients. Portable Monitoring Task Force of the American Academy of Sleep Medicine. J Clin Sleep Med. 2007 Dec 15;3(7):737-47.
Darrow DH. Surgery for pediatric sleep apnea. Otolaryngol Clin North Am. 2007 Aug;40(4):855-75.
Esteitie R, Emani J, Sharma S, Suskind DL, Baroody FM. Effect of fluticasone furoate on interleukin 6 secretion from adenoid tissues in children with obstructive sleep apnea. Arch Otolaryngol Head Neck Surg. 2011 June;137(6):576-582.
Franklin, KA, Anttila H, Axelsson S, Gislason T, Maasilta P, Myhre K I, et al. Effects and side-effects of surgery for snoring and obstructive sleep apnea--a systematic review. Sleep. 2009 Jan 1; 32(1): 27-36.
Friedman M, Schalch P. Surgery of the palate and oropharynx. Otolaryngol Clin North Am. 2007 Aug;40(4):829-43.
Friedman M, Wilson M, Lin HC, Chang HW. Updated systematic review of tonsillectomy and adenoidectomy for treatment of pediatric obstructive sleep apnea/hypopnea syndrome. Otolaryngol Head Neck Surg. 2009 Jun;140(6):800-8.
Hirshkowitz M. The clinical consequences of obstructive sleep apnea and associated excessive sleepiness. J Fam Pract. 2008 Aug;57(8 Suppl):S9-16.
Institute for Clinical Systems Improvement (ICSI). Diagnosis and treatment of obstructive sleep apnea in adults. Bloomington (MN): Institute for Clinical Systems Improvement (ICSI); 2007 Mar.
Kasai T, Bradley TD. Obstructive sleep apnea and heart failure: pathophysiologic and therapeutic implications. J Am Coll Cardiol. 2011 Jan 11;57(2):119-27.
Kezirian EJ, Weaver EM, Yueh B, Khuri SF, Daley J, Henderson WG. Risk factors for serious complication after uvulopalatopharyngoplasty. Arch Otolaryngol Head Neck Surg. 2006 Oct;132(10):1091-8.
Marin JM, Agusti A, Villar I, Forner M, Nieto D, Carrizo SJ, et al Association between treated and untreated obstructive sleep apnea and risk of hypertension. JAMA. 2012 May 23;307(20):2169-76.
Marshall NS, Wong KK, Liu PY, Cullen SR, Knuiman MW, Grunstein RR. Sleep apnea as an independent risk factor for all-cause mortality: the Busselton Health Study. Sleep. 2008 Aug 1;31(8):1079-85.
Morgenthaler T, Alessi C, Friedman L, Owens J, Kapur V, Boehlecke B, et al. Practice parameters for the use of actigraphy in the assessment of sleep and sleep disorders: an update for 2007. Sleep. 2007 Apr 1;30(4):519-29.
Morgenthaler TI, Aurora RN, Brown T, Zak R, Alessi C, Boehlecke B, et al. Practice parameters for the use of autotitrating continuous positive airway pressure devices for titrating pressures and treating adult patients with obstructive sleep apnea syndrome: an update for 2007. An American Academy of Sleep Medicine report. Sleep. 2008 Jan 1;31(1):141-7.
Morgenthaler TI, Kapen S, Lee-Chiong T, Alessi C, Boehlecke B, Brown T, Coleman J, et al. Practice parameters for the medical therapy of obstructive sleep apnea. Sleep. 2006 Aug 1;29(8):1031-5.
Patel NP, Ahmed M, Rosen I. Split-night polysomnography. Chest. 2007 Nov;132(5):1664-71.
Patil SP, Schneider H, Schwartz AR, Smith PL. Adult obstructive sleep apnea: pathophysiology and diagnosis. Chest. 2007 Jul;132(1):325-37.
Powell S, Kubba H, O'Brien C, Tremlett M. Paediatric obstructive sleep apnoea. BMJ. 2010 Apr 14;340:c1918. doi: 10.1136/bmj.c1918.
Somers VK. Sleep apnea and cardiovascular disease. In: Bonow RO, Mann DL, Zipes DP, Libby P, eds. Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine. 9th ed. Saunders; 2011:chap 79.
Somers VK, White DP, Amin R, Abraham WT, Costa F, Culebras A, et al. Sleep apnea and cardiovascular disease: an American Heart Association/American College of Cardiology Foundation Scientific Statement from the American Heart Association Council for High Blood Pressure Research Professional Education Committee, Council on Clinical Cardiology, Stroke Council, and Council on Cardiovascular Nursing. J Am Coll Cardiol. 2008 Aug 19;52(8):686-717
Sundaram S, Bridgman SA, Lim J, Lasserson TJ. Surgery for obstructive sleep apnoea. Cochrane Database Syst Rev. 2005 Oct 19;(4):CD001004.
Young T, Finn L, Peppard PE, Szklo-Coxe M, Austin D, Nieto FJ, et al. Sleep disordered breathing and mortality: eighteen-year follow-up of the Wisconsin sleep cohort. Sleep. 2008 Aug 1;31(8):1071-8.
Harvey Simon, MD, Editor-in-Chief, Associate Professor of Medicine, Harvard Medical School; Physician, Massachusetts General Hospital. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M. Health Solutions, Ebix, Inc.
The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997-
A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.