WHAT IS THE PURPOSE OF THE STUDY?
The purpose of the study is to evaluate an investigational drug as a possible treatment for narcolepsy with or without cataplexy. An investigational drug is one that is currently being tested and is not approved by the United States Food and Drug Administration (FDA).

WHO CAN PARTICIPATE?
Individuals may be eligible to participate if they:

• Are age 18 to 70
• Have narcolepsy
• Are willing to complete a daily diary
• Are willing to provide blood samples at study visits

WILL I HAVE TO STOP MY CURRENT MEDICATIONS?
Eligible participants will have to stop any current medication taken for narcolepsy for at least 11 weeks. Other medications that should not be taken during the study and other eligibility requirements will be reviewed by the study staff.

WHAT HAPPENS DURING THE STUDY?
The study includes about 5 daytime office visits and 3 sleep-lab visits that require staying overnight and the following day. Participation lasts approximately 10-19 weeks. Screening tests are done at the first 3 visits to ensure individuals are eligible to participate.

Eligible participants will take active study drug or placebo (an inactive substance) for 8 weeks. Participants have a greater chance of taking active drug than placebo.

HOW MUCH TIME WILL THE STUDY TAKE?

Period	Visit	Type of Visit	Duration
Screening	1	Day	2-7 weeks
	2a	Night/Day
Treatment	2b	Day	8 weeks
	3	Day
	4	Night/Day
	5	Day
	6	Night/Day
Extension	7	Day	4 weeks
	8	Day
Follow-up	9	Day	4 weeks
	10	Day

WILL IT COST ME ANYTHING TO PARTICIPATE IN THE STUDY?
There are no costs to take part in the study. Participants may be compensated for time and travel

HOW DO I GET MORE INFORMATION?
Contact us at 314-205-6011 or slhsleepresearch@stlukes-stl.com.