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    Lactate dehydrogenase test

    LDH test; Lactic acid dehydrogenase test

    The lactate dehydrogenase (LDH) test measures the amount of LDH in the blood.

    See also: LDH isoenzymes

    How the Test is Performed

    A blood sample is needed. For information on how this isdone, see:Venipuncture

    How to Prepare for the Test

    Your health care provider may ask you to stop taking drugs that may affect the test. Drugs that can increase LDH measurements include anesthetics, aspirin, clofibrate, fluorides, mithramycin, narcotics, and procainamide.

    Why the Test is Performed

    LDH is most often measured to check for tissue damage. Theprotein LDH is in many body tissues, especially the heart, liver, kidney, muscles, brain, blood cells, and lungs.

    Other conditions under which the test may be done:

    • Anemia of vitamin B-12 deficiency
    • Leukemia or lymphoma
    • Megaloblastic anemia
    • Pernicious anemia

    Normal Results

    A typical range is 105 - 333 IU/L (international units per liter).

    The examples above are common measurements for results of these tests. Normal value ranges may vary slightly among different laboratories. Some labs use different measurements or test different samples. Talk to your doctor about the meaning of your specific test results.

    What Abnormal Results Mean

    Higher-than-normal levels may indicate:

    • Blood flow deficiency (ischemia)
    • Cerebrovascular accident (such as a stroke)
    • Heart attack
    • Hemolytic anemia
    • Infectious mononucleosis
    • Liver disease (for example, hepatitis)
    • Low blood pressure
    • Muscle injury
    • Muscular dystrophy
    • New abnormal tissue formation (usually cancer)
    • Pancreatitis
    • Tissue death

    If the LDH level is raised, your doctor may order an LDH isoenzymes test.

    References

    Gallagher PG. Hemolytic anemias: red cell membrane and metabolic defects In: Goldman L, Schafer AI, eds. Cecil Medicine. 24th ed. Philadelphia, Pa: Saunders Elsevier; 2011:chap 164.

    Gregg X, Prchal JT. Red Blood Cell Enzymopathies. In: Hoffman R, Benz EJ, Shattil SS, et al, eds. Hematology: Basic Principles and Practice. 5th ed. Philadelphia, Pa: Elsevier Churchill Livingstone; 2008:chap 45.

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              Tests for Lactate dehydrogenase test

              Review Date: 2/8/2012

              Reviewed By: Todd Gersten, MD, Hematology/Oncology, Palm Beach Cancer Institute, West Palm Beach, FL. Review provided by VeriMed Healthcare Network. Also reviewed by Linda J. Vorvick, MD, Medical Director and Director of Didactic Curriculum, MEDEX Northwest Division of Physician Assistant Studies, Department of Family Medicine, UW Medicine, School of Medicine, University of Washington; David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

              The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.
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              St. Luke's Hospital - 232 South Woods Mill Road - Chesterfield, MO 63017 Main Number: 314-434-1500 Emergency Dept: 314-205-6990 Patient Billing: 888-924-9200
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