CSF coccidioides complement fixation
St. Luke's Hospital
Main Number: 314-434-1500 Emergency Dept: 314-205-6990 Patient Billing: 888-924-9200
Find a Physician Payment Options Locations & Directions
Follow us on: facebook twitter Mobile Email Page Email Page Print Page Print Page Increase Font Size Decrease Font Size Font Size
America's 50 Best Hospitals
Meet the Doctor
Spirit of Women
Community Health Needs Assessment
Home > Health Information

Multimedia Encyclopedia

CSF coccidioides complement fixation

Definition

CSF coccidioides complement fixation looks for antibodies to the fungus Coccidioides immitis in the cerebrospinal (CSF) fluid, the fluid surrounding the brain and spine.

Alternative Names

Coccidioides antibody test - spinal fluid

How the Test is Performed

Complement fixation is a specific laboratory technique that looks to see if the body has produced antibodies to a specific foreign substance (antigen) -- in this case Coccidioides immitis. If the antibodies are present, they stick, or "fix" themselves, to the antigen. That's why the test is called "fixation."

The spinal fluid needed to perform this test is usually obtained by lumbar puncture (spinal tap).

How to Prepare for the Test

A consent form must be signed. You will need to remain in the hospital for about 8 hours afterwards, and you should remain lying flat.

How the Test Will Feel

See: Lumbar puncture

Why the Test is Performed

Complement fixation is the most sensitive test for the fungus Coccidioides immitis.

Normal Results

The absence of fungus (a negative test) is normal.

What Abnormal Results Mean

If the test is positive for fungus, the results indicate an active infection in the central nervous system. (See: Disseminated coccidioidomycosis ).

Risks

See: Lumbar puncture

Considerations

In some cases, this test may be done as a blood test. See also: Coccidioides complement fixation.

In the initial stage of an illness, few antibodies may be detected. Antibody production increases during the course of an infection. For this reason, such tests are often repeated several weeks after the first test is done.

Note: While an abnormal result on the spinal fluid test specifically means that the central nervous system is infected, an abnormal result on the blood test does not pinpoint the exact area of infection. It only means that there is a coccidioides infection somewhere in the body.

References

Galgiani JN. Coccidioidomycosis. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007: chap 354.


Review Date: 5/30/2009
Reviewed By: David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine; and Jatin M. Vyas, MD, PhD, Assistant Professor in Medicine, Harvard Medical School, Assistant in Medicine, Division of Infectious Disease, Department of Medicine, Massachusetts General Hospital. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.
The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.
adam.com
 


Back  |  Top
About Us
Contact Us
History
Mission
Locations & Directions
Quality Reports
Annual Reports
Honors & Awards
Community Health Needs
Assessment

Newsroom
Services
Brain & Spine
Cancer
Heart
Maternity
Orthopedics
Pulmonary
Sleep Medicine
Urgent Care
Women's Services
All Services
Patients & Visitors
Locations & Directions
Find a Physician
Tour St. Luke's
Patient & Visitor Information
Contact Us
Payment Options
Financial Assistance
Send a Card
Mammogram Appointments
Health Tools
My Personal Health
mystlukes
Spirit of Women
Health Information & Tools
Clinical Trials
Health Risk Assessments
Employer Programs -
Passport to Wellness

Classes & Events
Classes & Events
Spirit of Women
Donate & Volunteer
Giving Opportunities
Volunteer
Physicians & Employees
For Physicians
Remote Access
Medical Residency Information
Pharmacy Residency Information
Physician CPOE Training
Careers
Careers
St. Luke's Hospital - 232 South Woods Mill Road - Chesterfield, MO 63017 Main Number: 314-434-1500 Emergency Dept: 314-205-6990 Patient Billing: 888-924-9200
Copyright © St. Luke's Hospital Website Terms and Conditions  |  Privacy Policy  |  Patient Notice of Privacy Policies PDF Sitemap St. Luke's Mobile