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    Ceruloplasmin

    Ceruloplasmin is a copper-containing protein. This article discusses the test to measure the level of this protein in the clear liquid part of the blood (serum).

    How the Test is Performed

    A blood sample is needed. This may be taken from a vein. The procedure is called avenipuncture.

    How to Prepare for the Test

    No fasting or other preparation is usually needed.

    How the Test Will Feel

    When the needle is inserted to draw blood, you may feel moderate pain, or only a prick or stinging sensation. Afterward, there may be some throbbing.

    Why the Test is Performed

    Your health care provider may order this test if you have signs or symptoms of a copper metabolism or copper storage disorder.

    Normal Results

    Normal value ranges may vary slightly among different laboratories. Talk to your doctor about the meaning of your specific test results.

    What Abnormal Results Mean

    Lower-than-normal ceruloplasmin levels may be due to:

    • Chronic liver disease
    • Intestinal malabsorption
    • Malnutrition
    • Menkes' syndrome (Menkes' kinky hair syndrome) -- very rare
    • Nephrotic syndrome
    • Wilson's copper storage disease (rare)

    Higher-than-normal ceruloplasmin levels may be due to:

    • Acute and chronic infections
    • Lymphoma
    • Pregnancy
    • Rheumatoid arthritis
    • Use of birth control pills

    Risks

    Veins and arteries vary in size from one patient to another and from one side of the body to the other. Obtaining a blood sample from some people may be more difficult than from others.

    Other risks associated with having blood drawn are slight but may include:

    • Excessive bleeding
    • Fainting or feeling light-headed
    • Hematoma (blood accumulating under the skin)
    • Infection (a slight risk any time the skin is broken)

    References

    Bacon BR. Inherited and metabolic disorders of the liver. In: Goldman L, Schafer AI, eds. Cecil Medicine. 24th ed. Philadelphia, Pa: Saunders Elsevier; 2011:chap 153.

    Cox DW, Roberts EA. Wilson disease. In: Feldman M, FriedmanLS, Brandt LJ, eds. Sleisenger and Fordtran's Gastrointestinal and Liver Disease. 9th ed. Philadelphia, Pa: Saunders Elsevier; 2010:chap 75.

    Kaler SG. Wilson’s disease. In: Goldman L, Schafer AI, eds. Cecil Medicine. 24th ed. Philadelphia, Pa: Saunders Elsevier; 2011:chap 218.

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          Tests for Ceruloplasmin

          Review Date: 2/2/2013

          Reviewed By: David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine. Also reviewed by A.D.A.M. Health Solutions, Ebix, Inc., Editorial Team: David Zieve, MD, MHA, David R. Eltz, Stephanie Slon, and Nissi Wang.

          The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.
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          St. Luke's Hospital - 232 South Woods Mill Road - Chesterfield, MO 63017 Main Number: 314-434-1500 Emergency Dept: 314-205-6990 Patient Billing: 888-924-9200
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