Lupus anticoagulants
St. Luke's Hospital
Main Number: 314-434-1500 Emergency Dept: 314-205-6990 Patient Billing: 888-924-9200
Find a Physician Payment Options Locations & Directions
Follow us on: facebook twitter Mobile Email Page Email Page Print Page Print Page Increase Font Size Decrease Font Size Font Size
America's 50 Best Hospitals
Meet the Doctor
Spirit of Women
Community Health Needs Assessment
Home > Health Information

Multimedia Encyclopedia

Lupus anticoagulants

Definition

Lupus anticoagulants are antibodies against substances in the lining of cells that prevent blood clotting in a test tube. These substances are called phospholipids.

Persons with these antibodies may have an abnormally high risk of blood clotting.

See also: Antibody

Causes

Lupus anticoagulants are usually found in persons with autoimmune diseases, such as systemic lupus erythematosus (SLE).

They may also be found in persons who take certain medications, including phenothiazines, phenytoin, hydralazine, quinine, and the antibiotic amoxicillin.

Persons with inflammatory bowel disease (Crohn's disease and ulcerative colitis), infections, and certain tumors may have lupus anticoagulants.

Some people have no risk factors for this condition. In some cases, SLE is linked to an increased risk of blood clots and may be the cause of recurrent miscarriages.

Symptoms

You may not have any symptoms. Symptoms that may occur include:

  • Blood clots
  • Recurrent miscarriages

Exams and Tests

The following tests may be done:

Treatment

No treatment is required if you do not have symptoms.

If you develop blood clots, your doctor may prescribe blood thinners (heparin followed by warfarin). Higher-than-usual doses of warfarin may be needed.

Outlook (Prognosis)

The outcome is usually good with appropriate therapy. Some patients have difficult-to-control clots with recurrent symptoms.

Possible Complications

When to Contact a Medical Professional

Call your health care provider if you notice symptoms of a blood clot, which include swelling or redness in the leg, shortness of breath, or pain, numbness and pallor in an arm or leg.

Prevention

Awareness of risk factors may allow early diagnosis. Prevention may not be possible.

References

Harris ED, Budd RC, Genovese MC, Firestein GS, Sargent JS, Sledge CB. Kelley's Textbook of Rheumatology. 7th ed. St. Louis, Mo: WB Saunders; 2005.


Review Date: 1/24/2011
Reviewed By: Todd Gersten, M.D., Hematology/Oncology, Palm Beach Cancer Institute, West Palm Beach, FL. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.
The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.
adam.com
 


Back  |  Top
About Us
Contact Us
History
Mission
Locations & Directions
Quality Reports
Annual Reports
Honors & Awards
Community Health Needs
Assessment

Newsroom
Services
Brain & Spine
Cancer
Heart
Maternity
Orthopedics
Pulmonary
Sleep Medicine
Urgent Care
Women's Services
All Services
Patients & Visitors
Locations & Directions
Find a Physician
Tour St. Luke's
Patient & Visitor Information
Contact Us
Payment Options
Financial Assistance
Send a Card
Mammogram Appointments
Health Tools
My Personal Health
mystlukes
Spirit of Women
Health Information & Tools
Clinical Trials
Health Risk Assessments
Employer Programs -
Passport to Wellness

Classes & Events
Classes & Events
Spirit of Women
Donate & Volunteer
Giving Opportunities
Volunteer
Physicians & Employees
For Physicians
Remote Access
Medical Residency Information
Pharmacy Residency Information
Physician CPOE Training
Careers
Careers
St. Luke's Hospital - 232 South Woods Mill Road - Chesterfield, MO 63017 Main Number: 314-434-1500 Emergency Dept: 314-205-6990 Patient Billing: 888-924-9200
Copyright © St. Luke's Hospital Website Terms and Conditions  |  Privacy Policy  |  Patient Notice of Privacy Policies PDF Sitemap St. Luke's Mobile