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    Delta agent (Hepatitis D)

    Hepatitis D virus

    Delta agent is a type of virus called hepatitis D. Itcauses symptoms only in people who also have a hepatitis B infection.


    Hepatitis D virus (HDV) is found only in people who carry the hepatitis B virus. HDV may make a recent (acute) hepatitis B infection or an existing long-term (chronic) hepatitis B liver disease worse. It can even cause symptoms in people who carry hepatitis B virus but who never had symptoms.

    Hepatitis D infects about 15 million people worldwide. It occurs ina small numberof people who carry hepatitis B.

    Risk factors include:

    • Abusing intravenous (IV) or injection drugs
    • Being infected while pregnant (the mother can pass the virus to the baby)
    • Carrying the hepatitis B virus
    • Men having sexual intercourse with other men
    • Receiving many blood transfusions


    Hepatitis D may make the symptoms of hepatitis B worse.

    Symptoms may include:

    • Abdominal pain
    • Dark-colored urine
    • Fatigue
    • Jaundice
    • Joint pain
    • Loss of appetite
    • Nausea
    • Vomiting

    Exams and Tests

    • Anti-delta agent antibody
    • Liver biopsy
    • Liver enzymes (blood test)


    Many of the medicines used to treat hepatitis B are not helpful for treating hepatitis D. See hepatitis B.

    You may receive a medicine called alpha interferon for up to 12 months if you have along-term HDV infection. A liver transplant for end-stage chronic hepatitis B may be effective.

    Outlook (Prognosis)

    Persons with an acute HDV infection usually get better over 2 to 3 weeks. Liver enzyme levels return to normal within 16 weeks.

    About 10% of those who are infected may develop long-term (chronic) liver inflammation (hepatitis).

    Possible Complications

    • Chronic active hepatitis
    • Fulminant hepatitis

    When to Contact a Medical Professional

    Call your health care provider if you have symptoms of hepatitis B.


    Prompt diagnosis and treatment of hepatitis B infection can help prevent hepatitis D.

    Avoid intravenous drug abuse. If you use IV drugs, avoid sharing needles.

    A vaccine is available to prevent hepatitis B. Adults who are at high risk for hepatitis B infection, and all children shouldget thisvaccine.


    Perrillo R. Hepatitis B and D. In: Feldman M, Friedman LS, Brandt LJ, eds. Sleisenger and Fordtran's Gastrointestinal and Liver Disease. 9th ed. Philadelphia, Pa: Saunders Elsevier;2010:chap 78.


    • Hepatitis B virus


      • Hepatitis B virus


      A Closer Look

        Tests for Delta agent (Hepatitis D)

          Review Date: 10/8/2012

          Reviewed By: George F. Longstreth, MD, Department of Gastroenterology, Kaiser Permanente Medical Care Program, San Diego, California. Also reviewed by A.D.A.M. Health Solutions, Ebix, Inc., Editorial Team: David Zieve, MD, MHA, David R. Eltz, and Stephanie Slon.

          The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.

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          St. Luke's Hospital - 232 South Woods Mill Road - Chesterfield, MO 63017 Main Number: 314-434-1500 Emergency Dept: 314-205-6990 Patient Billing: 888-924-9200
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