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    Vasoactive intestinal peptide-producing tumor; Pancreatic endocrine tumor

    VIPoma is a very rare type of cancer that usually grows from cells in the pancreas called islet cells.


    VIPoma causes cells in the pancreas to produce a high level of a hormone called vasoactive intestinal peptide (VIP). This hormone increases secretions from the intestines. It alsorelaxes some of the smooth muscles in the GI (gastrointestinal) system.

    The cause is not known.

    VIPomas areoften diagnosed in adults, most commonly at age 50. Women are more likely to be affected than men. This cancer is rare. Only about 1 in 10 million peoplea year get it.


    • Abdominal pain and cramping
    • Diarrhea (watery, and often in large amounts)
    • Flushing or redness of the face
    • Nausea
    • Weight loss

    Exams and Tests

    Signs may include:

    • Dehydration
    • High volume of diarrhea (even without eating)
    • Low stomach acid (achlorhydria)
    • Low blood potassium (hypokalemia), which can cause leg cramps

    Tests include:

    • Blood chemistry tests (basic or comprehensive metabolic panel)
    • CT scan of the abdomen
    • MRI of the abdomen
    • Stool examination for cause of diarrhea and electrolyte levels
    • Vasoactive intestinal peptide (VIP) level in the blood


    The first goal of treatment is to correct dehydration. Fluids are often given through a vein (intravenous fluids) to replace fluids lost in diarrhea.

    The next goal is to slow the diarrhea.Medicines can help control diarrhea. One suchmedicine is octreotide. Itis a manmade form of a natural hormone blocks the action of VIP.

    The best chanceof a cure is surgery to remove the tumor. If the tumor has not spread to other organs, surgery can often cure the condition.

    Outlook (Prognosis)

    Surgery can usually cure VIPomas. But, in one third to one half of patients, the tumor has spread by the time of diagnosis and cannot be cured.

    Possible Complications

    • Cancer spread (metastasis)
    • Cardiac arrest from low blood potassium level
    • Dehydration

    When to Contact a Medical Professional

    If you have watery diarrhea for more than 2 - 3 days, call your doctor.


    Jensen RT, Norton JA. Endocrine tumors of the pancreas and gastrointestinal tract. In: Feldman M, Friedman LS, Brandt LJ, eds. Sleisenger and Fordtran's Gastrointestinal and Liver Disease. 9th ed. Philadelphia, PA: Elsevier Saunders; 2010:chap 32.

    National Cancer Institute. PDQ Pancreatic neuroendocrine tumors (islet cell tumors) treatment. Bethesda, MD: National Cancer Institute. Date last modified 11/10/2012. Available at: Accessed November 16, 2012.


    • Pancreas


      • Pancreas


      Tests for VIPoma

        Review Date: 11/17/2012

        Reviewed By: Yi-Bin Chen, MD, Leukemia/Bone Marrow Transplant Program, Massachusetts General Hospital. Also reviewed by A.D.A.M. Health Solutions, Ebix, Inc., Editorial Team: David Zieve, MD, MHA, David R. Eltz, Stephanie Slon, and Nissi Wang.

        The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.

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        St. Luke's Hospital - 232 South Woods Mill Road - Chesterfield, MO 63017 Main Number: 314-434-1500 Emergency Dept: 314-205-6990 Patient Billing: 888-924-9200
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