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Henoch-Schönlein purpura

Leukocytoclastic vasculitis; Anaphylactoid purpura; Vascular purpura

 

Henoch-Schönlein purpura is a disease that involves purple spots on the skin, joint pain, gastrointestinal problems, and glomerulonephritis (a type of kidney disorder).

Causes

 

Henoch-Schönlein is caused by an abnormal response of the immune system. The result is inflammation in the microscopic blood vessels in the skin. Blood vessels in the joints, kidneys, or the intestines may also be affected. It is unclear why this occurs.

The syndrome is mostly seen in children, but it may affect people of any age. It is more common in boys than in girls. Many people who develop this disease had an upper respiratory infection in the weeks before.

 

Symptoms

 

Symptoms may include:

  • Abdominal pain
  • Joint pain
  • Purple spots on the skin (purpura), usually over the buttocks, lower legs, and elbows
  • Bloody diarrhea
  • Hives or angioedema
  • Nausea
  • Diarrhea
  • Painful menstruation
  • Vomiting

 

Exams and Tests

 

The health care provider will look at your body and look at your skin. The physical exam will show skin sores (purpura, lesions) and joint tenderness.

Tests may include:

  • Skin biopsy
  • Urinalysis
  • Blood tests to look for other causes of blood vessel inflammation, such as systemic lupus erythematosus or hepatitis

 

Treatment

 

There is no specific treatment. Most cases go away on their own. If symptoms do not go away, you need to take corticosteroid medicine such as prednisone.

 

Outlook (Prognosis)

 

The disease most often gets better on its own.

 

Possible Complications

 

Complications may include:

  • Bleeding inside the body
  • Kidney problems (in rare cases)

 

When to Contact a Medical Professional

 

Call your provider if:

  • You develop symptoms of Henoch-Schönlein purpura, and they last for more than a few days.
  • You have low urine output after an episode of Henoch-Schönlein purpura.

 

 

References

Ardoin SP, Fels E. Vasculitis syndromes. In: Kliegman RM, Stanton B, St. Geme J, Schor N, Behrman RE, eds. Nelson Textbook of Pediatrics. 19th ed. Philadelphia, PA: Elsevier Saunders; 2011:chap 161.

Marcdante KJ, Kliegman RM. Henoch-Schöenlein purpura. In: Marcdante KJ, Kliegman RM, eds. Nelson Essentials of Pediatrics. 7th ed. Philadelphia, PA: Elsevier Saunders; 2015:chap 87.

 
  • Henoch-Schonlein purpura on the lower legs

    Henoch-Schonlein purpura on the lower legs - illustration

    Henoch-Schonlein Purpura: This disorder usually presents with red to purple bumps on the legs, often accompanied by aching in the joints and fever. This condition follows an infection and usually resolves without treatment. Skin lesions most commonly occur below the knee but may also be seen on the thigh, buttocks, and rarely on the arms.

    Henoch-Schonlein purpura on the lower legs

    illustration

  • Henoch-Schonlein purpura

    Henoch-Schonlein purpura - illustration

    Henoch-Schonlein is a type of hypersensitivity vasculitis and inflammatory response within the blood vessel. It is caused by an abnormal response of the immune system. The exact cause for this disorder is unknown.

    Henoch-Schonlein purpura

    illustration

  • Henoch-Schonlein purpura

    Henoch-Schonlein purpura - illustration

    The syndrome is usually seen in children, but people of any age may be affected. It is more common in boys than in girls. Many people with Henoch-Schonlein purpura had an upper respiratory illness in the previous weeks.

    Henoch-Schonlein purpura

    illustration

  • Henoch-Schonlein purpura

    Henoch-Schonlein purpura - illustration

    There is no specific treatment for Henoch-Schonlein purpura. Most cases resolve spontaneously without treatment. If symptoms persist, therapy with corticosteroids such as prednisone is usually tried.

    Henoch-Schonlein purpura

    illustration

  • Henoch-Schonlein purpura on an infant's foot

    Henoch-Schonlein purpura on an infant's foot - illustration

    Henoch-Schonlein purpura is more commonly seen in children than adults and often occurs after an upper respiratory infection. It causes skin rashes that bleed into the skin (petechiae and purpura). Bleeding may also occur from the gastrointestinal tract and kidneys.

    Henoch-Schonlein purpura on an infant's foot

    illustration

  • Henoch-Schonlein purpura on an infant's legs

    Henoch-Schonlein purpura on an infant's legs - illustration

    Henoch-Schonlein purpura is more commonly seen in children than adults and often occurs after an upper respiratory infection. It causes skin rashes that bleed into the skin (petechiae and purpura). Bleeding may also occur from the gastrointestinal tract and kidneys.

    Henoch-Schonlein purpura on an infant's legs

    illustration

  • Henoch-Schonlein purpura on an infant's legs

    Henoch-Schonlein purpura on an infant's legs - illustration

    Henoch-Schonlein purpura is more commonly seen in children than adults and often occurs after an upper respiratory infection. It causes skin rashes that bleed into the skin (petechiae and purpura). Bleeding may also occur from the gastrointestinal tract and kidneys.

    Henoch-Schonlein purpura on an infant's legs

    illustration

  • Henoch-Schonlein purpura on the legs

    Henoch-Schonlein purpura on the legs - illustration

    Henoch-Schonlein purpura is more commonly seen in children than adults and often occurs after an upper respiratory infection. It causes skin rashes that bleed into the skin (petechiae and purpura). Bleeding may also occur from the gastrointestinal tract and kidneys.

    Henoch-Schonlein purpura on the legs

    illustration

    • Henoch-Schonlein purpura on the lower legs

      Henoch-Schonlein purpura on the lower legs - illustration

      Henoch-Schonlein Purpura: This disorder usually presents with red to purple bumps on the legs, often accompanied by aching in the joints and fever. This condition follows an infection and usually resolves without treatment. Skin lesions most commonly occur below the knee but may also be seen on the thigh, buttocks, and rarely on the arms.

      Henoch-Schonlein purpura on the lower legs

      illustration

    • Henoch-Schonlein purpura

      Henoch-Schonlein purpura - illustration

      Henoch-Schonlein is a type of hypersensitivity vasculitis and inflammatory response within the blood vessel. It is caused by an abnormal response of the immune system. The exact cause for this disorder is unknown.

      Henoch-Schonlein purpura

      illustration

    • Henoch-Schonlein purpura

      Henoch-Schonlein purpura - illustration

      The syndrome is usually seen in children, but people of any age may be affected. It is more common in boys than in girls. Many people with Henoch-Schonlein purpura had an upper respiratory illness in the previous weeks.

      Henoch-Schonlein purpura

      illustration

    • Henoch-Schonlein purpura

      Henoch-Schonlein purpura - illustration

      There is no specific treatment for Henoch-Schonlein purpura. Most cases resolve spontaneously without treatment. If symptoms persist, therapy with corticosteroids such as prednisone is usually tried.

      Henoch-Schonlein purpura

      illustration

    • Henoch-Schonlein purpura on an infant's foot

      Henoch-Schonlein purpura on an infant's foot - illustration

      Henoch-Schonlein purpura is more commonly seen in children than adults and often occurs after an upper respiratory infection. It causes skin rashes that bleed into the skin (petechiae and purpura). Bleeding may also occur from the gastrointestinal tract and kidneys.

      Henoch-Schonlein purpura on an infant's foot

      illustration

    • Henoch-Schonlein purpura on an infant's legs

      Henoch-Schonlein purpura on an infant's legs - illustration

      Henoch-Schonlein purpura is more commonly seen in children than adults and often occurs after an upper respiratory infection. It causes skin rashes that bleed into the skin (petechiae and purpura). Bleeding may also occur from the gastrointestinal tract and kidneys.

      Henoch-Schonlein purpura on an infant's legs

      illustration

    • Henoch-Schonlein purpura on an infant's legs

      Henoch-Schonlein purpura on an infant's legs - illustration

      Henoch-Schonlein purpura is more commonly seen in children than adults and often occurs after an upper respiratory infection. It causes skin rashes that bleed into the skin (petechiae and purpura). Bleeding may also occur from the gastrointestinal tract and kidneys.

      Henoch-Schonlein purpura on an infant's legs

      illustration

    • Henoch-Schonlein purpura on the legs

      Henoch-Schonlein purpura on the legs - illustration

      Henoch-Schonlein purpura is more commonly seen in children than adults and often occurs after an upper respiratory infection. It causes skin rashes that bleed into the skin (petechiae and purpura). Bleeding may also occur from the gastrointestinal tract and kidneys.

      Henoch-Schonlein purpura on the legs

      illustration


     

    Review Date: 4/28/2015

    Reviewed By: Gordon A. Starkebaum, MD, Professor of Medicine, Division of Rheumatology, University of Washington School of Medicine, Seattle, WA. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team.

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