Hemoglobin C diseaseClinical hemoglobin C
Hemoglobin C disease is a blood disorder passed down through families. It leads to a type of anemia , which occurs when red blood cells break down earlier than normal.
Anemia is a condition in which the body does not have enough healthy red blood cells. Red blood cells provide oxygen to body tissues. Different type...
Hemoglobin C is an abnormal type of hemoglobin, the protein in red blood cells that carries oxygen. It is a type of hemoglobinopathy. The disease is caused by a problem with a gene called beta globin.
The disease most often occurs in African Americans. You are more likely to have hemoglobin C disease if someone in your family has had it.
Jaundice is a yellow color of the skin, mucus membranes, or eyes. The yellow coloring comes from bilirubin, a byproduct of old red blood cells. Jau...
Gallstones are hard deposits that form inside the gallbladder. Gallstones may be as small as a grain of sand or as large as a golf ball.
Exams and Tests
A physical exam may show an enlarged spleen .
Splenomegaly is a larger-than-normal spleen. The spleen is an organ in the upper left part of the belly.
Tests that may be done include:
In most cases, no treatment is needed. Folic acid supplements may help your body produce normal red blood cells and improve the symptoms of the anemia.
People with hemoglobin C disease can expect to lead a normal life.
Complications may include:
- Ggallbladder disease
- Enlargement of the spleen
When to Contact a Medical Professional
Call your health care provider if you have symptoms of hemoglobin C disease.
You may want to seek genetic counseling if you are at high risk for the condition and are considering having a baby.
DeBaun MR, Frei-Jones MJ, Vichinsky. Hemoglobinopathies. In: Kliegman RM, Stanton BF, St Geme JW, Schor NF, eds. Nelson Textbook of Pediatrics . 20th ed. Philadelphia, PA: Elsevier; 2016:chap 462.
Steinberg MH. Sickle cell disease and associated hemoglobinopathies. In: Goldman L, Schafer AI, eds. Goldman's Cecil Medicine . 24th ed. Philadelphia, PA: Elsevier Saunders; 2011:chap 163.
Review Date: 2/1/2016
Reviewed By: Todd Gersten, MD, Hematology/Oncology, Florida Cancer Specialists & Research Institute, Wellington, FL. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team.