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    Neurosyphilis is an infection of the brain or spinal cord. It usually occurs in persons who have had untreated syphilis for many years.


    Neurosyphilis is caused by Treponema pallidum, the bacteria that cause syphilis. It usually occurs about 10 - 20 years after a person is first infected with syphilis. Not everyone who has syphilis will develop this complication.

    There are four different forms of neurosyphilis:

    • Asymptomatic (most common form)
    • General paresis
    • Meningovascular
    • Tabes dorsalis

    Asymptomatic neurosyphilis occurs before symptomatic syphilis.


    • Abnormal walk (gait)
    • Blindness
    • Confusion
    • Dementia
    • Depression
    • Headache
    • Incontinence
    • Inability to walk
    • Irritability
    • Numbness in the toes, feet, or legs
    • Poor concentration
    • Seizures
    • Stiff neck
    • Tremors
    • Visual disturbances
    • Weakness

    Note: There may be no symptoms.

    Exams and Tests

    Signs include:

    • Abnormal reflexes
    • Muscle atrophy
    • Muscle contractions

    Blood tests can be done to detect substances produced by the bacteria that cause syphilis. The oldest test is the VDRL test.

    Other tests include:

    • Fluorescent treponemal antibody absorption (FTA-ABS)
    • Rapid plasma reagin (RPR)
    • Treponema pallidum particle agglutination assay (TPPA)

    In neurosyphilis, it is important to test the spinal fluid for signs of syphilis.

    Tests to look for problems with the nervous system may include:

    • Cerebral angiogram
    • Head CT scan
    • Lumbar puncture ("spinal tap") and a cerebrospinal fluid analysis (CSF fluid analysis)
    • MRI scan of the brain, brainstem, or spinal cord


    Penicillin is used to treat neurosyphilis. The medicine may be given in various ways.

    • It may be injected into a vein several times a day for 10 - 14 days.
    • You may take probenecid by mouth 4 times a day, combined with daily muscle injections -- both for 10 - 14 days.

    You must have follow-up blood tests at 3, 6, 12, 24, and 36 months to make sure the infection is gone. You will need follow-up lumbar punctures for CSF fluid analysis every 6 months. If you have HIV or another medical condition, your follow-up schedule may be different.

    For information on treating syphilis, see: Syphilis.

    Outlook (Prognosis)

    This is considered a life-threatening complication of syphilis. How well you do depends on how severe the neurosyphilis is before treatment.

    Possible Complications

    The symptoms can get slowly worse.

    When to Contact a Medical Professional

    Call for an appointment with your health care provider if you have had syphilis in the past and now have signs of neurological problems.


    Prompt diagnosis and treatment of the original syphilis infection can prevent neurosyphilis.


    Hook EW III. Syphilis. In: Goldman L, Schafer AI, eds. Cecil Medicine. 24th ed. Philadelphia, Pa: Saunders Elsevier; 2011: chap 327.

    Tramont EC. Treponema pallidum (syphilis). In: Mandell GL, Bennett JE, Dolin R, eds. Principles and Practice of Infectious Diseases. 7th ed. Philadelphia, Pa: Elsevier Churchill Livingstone; 2009:chap 238.


    • Central nervous system


      • Central nervous system


      Tests for Neurosyphilis

        Review Date: 10/6/2012

        Reviewed By: David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine. Jatin M. Vyas, MD, PhD, Assistant Professor in Medicine, Harvard Medical School; Assistant in Medicine, Division of Infectious Disease, Department of Medicine, Massachusetts General Hospital. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M. Health Solutions, Ebix, Inc.

        The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.

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