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Keratoconus

Vision changes - keratoconus

 

Keratoconus is an eye disease that affects the structure of the cornea. The cornea is the clear tissue that covers the front of the eye.

With this condition, the shape of the cornea slowly changes shape from round to a cone shape. It also gets thinner and the eye bulges out. This causes vision problems. In most people, these changes continue to get worse.

Causes

 

The cause is unknown. It is likely that the tendency to develop keratoconus is present from birth. The condition may be due to a defect in collagen. This is the tissue that provides the shape and strength to the cornea.

Allergy and eye rubbing may speed up the damage.

There is a link between keratoconus and Down syndrome.

 

Symptoms

 

The earliest symptom is a slight blurring of vision that cannot be corrected with glasses. (Vision can most often be corrected to 20/20 with rigid, gas-permeable contact lenses.) Over time, you may have eye halos, glare, or other night vision problems.

Most people who develop keratoconus have a history of being nearsighted. The nearsightedness tends to become worse over time. As the problem gets worse, astigmatism develops and may worsen over time.

Keratoconus is often discovered during the teenage years. It may also develop in older people.

 

Exams and Tests

 

The most accurate test for this problem is called corneal topography, which creates a map of the curve of the cornea.

A slit-lamp exam of the cornea can diagnose the disease in the later stages.

A test called pachymetry can be used to measure the thickness of the cornea.

 

Treatment

 

Contact lenses are the main treatment for most patients with keratoconus. The lenses may provide good vision, but they do not treat or stop the condition. For people with the condition, wearing sunglasses outdoors after being diagnosed may help slow or prevent the progress of the disease. For many years, the only surgical treatment has been corneal transplantation.

The following newer technologies may delay or prevent the need for corneal transplantation:

  • High-frequency radio energy (conductive keratoplasty) changes the shape of the cornea so contact lenses fit better.
  • Corneal implants (intracorneal ring segments) change the shape of the cornea so contact lenses fit better
  • Corneal collagen cross-linking is a treatment that causes the cornea to become stiff. In most cases, it prevents the condition from getting worse. It may then be possible to reshape the cornea with laser vision correction.

 

Outlook (Prognosis)

 

In most cases, vision can be corrected with rigid gas-permeable contact lenses.

If corneal transplantation is needed, results are very often good. However, the recovery period can be long. Many people still need contact lenses after the surgery.

 

Possible Complications

 

If left untreated, the cornea may thin to the point where a hole develops in the thinnest part.

There is a risk of rejection after a cornea transplant, but the risk is much lower than with other organ transplants.

You should not have laser vision correction (such as LASIK) if you have any degree of keratoconus. Corneal topography is done beforehand to rule out people with this condition.

In rare cases, other laser vision correction procedures, such as PRK, may be safe for people with mild keratoconus. This may be more possible in people who have had corneal collagen cross-linking.

 

When to Contact a Medical Professional

 

Young people whose vision cannot be corrected to 20/20 with glasses should be checked by an eye doctor familiar with keratoconus. Parents with keratoconus should consider having their children screened for the disease starting at age 10.

 

Prevention

 

There is no way to prevent this condition. Most health care providers believe that people should take steps to control allergies and avoid rubbing their eyes.

 

 

References

Jain A, Paulus YM, Cockerham GC, Kenyon KR. Keratoconus and other noninflammatory corneal thinning disorders. In: Tasman W, Jaeger EA, eds. Duane's Ophthalmology. 2013 ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2013:vol 4, chap 16C.

Kojima T, Primack JD, Azar DT. Intrastromal corneal ring segments and collagen crosslinking. In: Yanoff M, Duker JS, eds. Ophthalmology. 4th ed. Philadelphia, PA: Elsevier Saunders; 2014:chap 3.9.

Sugar J, Batta P. Keratoconus and other ectasias. In: Yanoff M, Duker JS, eds. Ophthalmology. 4th ed. Philadelphia, PA: Elsevier Saunders; 2014:chap 4.18.

 
  • Cornea

    Cornea - illustration

    The cornea is the crystal clear portion of the surface of the eye that lets light enter. The cornea is well supplied with nerve endings which is why some people can never get used to wearing contacts.

    Cornea

    illustration

    • Cornea

      Cornea - illustration

      The cornea is the crystal clear portion of the surface of the eye that lets light enter. The cornea is well supplied with nerve endings which is why some people can never get used to wearing contacts.

      Cornea

      illustration


     

    Review Date: 8/20/2016

    Reviewed By: Franklin W. Lusby, MD, ophthalmologist, Lusby Vision Institute, La Jolla, CA. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team.

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