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    Hairy leukoplakia; Smoker's keratosis

    Leukoplakia are patches on the tongue, in the mouth, or on the inside of the cheek.


    Leukoplakia affects the mucus membranes of the mouth. The exact cause is not known. Doctors think it may be due to irritation such as:

    • Rough teeth
    • Rough places on dentures, fillings, and crowns
    • Smoking or other tobacco use (smoker's keratosis), especially pipes
    • Holding chewing tobacco or snuff in the mouth for a long period of time
    • Drinking a lot of alcohol

    The disorder is most common in elderly persons.

    A type of leukoplakia of the mouth called hairy leukoplakia is caused by the Epstein-Barr virus. It is seen mostly in persons with HIV/AIDS. It may be one of the first signs of HIV infection. Hairy leukoplakia can also appear in other people whose immune system is not working well, such as after a bone marrow transplant.


    Patches in the mouth usually develop on the tongue (sides of the tongue with hairy leukoplakia)and on the insides of the cheeks.

    Leukoplakia patches appear:

    • Usually white or gray
    • Uneven in shape
    • Fuzzy (hairy leukoplakia)
    • Slightly raised with a hard surface
    • Unable to be scraped off
    • Painful when the mouth patches come into contact with acidic or spicy food

    Exams and Tests

    A biopsy of the lesion confirms the diagnosis. Examination of the biopsy may find changes that indicate oral cancer.


    The goal of treatment is to get rid of the leukoplakia patch. Removing the source of irritation may cause thepatch to disappear.

    • Treat dental causes such as rough teeth, irregular denture surface, or fillings as soon as possible.
    • Stop smoking or using other tobacco products.
    • Do not drink alcohol.

    If removing the source of the irritation does not work, the doctor may suggest applying medicine to the patch or using surgery to remove it.

    For hairy leukoplakia, taking antiviral medicine usually causes the patch to disappear. The doctor may also suggest applying medicine to the patch.

    Outlook (Prognosis)

    Leukoplakia is usually harmless.Patches inthe mouthoften clear up in a few weeks or months after the source of irritation is removed.

    Insome cases, the patches may be an early sign of cancer.

    When to Contact a Medical Professional

    Call for an appointment with your health care provider if you have anypatches that look likeleukoplakia or hairy leukoplakia.


    Stop smoking or using other tobacco products. Do not drink alcohol, or limit how many drinks you have. Have rough teeth treated and dental appliances repaired promptly.


    Allen CM, Camisa C. Oral disease. In: Bolognia JL, Jorizzo JL, Schaffer JV, eds. Dermatology. 3rd ed. Philadelphia, Pa: Elsevier Saunders; 2012:chap 72.

    Habif TP. Clinical Dermatology: A Color Guide to Diagnosis and Therapy. 5th ed. Philadelphia, Pa: Elsevier Mosby; 2009:chap 21.

    Mendoza N, Madkan V, Sra K, et al. Human herpes viruses. In: Bolognia JL, Jorizzo JL, Schaffer JV, eds. Dermatology. 3rd ed. Philadelphia, Pa: Elsevier Saunders; 2012:chap 80.


          Tests for Leukoplakia

            Review Date: 9/1/2013

            Reviewed By: Jatin M. Vyas, MD, PhD, Assistant Professor in Medicine, Harvard Medical School; Assistant in Medicine, Division of Infectious Disease, Department of Medicine, Massachusetts General Hospital. Also reviewed by David Zieve, MD, MHA, Bethanne Black, and the A.D.A.M. Editorial team.

            The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.

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            St. Luke's Hospital - 232 South Woods Mill Road - Chesterfield, MO 63017 Main Number: 314-434-1500 Emergency Dept: 314-205-6990 Patient Billing: 888-924-9200
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