Hypothalamic dysfunction is a problem with part of the brain called the hypothalamus. The hypothalamus helps control the pituitary gland and regulates many body functions.
The hypothalamus is an area of the brain that produces hormones that control:Body temperatureHungerMoodRelease of hormones from many glands, especial...
The hypothalamus helps control the pituitary gland. The pituitary is a small gland at the base of the brain. The pituitary, in turn, controls the:
The hypothalamus also helps regulate:
- Body temperature
- Production of breast milk
- Salt and water balance
- Weight and appetite
The most common causes of hypothalamic dysfunction are surgery, traumatic brain injury, tumors, and radiation.
Other causes include:
- Anorexia nervosa or bulimia
Anorexia is an eating disorder that causes people lose more weight than is considered healthy for their age and height. People with this disorder may...
- Genetic disorders that cause iron buildup in the body
- Head trauma
- Infections and swelling (inflammation)
Symptoms are usually due to the hormones that are missing. In children, there may be growth problems, either too much or too little growth. In other children, puberty occurs too early or too late.
Tumor symptoms may include headache or loss of vision.
Hypothyroidism is a condition in which the thyroid gland does not make enough thyroid hormone. This condition is often called underactive thyroid....
Fatigue is a feeling of weariness, tiredness, or lack of energy.
Obesity means having too much body fat. It is not the same as being overweight, which means weighing too much. A person may be overweight from extr...
Low adrenal function symptoms may include dizziness or weakness.
Kallmann syndrome is a genetic type of hypothalamic dysfunction. Symptoms include:
- Lowered function of sexual hormones (hypogonadism)
- Inability to smell (in some people)
Exams and Tests
The doctor will perform a physical examination and ask about your symptoms.
Blood or urine tests may be ordered to determine levels of hormones such as:
Other possible tests include:
- Hormone injections followed by timed blood samples MRI or CT scans of the brain
A magnetic resonance imaging (MRI) scan is an imaging test that uses powerful magnets and radio waves to create pictures of the body. It does not us...
- Visual field eye exam (if there is a tumor)
Treatment depends on the cause of the hypothalamic dysfunction:
- For tumors, surgery or radiation may be needed.
- For hormonal deficiencies, missing hormones need to be replaced by taking medicine.
Many causes of hypothalamic dysfunction are treatable. Most of the time, missing hormones can be replaced.
Complications of hypothalamic dysfunction depend on the cause.
- Permanent blindness
- Problems related to the brain area where the tumor occurs
- Vision disorders
- Problems controlling salt and water balance
- Heart problems
- High cholesterol
- Inability to deal with stress (such as surgery or infection), which can be life-threatening by causing low blood pressure
GROWTH HORMONE DEFICIENCY
- High cholesterol
- Short stature (in children)
When to Contact a Medical Professional
Call your doctor if you have:
- Symptoms of hormone excess or deficiency
- Vision problems
If you believe you have an eating disorder, such as anorexia or bulimia, get medical attention. These conditions can be life-threatening.
If you have symptoms of a hormonal deficiency, discuss replacement therapy with your health care provider.
Giustina A, Braunstein GD. Hypothalamic syndromes. In: Jameson JL, De Groot LJ, de Kretser DM, et al, eds. Endocrinology: Adult and Pediatric. 7th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 10.
Molitch ME. Neuroendocrinology and the neuroendocrine system. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 25th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 223.
Central nervous system - illustration
The central nervous system is comprised of the brain and spinal cord. The peripheral nervous system includes all peripheral nerves.
Central nervous system
Review Date: 10/28/2015
Reviewed By: Brent Wisse, MD, Associate Professor of Medicine, Division of Metabolism, Endocrinology & Nutrition, University of Washington School of Medicine, Seattle, WA. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team.