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    Congenital syphilis

    Congenital lues; Fetal syphilis

    Congenital syphilis is a severe, disabling, and often life-threatening infection seen in infants. A pregnant mother who has syphilis can spread the disease through the placenta to the unborn infant.


    Congenital syphilis is caused by the bacterium Treponema pallidum, which is passed from mother to child during fetal development or at birth. Nearly half of all children infected with syphilis while they are in the womb die shortly before or after birth.

    Despite the fact that this disease can be cured with antibiotics if caught early, rising rates of syphilis among pregnant women in the United States have increased the number of infants born with congenital syphilis.


    Symptoms in newborns may include:

    • Failure to gain weight or failure to thrive
    • Fever
    • Irritability
    • No bridge to nose (saddle nose)
    • Rash of the mouth, genitals, and anus
    • Rash -- starting as small blisters on the palms and soles, and later changing tocopper-colored, flat or bumpy rash on the face, palms, and soles
    • Wateryfluid releasedfrom the nose

    Symptoms in older infants and young children may include:

    • Abnormal notched and peg-shaped teeth, called Hutchinson teeth
    • Bone pain
    • Blindness
    • Clouding of the cornea
    • Decreased hearing or deafness
    • Gray, mucus-like patches on the anus and outer vagina
    • Joint swelling
    • Refusal to move a painful arm or leg
    • Saber shins (bone problem of the lower leg)
    • Scarring of the skin around the mouth, genitals, and anus

    Exams and Tests

    If the disorder is suspected at the time of birth, the placenta will be examined for signs of syphilis. A physical examination of the infant may show signs of liver and spleen swelling and bone inflammation.

    A routine blood test for syphilis is done during pregnancy. The mother may receive the following blood tests:

    • Fluorescent treponemal antibody absorbed test (FTA-ABS)
    • Rapid plasma reagin (RPR)
    • Venereal disease research laboratory test (VDRL)

    An infant or child may have the following tests:

    • Bone x-ray
    • Dark-field examination to detect syphilis bacteria under a microscope
    • Eye examination
    • Lumbar puncture


    Penicillin is used to treat all forms of syphilis.

    Outlook (Prognosis)

    Many infants who were infected early in the pregnancy are stillborn. Treatment of the expectant mother lowers the risk of congenital syphilis in the infant. Babies who become infected when passing through the birth canal have a better outlook.

    Possible Complications

    • Blindness
    • Deafness
    • Deformity of the face
    • Nervous systemproblems

    When to Contact a Medical Professional

    Call your health care provider if your baby has signs or symptoms of this condition.

    If you think that you may have syphilis and are pregnant (or anticipate becoming pregnant), call your health care provider immediately.


    Safer sexual practices may help prevent syphilis. If you suspect you have a sexually transmitted disease such as syphilis, seek medical attention immediately to avoid complications like infecting your baby during pregnancy or birth.

    Prenatal care is very important. A routine blood test for syphilis is done during pregnancy. This identifies infected mothers and allows them to be treated to reduce the risks to the infant and themselves. Infants born to infected mothers who received proper penicillin treatment during pregnancy are at minimal risk for congenital syphilis.


    Patterson MJ, Davies HD.Syphilis (Treponema pallidum). In: Kliegman RM, Behrman RE, Jenson HB, Stanton BF, eds. Nelson Textbook of Pediatrics. 19th ed. Philadelphia, Pa: Saunders Elsevier;2011:chap 210.


          A Closer Look

            Self Care

              Tests for Congenital syphilis

                Review Date: 12/1/2011

                Reviewed By: John Goldenring, MD, MPH, JD, Pediatrician with the Sharp Rees-Stealy Medical Group, San Diego, CA. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

                The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.

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