Xeroderma pigmentosum is a rare condition passed down through families in which the skin and tissue covering the eye are extremely sensitive to ultraviolet light. Some people also develop nervous system problems.
Xeroderma pigmentosum is an autosomal recessive disorder. This means you must have 2 copies of an abnormal gene in order for the disease or trait to develop. So, the disorder is inherited from both your mother and father.
Autosomal recessive disorder
Autosomal recessive is one of several ways that a trait, disorder, or disease can be passed down through families. An autosomal recessive disorder me...
Ultraviolet light, such as from sunlight, damages the genetic material (DNA) in skin cells. Normally, the body repairs this damage. But in people with xeroderma pigmentosum, the body does not fix the damage. As a result, the skin gets very thin and patches of varying color (splotchy pigmentation) appear.
Symptoms usually appear by the time a child is 2 years old.
Skin symptoms include:
- Sunburn that does not heal after just a little bit of sun exposure
- Blistering after just a little bit of sun exposure
- Spider-like blood vessels under the skin
- Patches of discolored skin that get worse
- Crusting of the skin
- Scaling of the skin
- Oozing raw skin surface
- Discomfort when being in bright light (photophobia)
- Skin cancer at a very young age (including melanoma, basal cell carcinoma, squamous cell carcinoma)
Melanoma is the most dangerous type of skin cancer. It is the leading cause of death from skin disease. Melanoma can also involve the colored part o...
Basal cell carcinoma
Basal cell cancer is the most common form of cancer in the United States. Most skin cancers are basal cell cancer. Basal cell cancer is almost alway...
Eye symptoms include:
Nervous system (neurologic) symptoms, which develop in some children, include:
Exams and Tests
The health care provider will perform a physical exam, paying special attention to the skin and eyes. The provider will also ask about a family history of xeroderma pigmentosum.
Tests that may be done include:
- Skin biopsy in which skin cells are studied in the laboratory
- DNA testing for the problem gene
The following tests can help diagnose the condition in a baby before the birth:
- Chorionic villous sampling
- Culture of amniotic cells
People with this condition need total protection from sunlight. Even the light coming through windows or from fluorescent bulbs is dangerous.
Protection from sunlight
Many skin changes, such as skin cancer, wrinkles, and age spots are caused by exposure to the sun. The two types of sun rays that can injure the skin...
When out in the sun, protective clothing must be worn.
Use sunscreen and very dark UV sunglasses. Your provider may prescribe medicine to help prevent certain precancerous growths from becoming skin cancers.
To protect the skin and eyes from the sunlight:
- Use sunscreen with an SPF 15 or higher.
- Wear long-sleeve shirts and long pants.
- Wear sunglasses that block UVA and UVB rays. Teach your child to always wear sunglasses when outdoors.
To prevent skin cancer, the provider may prescribe medicines, such as a retinoid cream, to apply to the skin.
If skin cancer develops, surgery or other methods will be done to remove the cancer.
Xeroderma Pigmentosum Society -- www.xps.org
XP Family Support Group -- www.xpfamilysupport.org
Over half of people with this condition die of skin cancer early in adulthood.
When to Contact a Medical Professional
Call for an appointment with the provider if you or your child has symptoms of xeroderma pigmentosum.
Experts recommend genetic counseling for people with a family history of xeroderma pigmentosum who wish to have children.
Lim HW, Hawk JLM. Photodermatologic disorders. In: Bolognia JL, Jorizzo JL, Schaffer JV, eds. Dermatology. 3rd ed. Philadelphia, PA: Elsevier Saunders; 2012:chap 87.
Schadt C, Fine JD. Genetic disorders predisposing to skin malignancy. In: Rigel DS, Robinson JK, Ross M, et al, eds. Cancer of the Skin. 2nd ed. Philadelphia, PA: Elsevier Saunders; 2011:chap 33.
Tamura D, Kraemer KH, DiGiovanna JJ. Xeroderma pigmentosum. In: Lebwohl MG, Heymann WR, Berth-Jones J, Coulson I, eds. Treatment of Skin Disease: Comprehensive Therapeutic Strategies. 4th ed. Philadelphia, PA: Elsevier Saunders; 2014:chap 249.
Chromosomes and DNA - illustration
Humans typically have 23 pairs chromosomes, or 46 chromosomes in total. Chromosomes are made up of long strands of DNA, which contain all the body's genes.
Chromosomes and DNA
Review Date: 4/14/2015
Reviewed By: Kevin Berman, MD, PhD, Atlanta Center for Dermatologic Disease, Atlanta, GA. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team.