Locations Main Campus: Chesterfield, MO 63017   |   Locations
314-434-1500 314-434-1500   |   Contact Us

Multimedia Encyclopedia

E-mail Form
Email Results


Hemolytic crisis

Hemolysis - acute


Hemolytic crisis occurs when large numbers of red blood cells are destroyed over a short time. The loss of red blood cells occurs much faster than the body can produce new red blood cells.



During a hemolytic crisis, the body cannot make enough red blood cells to replace those that are destroyed. This causes acute and often severe anemia .

The part of red blood cells that carries oxygen (hemoglobin) is released into the bloodstream. This can lead to kidney damage.




Causes of hemolysis include:

  • A lack of certain proteins inside red blood cells
  • Autoimmune diseases
  • Certain infections
  • Defects in the hemoglobin molecules inside red blood cells
  • Defects of the proteins that make up the internal framework of red blood cells
  • Side effects of certain medicines
  • Reactions to blood transfusions


When to Contact a Medical Professional


Call your health care provider if you have:

  • Symptoms of anemia, including pale skin or fatigue, especially if these symptoms get worse
  • Urine that is red, red-brown, or brown (tea-colored)


What to Expect at Your Office Visit


Emergency treatment may be necessary. This may include a hospital stay, oxygen, blood transfusions, and other treatments.

When your condition is stable, your provider will perform a physical examination and ask about your medical history and symptoms. The physical exam may show swelling of the spleen ( splenomegaly ).

Tests that may be done include:

  • Blood chemistry panel
  • Complete blood count ( CBC )
  • Coombs test
  • Haptoglobin
  • Hemoglobin -- blood
  • Hemoglobin -- urine
  • Kidney or abdominal CT scan
  • Kidney or abdominal ultrasound

Treatment depends on the cause of hemolysis.




Ezenkwele UA. Emergency management of red blood cell disorders. In: Adams JG, ed. Emergency Medicine: Clinical Essentials . 2nd ed. Philadelphia, PA: Elsevier Saunders; 2013:chap 204.

Gallagher PG. Hemolytic anemias: red blood cell membrane and metabolic defects. In: Goldman L, Schafer AI, eds. Goldman's Cecil Medicine . 25th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 161.


        A Closer Look


          Tests for Hemolytic crisis



            Review Date: 2/12/2016

            Reviewed By: Todd Gersten, MD, Hematology/Oncology, Florida Cancer Specialists & Research Institute, Wellington, FL. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team.

            The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.




            A.D.A.M. content is best viewed in IE9 or above, Firefox and Google Chrome browser.

            Content is best viewed in IE9 or above, Firefox and Google Chrome browser.