Rectal biopsyBiopsy - rectum; Rectal bleeding - biopsy; Rectal polyps - biopsy; Amyloidosis - rectal biopsy; Crohn disease - rectal biopsy; Colorectal cancer - biopsy; Hirschsprung disease - rectal biopsy
A rectal biopsy is a procedure to remove a small piece of tissue from the rectum for examination.
How the Test is Performed
Anoscopy is a method to look at the: AnusAnal canalLower rectum
Sigmoidoscopy is a procedure used to see inside the sigmoid colon and rectum. The sigmoid colon is the area of the large intestine nearest to the re...
A digital rectal exam is done first. Then, a lubricated instrument (anoscope or proctoscope) is placed into the rectum. You will feel some discomfort when this is done.
Digital rectal exam
A digital rectal exam is an examination of the lower rectum. The health care provider uses a gloved, lubricated finger to check for any abnormal fin...
A biopsy can be taken through any of these instruments.
A biopsy is the removal of a small piece of tissue for laboratory examination.
How to Prepare for the Test
You may get a laxative, enema, or other preparation before the biopsy so that you can completely empty your bowel. This will allow the doctor a clear view of the rectum.
How the Test will Feel
There will be some discomfort during the procedure. You may feel like you need to have a bowel movement. You may feel cramping or mild discomfort as the instrument is placed into the rectal area. You may feel a pinch when a biopsy is taken.
Why the Test is Performed
A rectal biopsy is used to determine the cause of abnormal growths found during anoscopy, sigmoidoscopy, or other tests. It can also be used to confirm the diagnosis of amyloidosis.
Primary amyloidosis is a disorder in which abnormal proteins build up in tissues and organs. Clumps of the abnormal proteins are called amyloid depo...
The anus and rectum appear normal in size, color, and shape. There should be no evidence of:
- Other abnormalities
No problems are seen when the biopsy tissue is examined under a microscope.
What Abnormal Results Mean
This test is a common way to determine the specific causes of abnormal conditions of the rectum, such as:
- Colorectal polyps
- Crohn disease
- Hirschsprung disease in infants
- Ulcerative colitis
Risks of a rectal biopsy include bleeding and tearing.
Weinstein WM. Tissue sampling, specimen handling, and chromoendoscopy. In: Ginsberg GG, Gostout CJ, Kochman ML, Norton ID, eds. Clinical Gastrointestinal Endoscopy. 2nd ed. Philadelphia, PA: Elsevier Saunders; 2012:chap 5.
Anal biopsy - illustration
Rectal biopsy can be used to determine the cause of blood, mucus, or pus in the stool. Rectal biopsy can also confirm findings of another test or x-rays, or take a biopsy of a growth found in the colon.
Review Date: 9/17/2016
Reviewed By: Debra G. Wechter, MD, FACS, general surgery practice specializing in breast cancer, Virginia Mason Medical Center, Seattle, WA. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team.