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Secretin stimulation test

Pancreatic function test

 

The secretin stimulation test measures the ability of the pancreas to respond to a hormone called secretin. The small intestine produces secretin when partially digested food from the stomach moves into the area.

How the Test is Performed

 

The doctor inserts a tube through your nose and into your stomach. The tube is then moved into the first part of the small intestine (duodenum). You are given secretin through a vein (intravenously). The fluids released from the pancreas into the duodenum are removed through the tube over the next 1 to 2 hours.

Sometimes the fluid can be collected during an endoscopy.

 

How to Prepare for the Test

 

You will be asked to not eat or drink anything, including water, for 12 hours before the test.

 

How the Test will Feel

 

You may have a gagging feeling as the tube is inserted.

 

Why the Test is Performed

 

Secretin causes the pancreas to release a fluid that contains digestive enzymes. These enzymes break down food and help the body absorb nutrients.

The secretin stimulation test is done to check the digestive function of the pancreas. The following diseases may prevent the pancreas from working properly:

  • Chronic pancreatitis
  • Cystic fibrosis
  • Pancreatic cancer

In these conditions, there may be a lack of digestive enzymes or other chemicals in the fluid that comes from the pancreas. This can reduce the body's ability to digest food and absorb nutrients.

 

Normal Results

 

Normal value ranges may vary slightly depending on the lab doing the test. Talk to your health care provider about the meaning of your specific test results.

 

What Abnormal Results Mean

 

Abnormal values may mean that the pancreas is not working properly.

 

Risks

 

There is a slight risk of the tube being placed through the windpipe and into the lungs, instead of through the esophagus and into the stomach.

 

 

References

Rao SSC. Pancreatic secretion. In: Feldman M, Friedman LS, Brandt LJ, eds. Sleisenger and Fordtran's Gastrointestinal and Liver Disease. 9th ed. Philadelphia, PA: Elsevier Saunders; 2010:chap 56.

Semrad CE. Approach to the patient with diarrhea and malabsorption. In: Goldman L, Schafer AI, eds. Goldman's Cecil Medicine. 24th ed. Philadelphia, PA: Elsevier Saunders; 2011:chap 142.

 
  • Secretin stimulation test

    Secretin stimulation test - illustration

    Secretin stimulation test is a test that measures the ability of the pancreas to respond to secretin. Secretin is a hormone secreted by the small intestines in the presence of partially digested food from the stomach; this hormone normally stimulates the pancreas to secrete a fluid with a high concentration of bicarbonate. This fluid neutralizes the acidity from the stomach that is necessary for a number of enzymes to function in the breakdown and absorption of food. In order to perform the test a tube is passed through the nose into the stomach then into the duodenum. Secretin is administered and the contents of the duodenal secretions are aspirated and analyzed over a period of about 2 hours. People with diseases involving the pancreas (for example chronic pancreatitis, cystic fibrosis, pancreatic cancer) may have abnormal pancreatic function.

    Secretin stimulation test

    illustration

    • Secretin stimulation test

      Secretin stimulation test - illustration

      Secretin stimulation test is a test that measures the ability of the pancreas to respond to secretin. Secretin is a hormone secreted by the small intestines in the presence of partially digested food from the stomach; this hormone normally stimulates the pancreas to secrete a fluid with a high concentration of bicarbonate. This fluid neutralizes the acidity from the stomach that is necessary for a number of enzymes to function in the breakdown and absorption of food. In order to perform the test a tube is passed through the nose into the stomach then into the duodenum. Secretin is administered and the contents of the duodenal secretions are aspirated and analyzed over a period of about 2 hours. People with diseases involving the pancreas (for example chronic pancreatitis, cystic fibrosis, pancreatic cancer) may have abnormal pancreatic function.

      Secretin stimulation test

      illustration

    A Closer Look

     

      Self Care

       

        Tests for Secretin stimulation test

         

         

        Review Date: 11/20/2014

        Reviewed By: Jenifer K. Lehrer, MD, Department of Gastroenterology, Frankford-Torresdale Hospital, Aria Health System, Philadelphia, PA. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team.

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