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    Drugs that may cause impotence

    Impotence caused by medications; Drug-induced erectile dysfunction; Prescription medicines and impotence


    Many different medicines and recreational drugs can have a man's sexual arousal and sexual performance. What causes impotence in one man may not affect another man.

    If you think that a medication is having a negative effect on your sexual performance,talk toyour health care provider. Never stop taking any medication without first talking to your doctor. Some medications may lead to life-threatening reactions if they are not carefully and slowly stopped orchanged.

    The following is a list of medications and nonprescription drugs that may cause impotence in men:

    Antidepressants and other psychiatric medications:

    • Amitriptyline (Elavil)
    • Amoxapine (Asendin)
    • Buspirone (Buspar)
    • Chlordiazepoxide (Librium)
    • Chlorpromazine (Thorazine)
    • Clomipramine (Anafranil)
    • Clorazepate (Tranxene)
    • Desipramine (Norpramin)
    • Diazepam (Valium)
    • Doxepin (Sinequan)
    • Fluoxetine (Prozac)
    • Fluphenazine (Prolixin)
    • Imipramine (Tofranil)
    • Isocarboxazid (Marplan)
    • Lorazepam (Ativan)
    • Meprobamate (Equanil)
    • Mesoridazine (Serentil)
    • Nortriptyline (Pamelor)
    • Oxazepam (Serax)
    • Phenelzine (Nardil)
    • Phenytoin (Dilantin)
    • Sertraline (Zoloft)
    • Thioridazine (Mellaril)
    • Thiothixene (Navane)
    • Tranylcypromine (Parnate)
    • Trifluoperazine (Stelazine)

    Antihistamine medications (certain classes of antihistamines are also used to treat heartburn):

    • Cimetidine (Tagamet)
    • Dimenhydrinate (Dramamine)
    • Diphenhydramine (Benadryl)
    • Hydroxyzine (Vistaril)
    • Meclizine (Antivert)
    • Nizatidine (Axid)
    • Promethazine (Phenergan)
    • Ranitidine (Zantac)

    High blood pressure medicines and diuretics ("water pills"):

    • Atenolol (Tenormin)
    • Bethanidine
    • Bumetanide (Bumex)
    • Captopril (Capoten)
    • Chlorothiazide (Diuril)
    • Chlorthalidone (Hygroton)
    • Clonidine (Catapres)
    • Enalapril (Vasotec)
    • Furosemide (Lasix)
    • Guanabenz (Wytensin)
    • Guanethidine (Ismelin)
    • Guanfacine (Tenex)
    • Haloperidol (Haldol)
    • Hydralazine (Apresoline)
    • Hydrochlorothiazide (Esidrix)
    • Labetalol (Normodyne)
    • Methyldopa (Aldomet)
    • Metoprolol (Lopressor)
    • Nifedipine (Adalat, Procardia)
    • Phenoxybenzamine (Dibenzyline)
    • Phentolamine (Regitine)
    • Prazosin (Minipress)
    • Propranolol (Inderal)
    • Reserpine (Serpasil)
    • Spironolactone (Aldactone)
    • Triamterene (Maxzide)
    • Verapamil (Calan)

    Among the antihypertensive medications, thiazides are the most common cause of ED, followed by beta-blockers. Alpha-blockers are, in general, less likely to cause this problem.

    Parkinson's disease medications:

    • Benztropine (Cogentin)
    • Biperiden (Akineton)
    • Bromocriptine (Parlodel)
    • Levodopa (Sinemet)
    • Procyclidine (Kemadrin)
    • Trihexyphenidyl (Artane)

    Chemotherapy and hormonal medications:

    • Antiandrogens (Casodex, Flutamide, Nilutamide)
    • Busulfan (Myleran)
    • Cyclophosphamide (Cytoxan)
    • Ketoconazole
    • LHRH agonists (Lupron, Zoladex)

    Other medications:

    • Aminocaproic acid (Amicar)
    • Atropine
    • Clofibrate (Atromid-S)
    • Cyclobenzaprine (Flexeril)
    • Cyproterone
    • Digoxin (Lanoxin)
    • Disopyramide (Norpace)
    • Estrogen
    • Finasteride (Propecia, Proscar, Avodart)
    • Furazolidone (Furoxone)
    • H2 blockers (Tagamet, Zantac, Pepcid)
    • Indomethacin (Indocin)
    • Lipid-lowering agents
    • Licorice
    • Metoclopramide (Reglan)
    • NSAIDs (Ibuprofen, etc.)
    • Orphenadrine (Norflex)
    • Prochlorperazine (Compazine)
    • Pseudoephedrine (Sudafed)

    Opiate analgesics (painkillers)

    • Codeine
    • Fentanyl (Innovar)
    • Hydromorphone (Dilaudid)
    • Meperidine (Demerol)
    • Methadone
    • Morphine
    • Oxycodone (Oxycontin, Percodan)

    Recreational drugs:

    • Alcohol
    • Amphetamines
    • Barbiturates
    • Cocaine
    • Marijuana
    • Heroin
    • Nicotine


    McVary KT. Clinical practice: Erectile dysfunction. N Engl J Med. 2007;357:2472-2481.


          A Closer Look

            Tests for Drugs that may cause impotence

              Review Date: 10/22/2012

              Reviewed By: David Zieve, MD, MHA, Medical Director, A.D.A.M. Health Solutions, Ebix, Inc., and Louis S. Liou, MD, PhD, Chief of Urology, Cambridge Health Alliance, Visiting Assistant Professor of Surgery, Harvard Medical School.

              The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.

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