Metabolic syndromeInsulin resistance syndrome; Syndrome X
Metabolic syndrome is a name for a group of risk factors that occur together and increase the chance of having coronary artery disease , stroke , and type 2 diabetes .
Coronary artery disease
Coronary heart disease is a narrowing of the small blood vessels that supply blood and oxygen to the heart. Coronary heart disease (CHD) is also cal...
A stroke occurs when blood flow to a part of the brain stops. A stroke is sometimes called a "brain attack. " If blood flow is cut off for longer th...
Type 2 diabetes
Type 2 diabetes is a lifelong (chronic) disease in which there is a high level of sugar (glucose) in the blood. Type 2 diabetes is the most common f...
Metabolic syndrome is becoming very common in the United States. Doctors are not sure whether the syndrome is due to one single cause. But many of the risks for the syndrome are related to obesity.
The two most important risk factors for metabolic syndrome are:
Extra weight around the middle and upper parts of the body (central
). This body type may be described as "apple-shaped."
Obesity means having too much body fat. It is not the same as being overweight, which means weighing too much. A person may be overweight from extr...
- Insulin resistance. Insulin is a hormone produced in the pancreas. Insulin is needed to help control the amount of sugar in the blood. Insulin resistance means that some cells in the body use insulin less effectively than normal. As a result, blood sugar level rises, which causes insulin to rise. This may increase the amount of body fat.
Other risk factors include:
- Genes that make you more likely to develop this condition
- Changes in male, female, and stress hormones
- Lack of exercise
People who have metabolic syndrome often have one or more other factors that may be linked with the condition, including:
- Increased risk for blood clotting
- Increased levels of blood substances that are a sign of inflammation throughout the body
- Small amounts of a protein called albumin in the urine
Exams and Tests
Metabolic syndrome is present if you have three or more of the following signs:
- Blood pressure equal to or higher than 130/85 mm Hg
- Fasting blood sugar (glucose) equal to or higher than 100 mg/dL
- Large waist circumference (length around the waist): For men, 40 inches (100 centimeters) or more; for women, 35 inches (90 centimeters) or more
- Low HDL (good) cholesterol: For men, less than 40 mg/dL; for women, less than 50 mg/dL
- Triglycerides equal to or higher than 150 mg/dL
The goal of treatment is to reduce your risk for heart disease, stroke, and diabetes.
Your health care provider will recommend lifestyle changes or medicines:
- Lose weight. The goal is to lose between 7% and 10% of your current weight. You will probably need to eat 500 to 1,000 fewer calories per day.
- Get 150 minutes a week of moderate intensity exercise such as walking. Do exercises to strengthen your muscles 2 days a week.
Lower your cholesterol by
eating healthier foods, losing weight, exercising
taking cholesterol-lowering medicines
, if needed.
Eating healthier foods, losing weight, ...
Hyperlipidemia - cholesterol and lifestyle; CAD - cholesterol and lifestyle; Coronary artery disease - cholesterol and lifestyle; Heart disease - cho...
Taking cholesterol-lowering medicines
Hyperlipidemia - drug treatment; Hardening of the arteries - statin
Lower your blood pressure
by eating less salt, losing weight, exercising, and taking medicine, if needed.
Lower your blood pressure
Your provider may recommend daily low-dose aspirin.
If you smoke, now is the time to quit .
The time to quit
There are many ways to quit smoking. There are also resources to help you. Family members, friends, and co-workers may be supportive. But to be su...
People with metabolic syndrome have an increased long-term risk of developing heart disease, type 2 diabetes, stroke, kidney disease, and poor blood supply to the legs.
When to Contact a Medical Professional
Call your provider if you have signs or symptoms of this condition.
Centers for Disease Control and Prevention. Physical activity basics. Updated June 4, 2015. www.cdc.gov/physicalactivity/basics . Accessed June 29, 2016.
Raynor HA, Champagne CM. Position of the Academy of Nutrition and Dietetics: interventions for the treatment of overweight and obesity in adults. J Acad Nutr Diet . 2016;116(1):129-147. PMID: 26718656. www.ncbi.nlm.nih.gov/pubmed/26718656 .
Ruderman NB, Shulman GI. Metabolic syndrome. In: Jameson JL, De Groot LJ, de Kretser DM, et al, eds. Endocrinology: Adult and Pediatric . 7th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 43.
Review Date: 5/17/2016
Reviewed By: Laura J. Martin, MD, MPH, ABIM Board Certified in Internal Medicine and Hospice and Palliative Medicine, Atlanta, GA. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team.