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    Stereotactic radiosurgery - Gamma Knife

    Stereotactic radiotherapy; stereotactic radiosurgery;SRT; Fractionated stereotactic radiotherapy; SRS

    Stereotactic radiosurgery (SRS) is a form of radiation therapy that focuses high-power energy on a small area of the body.

    Despite its name, radiosurgery is a treatment, not a surgical procedure. Incisions (cuts) are not made on your body.

    More than one system is used to perform radiosurgery. This article is about Gamma Knife radiosurgery.


    Gamma Knife radiosurgery is done only for tumors and other medical problems of the head. For tumors and problems elsewhere in the body, other radiosurgery systems may be used.

    Before treatment, you are fitted with a head frame. The frame is attached to your scalp. This is done using 4 small pins or anchors that go through your skin to the surface of your skull. Medicine is first given to numb the areas where the pins or anchors attach.

    The frame keeps your head steady during treatment. It also helps your doctors ensure the energy beams are aimed at the exact spot in your head that needs treatment.

    After the frame is attached to your head, imaging tests such as CT, MRI, or angiogram are done. The images show the exact location, size, and shape of your tumor or problem area.

    During treatment:

    • You lie on a table that slides into a machine that delivers radiation.
    • The head frame is attached to a helmet that has many holes. The energy beams are delivered through these holes.
    • The machine may move your head so that theenergy beams are delivered to the exact spots that need treatment.
    • The nurses and doctors will be able to see you on cameras. Theycan hear you and talk with you on microphones.
    • You will not need to be put to sleep and the treatment does not cause pain.

    Each treatment takes a few minutes to 2 hours. You may receive more than one treatment session. Most often, no more than five sessions are needed.

    Why the Procedure is Performed

    SRStargets and treats an abnormal area without damaging nearby healthy tissue.

    Gamma Knife radiosurgery is used to treat the following types of brain tumors:

    • Cancer that has spread (metastasized)to the brain from another part of the body
    • A slow-growing tumor of the nerve that connects the ear to the brain (acoustic neuroma)
    • Pituitary tumors
    • Tumors that are not cancer (chordoma, meningioma)

    Gamma Knife is also used to treat other problems of the brain:

    • Blood vessel problems (arteriovenous malformation, arteriovenous fistula)
    • Some types of epilepsy
    • Trigeminal neuralgia (severe nerve pain of the face)
    • Severe tremors due to essential tremor or Parkinson disease


    Radiosurgery may damage tissue around the area being treated. As compared to other types of radiation therapy, Gamma Knife treatment is much less likely to damage nearby healthy tissue.

    Brain swelling may occur. Swelling usually goes away without treatment. Some people need medicine to control this swelling.In rare cases, surgery with incisions (open surgery) is needed to treat the brain swelling caused by the radiation.

    The spots where the head frame is attached to your scalp may be red and sensitive after treatment. This should go away with time.

    Outlook (Prognosis)

    Often, you will be able to go home about 1 hour after the treatment. Arrange ahead of time for someone to drive you home. You can go back to your regular activities the next day if there are no complications such as swelling. If you have complications, you may need to stay in the hospital overnight for monitoring.

    The effects of Gamma Knife radiosurgery may take weeks or months to be seen. The prognosis depends on the condition being treated. Your health care provider will monitor your progress using imaging tests such as MRI and CT scans.

    The day before your procedure:

    • Do not use any hair cream or hair spray.
    • Do not eat or drink anything after midnight unless told otherwise by your doctor.

    The day of your procedure:

    • Wear comfortable clothing.
    • Bring your regular prescription medicines with you to the hospital.
    • Do not wear jewelry, makup, nail polish, or a wig or hairpiece.
    • You will be asked to remove contact lenses, eyeglasses, and dentures.
    • You will change into a hospital gown.
    • An intravenous (IV) line will be placed into your arm to deliver contrast material, medicines, and fluids.


    Chang EF, Quigg M, Oh MC, et al. Epilepsy Radiosurgery Study Group. Predictors of efficacy after stereotactic radiosurgery for medial temporal lobe epilepsy. Neurology. 2010;74:165-172.

    Ewend MG, Morris DE, Carey LA, et al. Guidelines for the initial management of metastatic brain tumors: role of surgery, radiosurgery, and radiation therapy. J Natl Compr Canc Netw. 2008;6:505-513.

    Suh JH. Stereotactic radiosurgery for the management of brain metastases. N Engl J Med. 2010;362:1119-1127.

    Welling DB, Packer MD. Stereotactic radiation treatment of benign tumors of the cranial basae. In: Flint PW, Haughey BH, Lund VJ, et al., eds. Cummings Otolaryngology: Head & Neck Surgery. 5th ed. Philadelphia, PA: Elsevier Mosby; 2010:chap 179.


          A Closer Look

          Tests for Stereotactic radiosurgery - Gamma Knife

            Review Date: 3/8/2013

            Reviewed By: Luc Jasmin, MD, PhD, Department of Neurosurgery, Cedars Sinai Medical Center, Los Angeles and Department of Anatomy, University of California, San Francisco, CA. Review provided by VeriMed Healthcare Network. Also reviewed by A.D.A.M. Health Solutions, Ebix, Inc., Editorial Team: David Zieve, MD, MHA, Bethanne Black, Stephanie Slon, and Nissi Wang.

            The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.

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