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How to take statins

Antilipemic Agent; HMG-CoA reductase inhibitors; Atorvastatin (Lipitor®); Simvastatin (Zocor®); Lovastatin (Mevacor®, Altoprev®); Pravastatin (Pravachol®); Rosuvastatin (Crestor®); Fluvastatin (Lescol®); Hyperlipidemia - statins; Hardening of the arteries statins; Cholesterol - statins; Hypercholesterolemia - statins; Dyslipidemia -statins; Statin

 

Statins are medicines that help lower the amount of cholesterol and other fats in your blood. Statins work by:

  • Lowering LDL (bad) cholesterol
  • Raising HDL (good) cholesterol in your blood
  • Lowering triglycerides , another type of fat in your blood

Statins block how your liver makes cholesterol. Cholesterol can stick to the walls of your arteries and narrow or block them.

How do Statins Help?

 

Improving your cholesterol levels can help protect you from heart disease, heart attack, and stroke.

Your health care provider will work with you to lower your cholesterol by improving your diet. If this is not successful, medicines to lower cholesterol may be the next step.

Statins are often the first drug treatment for high cholesterol. Both adults and teenagers can take statins when needed.

 

What Statins are Right for you?

 

There are different brands of statin drugs, including less expensive, generic forms. For most people, any of the statin drugs will work to lower cholesterol levels. However, some people may need the more powerful types.

A statin may be prescribed along with other medicines. Combination tablets are also available. They include a statin plus medicine to manage another condition, such as high blood pressure.

 

How are Statins Taken?

 

Take your medicine as directed. The medicine comes in tablet or capsule form. DO NOT open capsules, or break or chew tablets, before taking the medicine.

You take statins once a day. Some should be taken at night, but others can be taken anytime. They come in different doses, depending on how much you need to lower your cholesterol. DO NOT stop taking your medicine without talking with your doctor or nurse first.

Read the label on the bottle carefully. Some brands should be taken with food. Others may be taken with, or without food.

Store all of your medicines in a cool, dry place. Keep them where children cannot get to them.

You should follow a healthy diet while taking statins. This includes eating less fat in your diet . Other ways you can help your heart include:

  • Getting regular exercise
  • Managing stress
  • Quitting smoking

 

What are the Risks?

 

Before you start taking statins, tell your provider if:

  • You are pregnant, plan to become pregnant, or are breastfeeding. Pregnant and nursing mothers should not take statins.
  • You have allergies.
  • You are taking other medicines.
  • You have diabetes.
  • You have liver disease. You should not take statins if you have acute or chronic liver diseases.

Tell your provider about all of your medications, supplements, vitamins, and herbs. Certain medicines may interact with statins. Be sure to tell your provider before taking any new medicines.

Overall, there is no need to avoid moderate amounts of grapefruit in the diet. An 8 ounce (240 mL) glass or one grapefruit can be safely consumed.

Regular blood tests will help you and your provider:

  • See how well the medicine is working
  • Monitor for side effects, such as liver problems

 

Possible Side Effects

 

Mild side effects may include:

  • Muscle/joint aches
  • Diarrhea
  • Nausea
  • Constipation
  • Dizziness
  • Headache
  • Upset stomach
  • Gas

Though rare, more serious side effects are possible. Your provider will monitor you for signs. Talk with your provider about the possible risks for:

  • Liver damage
  • Severe muscle problems
  • Kidney damage
  • High blood sugar, or type 2 diabetes
  • Memory loss
  • Confusion

 

When to Call the Doctor

 

Tell your health care provider right away if you have:

  • Muscle or joint pain or tenderness
  • Weakness
  • Fever
  • Dark urine
  • Other new symptoms

 

 

References

American Heart Association. Drug Therapy for Cholesterol. Available at: www.heart.org/HEARTORG/Conditions/Cholesterol/PreventionTreatmentofHighCholesterol/Drug-Therapy-for-Cholesterol_UCM_305632_Article.jsp . Last reviewed March 21, 2014. Accessed March 22, 2016 .

Genest J, Libby P. Lipoprotein disorders and cardiovascular disease. In: Mann DL, Zipes DP, Libby P, Bonow RO, Braunwald E, eds. Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine . 10th ed. Philadelphia, PA: Elsevier Saunders; 2015:chap 45.

Gudzune KA, Monroe AK, Sharma R, Ranasinghe PD, Chelladurai Y, Robinson KA. Effectiveness of combination therapy with statin and another lipid-modifying agent compared with intensified statin monotherapy: a systematic review. Annals of Internal Medicine . 2014:160(7);468-476. PMID: 24514899 www.ncbi.nlm.nih.gov/pubmed/24514899 .

Lee JW, Morris JK, Wald NJ. Grapefruit Juice and Statins. Am J Med . 2016;129(1):26-29. PMID: 26299317 www.ncbi.nlm.nih.gov/pubmed/26299317 .

Semenkovich CF Disorders of lipid metabolism. In: Goldman L, Schafer AI, eds. Goldman's Cecil Medicine . 25th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 206.

Stone NJ, Robinson J, Lichtenstein AH, Bairey Merz CN, Blum CB, Eckel RH, Goldberg AC, Gordon D, Levy D, Lloyd-Jones DM, McBride P, Schwartz JS, Shero ST, Smith SC Jr, Watson K, Wilson PWF. 2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation . 2014;1239(25 Suppl 2): S46-S48. PMID: 24222016 www.ncbi.nlm.nih.gov/pubmed/24222016 .

 

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              Review Date: 2/24/2016

              Reviewed By: Michael A. Chen, MD, PhD, Associate Professor of Medicine, Division of Cardiology, Harborview Medical Center, University of Washington Medical School, Seattle, WA. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team.

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